We are analyzing https://link.springer.com/article/10.1007/s00018-018-2759-2.

Title:
Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy | Cellular and Molecular Life Sciences
Description:
Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process for the clearance of damaged or superfluous proteins and organelles. Accumulating studies have recently revealed that autophagy is closely related to a variety of types of cancer; however, elucidation of its Janus role of either tumor-suppressive or tumor-promoting still remains to be discovered. In this review, we focus on summarizing the context-dependent role of autophagy and its complicated molecular mechanisms in different types of cancer. Moreover, we discuss a series of small-molecule compounds targeting autophagy-related proteins or the autophagic process for potential cancer therapy. Taken together, these findings would shed new light on exploiting the intricate mechanisms of autophagy and relevant small-molecule compounds as potential anti-cancer drugs to improve targeted cancer therapy.
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Keywords {🔍}

pubmed, google, scholar, article, cas, autophagy, cancer, cell, central, cells, death, inhibitor, mtor, wang, apoptosis, zhang, mol, breast, targeting, autophagic, therapy, kinase, biol, med, carcinoma, pathway, inhibition, chen, liu, protein, nature, smallmolecule, potential, dual, tumor, activation, mtorc, role, nat, res, human, sci, induces, growth, inhibitors, mechanisms, zhou, resistance, rev, beclin,

Topics {✒️}

p-stat3–mir155-3p–crebrf pathway bcr-abl-expressing leukemic cells month download article/chapter k-ras-induced lung tumors dr4/jnk pathway-mediated autophagy amp-activated protein kinase pd-l1/pd1 pathway blockade hif-1α/bnip3 signaling pathway hif-1α/mir-210/bcl-2 pathway natural small-molecule enhancers targeting pro-il-1{beta} transiently-induced protein states relevant small-molecule compounds promoting c-myc dephosphorylation oncogenic ras-induced expression advanced renal-cell carcinoma single-agent antitumor activity ras-mediated oncogenic transformation autophagy–inflammation–cell death axis c-met inhibitor su11274 met/ron inhibitor bms-777607 autophagic membrane-scaffold assembly potential anti-cancer drugs anti-tumor activity obesity-induced ovarian cancer gomes-de-silva lc her2-positive gastric cancer ph-sensitive polymeric nanoparticles hormone-sensitive breast cancer inhibiting akt/mtor axis dual pi3k/mtor inhibitors bravo-san pedro jm autophagic compound database pi3k-akt-mtor pathway 5-nitro-5′-hydroxy-indirubin-3′-oxime ring-substituted halogenated analogs castration-resistant prostate cancer inhibiting cyto-protective autophagy platinum-resistant ovarian cancer small-molecule compounds potentiates cisplatin-induced apoptosis autophagy-related genes atg2b tumor-promoting mechanism targeted cancer therapy tumor cell necrosis p53/dram signaling pathway p53-ros cross-talk reduces tumor growth full article pdf hypoxia-induced autophagy contributes

Questions {❓}

Yan C, Yang JM (2013) Autophagy and apoptosis: rivals or mates?

Schema {🗺️}

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