We are analyzing https://link.springer.com/article/10.1186/s12916-015-0278-7.

Title:
New horizons in tumor microenvironment biology: challenges and opportunities | BMC Medicine
Description:
The tumor microenvironment (TME) is being increasingly recognized as a key factor in multiple stages of disease progression, particularly local resistance, immune-escaping, and distant metastasis, thereby substantially impacting the future development of frontline interventions in clinical oncology. An appropriate understanding of the TME promotes evaluation and selection of candidate agents to control malignancies at both the primary sites as well as the metastatic settings. This review presents a timely outline of research advances in TME biology and highlights the prospect of targeting the TME as a critical strategy to overcome acquired resistance, prevent metastasis, and improve therapeutic efficacy. As benign cells in TME niches actively modulate response of cancer cells to a broad range of standard chemotherapies and targeted agents, cancer-oriented therapeutics should be combined with TME-targeting treatments to achieve optimal clinical outcomes. Overall, a body of updated information is delivered to summarize recently emerging and rapidly progressing aspects of TME studies, and to provide a significant guideline for prospective development of personalized medicine, with the long term aim of providing a cure for cancer patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

cancer, pubmed, cells, article, google, scholar, cas, cell, tumor, tme, central, resistance, mscs, therapeutic, stromal, microenvironment, stem, mesenchymal, including, clinical, growth, metastasis, signaling, factor, immune, tumors, therapy, stroma, factors, progression, agents, nat, breast, bone, metastatic, disease, promotes, treatment, sun, res, multiple, targeting, response, studies, mechanisms, niche, fibroblasts, anticancer, endothelial, therapies,

Topics {✒️}

view promote tgf-beta/smad signaling author information authors dendritic cell-derived hb-egf future clinical intervention tumour micro-environment heterogeneity bone marrow-derived gr1 myeloid-derived suppressor cell mtorc1/c-myc pathway bone marrow-derived cell author correspondence ying wang tgf-β/smad signaling [47-51] wnt/beta-catenin axes bone marrow-derived cells c-myc inactivation induces bone marrow-derived mscs arf-null lymphoblastic leukemia p53-deficient mscs resulted cytokine/chemokine-mediated pathways typically therapy-resistant due hypoxia-inducible factor 1α receptor/beta-arrestin signaling patient-derived xenograft reflects treatment-resistant cancers harbor combination treatment treatment strategy p53-deficient mice express cd4+ t-lymphocyte instigation combination therapies platinum-induced fatty acids article download pdf tumour growth supports tumor type-specific tmes growth-factor-driven resistance tumour-stromal interactions inducing carboplatin-specific resistance established eμ-myc model critical strategy intra-tumour heterogeneity pro-metastatic activities mediated anti-pd-l1 immunotherapy metastasis-incompetent cancer cells shanghai rising-star program open access license immunomodulation mediated paracrine tumor-stroma interaction dna damage-mediated induction hgf/met-driven resistance clinical oncology

Questions {❓}

Intra-tumour heterogeneity: a looking glass for cancer?
Tackling the tumor microenvironment: what challenge does it pose to anticancer therapies?
Why don’t we get more cancer?

Schema {🗺️}

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      headline:New horizons in tumor microenvironment biology: challenges and opportunities
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      name:Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiaotong University School of Medicine, Shanghai, China
      name:Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiaotong University School of Medicine, Shanghai, China
      name:Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiaotong University School of Medicine, Shanghai, China
      name:Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiaotong University School of Medicine, Shanghai, China
      name:Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiaotong University School of Medicine, Shanghai, China
      name:Soochow Institutes for Translational Medicine, Soochow University, Suzhou, China
      name:Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiaotong University School of Medicine, Shanghai, China
      name:Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiaotong University School of Medicine, Shanghai, China
      name:VA Seattle Medical Center, Seattle, USA
      name:Department of Medicine, University of Washington, Seattle, USA
      name:Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Shanghai Jiaotong University School of Medicine (SJTUSM), Shanghai, China

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