LINK . SPRINGER . COM {}

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Pivotx (1 occurrences)

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We are analyzing https://link.springer.com/article/10.1186/s13045-020-00949-4.

Title:
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy | Journal of Hematology & Oncology
Description:
Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40% human cancer cases. To drive carcinogenesis, this signaling promotes cellular overgrowth by turning on proliferative genes, and simultaneously enables cells to overcome metabolic stress by inhibiting AMPK signaling, a key singular node of cellular metabolism. Recent studies have shown that AMPK signaling can also reversibly regulate hyperactive MAPK signaling in cancer cells by phosphorylating its key components, RAF/KSR family kinases, which affects not only carcinogenesis but also the outcomes of targeted cancer therapies against the MAPK signaling. In this review, we will summarize the current proceedings of how MAPK-AMPK signalings interplay with each other in cancer biology, as well as its implications in clinic cancer treatment with MAPK inhibition and AMPK modulators, and discuss the exploitation of combinatory therapies targeting both MAPK and AMPK as a novel therapeutic intervention.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Education
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Link.springer.com is based on PIVOTX.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

The income method remains a mystery to us.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

pubmed, google, scholar, cas, ampk, cancer, kinase, central, signaling, cell, protein, raf, mapk, cancers, ras, cells, inhibitors, braf, biol, autophagy, activity, kinases, activation, mek, cellular, stress, inhibition, pathway, melanoma, fig, erk, phosphorylation, mol, role, ampactivated, mutations, clinical, resistance, chem, growth, energy, proteins, nat, metabolic, craf, active, oncogenic, inhibitor, nature, sci,

Topics {✒️}

blocking hyperactive ras/raf/mek/erk view mitogen-activated protein/erk kinase ras-independent braf-mutant-driven signaling akt-mdm2-foxo3a signaling axis raf/mek/erk kinase cascade clinical profiles hyperactive ras/raf/mek/erk organism/tissue/stage-specific selectivity raf/mek/erk signaling pathway targeting erk-hippo interplay treat ras/raf-mutated cancers author information authors murine protein-tyrosine/threonine kinase k-ras-induced lung tumors anti-ras/raf cancer therapy generation raf/mek/erk inhibitors treating ras/raf-mutated cancers treat ras/braf-mutated cancers hif1an-ampk-pgc1alpha signaling network original author relieving lkb1/ampk/ulk1 axis mitogen-activated protein kinase c-myc-positive melanoma cells amp-activated protein kinase erk-induced cell death—apoptosis developing ampk-specific activators/inhibitors ras/raf-mutated cancer cells lkb1-ampk-ulk1 signaling axis raf induces nf-kappab ras/raf/mek/erk raf/mek/erk inhibitors her2-positive breast cancer treat late-stage braf protein-serine/threonine kinases gtp/gdp exchange factors growth-factor-driven resistance contraction-stimulated signaling nexus jiancheng hu loosens raf/mek heterodimerization k-ras mutant tumors treating raf-mutated cancers microbial alkaloid k-252a treating ras-mutated cancers raf ser/thr kinase m-ras/r-ras3 myeloid-derived suppressor cells advanced-stage thyroid cancers hippo-yap pathway k-ras giving rise

Questions {❓}

AMP-activated protein kinase: new regulation, new roles?
Besides elevating autophagic flux, does the AMPK signaling plays other roles in the MAPKi-resistance of Ras/RAF-mutated cancers?
Drugging the undruggable RAS: mission possible?
RAS synthetic lethal screens revisited: still seeking the elusive prize?
The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?

Schema {🗺️}

WebPage:
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         description:Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40% human cancer cases. To drive carcinogenesis, this signaling promotes cellular overgrowth by turning on proliferative genes, and simultaneously enables cells to overcome metabolic stress by inhibiting AMPK signaling, a key singular node of cellular metabolism. Recent studies have shown that AMPK signaling can also reversibly regulate hyperactive MAPK signaling in cancer cells by phosphorylating its key components, RAF/KSR family kinases, which affects not only carcinogenesis but also the outcomes of targeted cancer therapies against the MAPK signaling. In this review, we will summarize the current proceedings of how MAPK-AMPK signalings interplay with each other in cancer biology, as well as its implications in clinic cancer treatment with MAPK inhibition and AMPK modulators, and discuss the exploitation of combinatory therapies targeting both MAPK and AMPK as a novel therapeutic intervention.
         datePublished:2020-08-17T00:00:00Z
         dateModified:2020-08-17T00:00:00Z
         pageStart:1
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            Autophagy
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      headline:The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
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         AMPK signaling
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         Tumorigenesis
         Cellular metabolism
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         AMPK inhibitors
         AMPK activators
         Autophagy
         Targeted therapy
         Oncology
         Hematology
         Cancer Research
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               type:PostalAddress
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            address:
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               type:PostalAddress
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      name:Geriatric Department, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China
      name:Shenzhen People’s Hospital, Shenzhen, China
      name:Cancer and Stem Cell Program, Duke-NUS Medical School, Singapore, Singapore
      name:Cancer and Stem Cell Program, Duke-NUS Medical School, Singapore, Singapore
      name:Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore, Singapore

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