
NCBI . NLM . NIH . GOV {
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Title[redir]:
Proteome Analysis Identified the PPARγ Ligand 15d-PGJ2 as a Novel Drug Inhibiting Melanoma Progression and Interfering with Tumor-Stroma Interaction - PMC
Description:
Peroxisome proliferator-activated receptors (PPARs) have been originally thought to be restricted to lipid metabolism or glucose homeostasis. Recently, evidence is growing that PPARγ ligands have inhibitory effects on tumor growth. To shed light on ...
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Keywords {🔍}
dpgj, cells, melanoma, cell, pubmed, google, scholar, doi, tumor, proteins, protein, fibroblasts, pparγ, data, analysis, cancer, endothelial, hsp, table, ligands, effects, proliferation, fig, hours, pmc, peroxisome, treatment, receptor, expression, growth, mmet, pdf, lines, human, database, identified, article, proliferatoractivated, formation, stroma, huvecs, treated, tube, migration, uniprot, free, agonists, addition, electrophoresis, concentrations,
Topics {✒️}
peroxisome proliferator-activated receptor-γ modulate wnt/beta-catenin signalling peroxisome proliferator-activated receptor peroxisome proliferator-activated receptors peroxisome proliferator-activating receptors 15d-pgj2-treated a375 compared anti-human cd34 antibody low-affinity endogenous ligand anti-rabbit igg hrp ligand-activated transcription factors ms/ms fragmentation analysis exerts anti-lymphangiogenic activity lub-de hooge mn indicating 15d-pgj2-induced phosphorylation i-kappa-b-kinase 2 remaining cd34-negative cells pmc beta search clusterin regulates drug-resistance computer-assisted analyses system cpl/muw proteome database 15d-pgj2 highly downregulates g1 cyclin-dependent kinases 15d-pgj2 treated samples lipid-activated nuclear receptors stage-dependent prognostic markers isopropanol-acetic acid solution sensitive upon15d-pgj2 treatment pparγ-positive metastases showed cell type-specific proteins vegf-induced angiogenic activities single compound 15d-pgj2 15d-pgj2 exhibits effects potent anti-tumorigenic compound protein count/peptide count = 7/7 15d-pgj2 specifically interferes 15d-pgj2 inhibited proliferation anti-cancer therapies targeting shot gun analysis pparγ ligand 15d-pgj2 �activated” stroma phenotype poor disease-free license information pmcid 15d-pgj2 induced phosphorylation regulate diverse cellular supplementary materials included casein kinase ii biomodulatory stroma-targeted therapy cell cycle analysis written informed consent anti-mouse igg
Questions {❓}
- Schadendorf D (2009) Peroxisome proliferator-activating receptors: a new way to treat melanoma?
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