
NCBI . NLM . NIH . GOV {
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Title[redir]:
Pan-tumor genomic biomarkers for PD-1 checkpoint blockadeābased immunotherapy - PMC
Description:
Immunotherapy targeting the programmed cell death proteinā1 (PD-1) axis elicits durable antitumor responses in multiple cancer types. However, clinical responses vary, and biomarkers predictive of response may help to identify patients who will ...
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Keywords {š}
tmb, doi, gep, response, cellinflamed, patients, cancer, google, scholar, tumor, tumors, pmid, pubmed, pmc, expression, cohorts, clinical, cohort, article, free, melanoma, gene, fig, data, pdl, pantumor, hnscc, cell, genes, pembrolizumab, tmbhi, mutations, analysis, biomarkers, versus, low, association, keynote, types, somatic, correlation, blockade, predictive, samples, signatures, defined, high, tmblo, set, observed,
Topics {āļø}
org/content/362/6411/eaar3593/suppl/dc1 references pd-l1 ihcābased assay t-cell-dependent mechanism tumor cellāintrinsic pathways ifn-gamma-induced upregulation transcript-specific ternary complexes cellāinflamed gepādefined groups pmc beta search triple-negative breast cancer allele-specific copy number single-indication summary cohorts progression-free survival nanostring clinical-grade assay individual biomarker-based groups antiāpd-1ādirected therapy pd-l1āunselected b2 cellāderived ifn-γ single-indication clinical cohorts pd-l1 gene expression pd-l2 gene expression tumor typeāspecific dysregulation small-cell lung cancer programmed death ligand-1 cellāderived interferon-γ cellāinflamed tumor microenvironment 5-μm-thick ffpe sections interferon regulatory factor-1 emerging tumor-agnostic biomarkers mutect-called somatic snvs cohort-specific cut points hnscc single-indication cohort gov/docs/publications/tcga/ pd-l1-unselected hnscc tmb biomarkerābased stratification cellāinflamed gep signature mutect-called snvs present keynote-012 pd-l1āpositive cellāinflamed gep scores cellāinflamed gep signatures pd-l1āpositive cells cellāinflamed gep score patientādefined biomarker groups greater pd-l1 expression cellāinflamed cytolytic processes biomarker-defined response groups [google scholar] 22 determine pd-l1 positivity top pan-cancer tertile pd-l1āpositive head patient-level clinical data
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