We are analyzing https://link.springer.com/article/10.1007/s12282-018-0920-2.

Title:
Gene expression profile of peripheral blood mononuclear cells may contribute to the identification and immunological classification of breast cancer patients | Breast Cancer
Description:
Background It has been reported that the gene expression profile of peripheral blood mononuclear cells (PBMCs) exhibits a unique gene expression signature in several types of cancer. In this study, we aimed to explore the breast cancer patient-specific gene expression profile of PBMCs and discuss immunological insight on host antitumor immune responses. Methods We comprehensively analyzed the gene expression of PBMCs by RNA sequencing in the breast cancer patients as compared to that of healthy volunteers (HVs). Pathway enrichment analysis was performed on MetaCoretm to search the molecular pathways associated with the gene expression profile of PBMCs in cancer patients compared with HVs. Results We found a significant unique gene expression signature, such as the Toll-like receptor (TLR) 3- and TLR4-induced Toll/interleukin-1 receptor domain-containing adapter molecule 1 (TICAM1)-specific signaling pathway in the breast cancer patients as compared to that of healthy volunteers. Distinctive immunological gene expression profiles also showed the possibility of classifying breast cancer patients into subgroups such as T-cell inhibitory and monocyte-activating groups independent of known phenotypes of breast cancer. Conclusions These preliminary findings suggest that evaluation of gene expression patterns of PBMCs might be both a less invasive diagnostic procedure and a useful way to reveal immunological insight of breast cancer, including biomarkers for cancer immunotherapy, such as immune checkpoint inhibitor therapy.
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Keywords {🔍}

article, pubmed, cancer, google, scholar, breast, cas, gene, expression, patients, profile, cells, immune, central, immunological, access, peripheral, blood, mononuclear, author, privacy, cookies, content, search, pbmcs, pathway, receptor, cell, kyoto, supplementary, material, analysis, data, publish, research, suzuki, sugimoto, kawaguchi, tolllike, open, chen, university, information, log, journal, identification, october, eiji, masahiro, kosuke,

Topics {✒️}

gene expression profile gene expression profiles rna sequencing ryuji uozumi immune gene expression masahiro sugimoto author information authors kosuke kawaguchi double-stranded rna author correspondence adapter molecule 1 gene expression patterns myeloid-derived suppressor cells month download article/chapter nf-kappab gene expression interleukin-17-producing cell infiltration monocyte-activating groups independent helper t-cell response open-source system important immune checkpoints immune system decide full article pdf innate immune system breast cancer patients breast cancer tils check access instant access privacy choices/manage cookies related subjects transcriptional profiling pathway enrichment analysis specific signaling pathway vaccine-specific antibodies monocyte/macrophage infiltration nat rev cancer sugimoto kawaguchi t-cell inhibitory t-cell subsets nonmalignant lung disease acute lung injury article suzuki european economic area discuss immunological insight preliminary findings suggest invasive diagnostic procedure reveal immunological insight immunological potential markers oude egbrink mg

Questions {❓}

Immunological decision-making: how does the immune system decide to mount a helper T-cell response?

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         headline:Gene expression profile of peripheral blood mononuclear cells may contribute to the identification and immunological classification of breast cancer patients
         description:It has been reported that the gene expression profile of peripheral blood mononuclear cells (PBMCs) exhibits a unique gene expression signature in several types of cancer. In this study, we aimed to explore the breast cancer patient-specific gene expression profile of PBMCs and discuss immunological insight on host antitumor immune responses. We comprehensively analyzed the gene expression of PBMCs by RNA sequencing in the breast cancer patients as compared to that of healthy volunteers (HVs). Pathway enrichment analysis was performed on MetaCoretm to search the molecular pathways associated with the gene expression profile of PBMCs in cancer patients compared with HVs. We found a significant unique gene expression signature, such as the Toll-like receptor (TLR) 3- and TLR4-induced Toll/interleukin-1 receptor domain-containing adapter molecule 1 (TICAM1)-specific signaling pathway in the breast cancer patients as compared to that of healthy volunteers. Distinctive immunological gene expression profiles also showed the possibility of classifying breast cancer patients into subgroups such as T-cell inhibitory and monocyte-activating groups independent of known phenotypes of breast cancer. These preliminary findings suggest that evaluation of gene expression patterns of PBMCs might be both a less invasive diagnostic procedure and a useful way to reveal immunological insight of breast cancer, including biomarkers for cancer immunotherapy, such as immune checkpoint inhibitor therapy.
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            Gene expression profile
            RNA sequencing
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            Immune checkpoint molecule
            Surgical Oncology
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            Surgery
            Cancer Research
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         Cancer Research
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