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We are analyzing https://www.nature.com/articles/s41392-022-01110-y.

Title:
Regulated cell death (RCD) in cancer: key pathways and targeted therapies | Signal Transduction and Targeted Therapy
Description:
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the form of cell death that can be regulated by a variety of biomacromolecules, which is distinctive from accidental cell death (ACD). Accumulating evidence has revealed that RCD subroutines are the key features of tumorigenesis, which may ultimately lead to the establishment of different potential therapeutic strategies. Hitherto, targeting the subroutines of RCD with pharmacological small-molecule compounds has been emerging as a promising therapeutic avenue, which has rapidly progressed in many types of human cancers. Thus, in this review, we focus on summarizing not only the key apoptotic and autophagy-dependent cell death signaling pathways, but the crucial pathways of other RCD subroutines, including necroptosis, pyroptosis, ferroptosis, parthanatos, entosis, NETosis and lysosome-dependent cell death (LCD) in cancer. Moreover, we further discuss the current situation of several small-molecule compounds targeting the different RCD subroutines to improve cancer treatment, such as single-target, dual or multiple-target small-molecule compounds, drug combinations, and some new emerging therapeutic strategies that would together shed new light on future directions to attack cancer cell vulnerabilities with small-molecule drugs targeting RCD for therapeutic purposes.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Science
  • Health & Fitness
  • Education

Content Management System {📝}

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Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,554,915 visitors per month in the current month.

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Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

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Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$536,300 per month
Our analysis indicates Nature.com generates between $357,503 and $983,134 monthly online from display ads.

Keywords {🔍}

pubmed, cancer, cell, cells, google, scholar, article, cas, apoptosis, death, central, tumor, autophagy, pathway, targeting, expression, induce, ferroptosis, inhibitor, treatment, protein, pathways, pyroptosis, induces, signaling, necroptosis, inhibit, activity, breast, therapy, growth, activation, resistance, tumors, drug, human, ripk, inhibition, effect, target, proliferation, antitumor, membrane, complex, sci, proteins, parp, mol, caspase, shown,

Topics {✒️}

nature portfolio 5-dimethyl-4-sulfonyl-1h-pyrrole-based compound 40 privacy policy anti-trop-2-sn-38 antibody-drug conjugate methotrexate-loaded tumour-cell-derived microvesicles ros/nlrp3/caspase-1/gsdmd-mediated pyroptotic pathway 5-bromo-4-phenoxy-n-phenylpyrimidin-2-amine derivatives eef2k-ampk-mtor-ulk complex axis targeting pi3k/akt/mtor-mediated autophagy advertising quercetin 3-o-β-d-galactopyranoside wnt/β-catenin signaling pathway nf-κb/ampk/mtor/ulk1 axis wnt/β-catenin signaling pathways β-catenin/wnt-signaling pathways jnk/p300/p50 signaling pathway cascaded copper-based nanocatalyst ras/raf/mek/erk axis oncogenic-ras-harboring cancer cells buffer solutions suppressing wnt/β-catenin signaling ras/raf/mek/erk pathway pi3k/akt/mtor signaling pathway social media mutant c-k-ras genes pi3k/akt/mtor signaling inhibitor ampk-foxo1-ulk1-snail axis multiple-target small-molecule compounds b-cell lymphoma-extra large pi3k/akt/mtor signal pathway synthetic β-nitrostyrene derivative α-kg derivative dmα-kg c-jun n-terminal kinase caspase-mediated p65/rela cleavage cdc42/rhoa/rock/myosin signaling pathways reprints mtor-ampk-ulk1 signaling pathway inhibiting pi3k/akt/mtor pathway ros-mediated mek/erk pathway wnt/β-catenin pathway289 crispr/cas9 screening identifies targeting ampk-ulk1-mediated autophagy rapamycin pi3k/akt/mtor pathway tlr4/trif/irf3 signaling pathway numerous small-molecule compounds ros/jnk/p53-dependent pathway p62-keap1-nrf2 pathway protects wnt/β-catenin pathway ras/raf/mapks pathway small-molecule compounds targeting

Questions {❓}

  • Apoptosis and cancer: force awakens, phantom menace, or both?
  • Editorial: adverse effects of cancer chemotherapy: anything new to improve tolerance and reduce sequelae?
  • How do glycolytic enzymes favour cancer cell proliferation by nonmetabolic functions?
  • How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
  • Killing a cancer: what are the alternatives?
  • Lighting a fire: can we harness pyroptosis to ignite antitumor immunity?

Schema {🗺️}

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PostalAddress:
      name:West China School of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
      name:West China School of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
      name:State Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
      name:West China School of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
      name:Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China
      name:State Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
      name:Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China
      name:West China School of Pharmacy, State Key Laboratory of Biotherapy and Cancer Center, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China
      name:State Key Laboratory of Southwestern Chinese Medicine Resources, Hospital of Chengdu University of Traditional Chinese Medicine, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China

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