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Keywords {🔍}

pubmed, article, google, scholar, cell, cas, cancer, cells, apoptosis, pathway, signaling, central, death, autophagy, ripk, caspase, tumor, necroptosis, wang, zhang, mtor, induces, pathways, chen, complex, activation, pyroptosis, kinase, targeting, pcd, ferroptosis, liu, treatment, protein, biol, antitumor, growth, induce, inhibits, target, inducing, expression, caspases, tumors, inhibitor, mitochondrial, human, role, carcinoma, drugs,

Topics {✒️}

mir-18a-3p/akt/mtor signaling pathway ros/nf-kappab/nlrp3/gsdmd signal axis ros/nf-κb/nlrp3/gsdmd signaling axis pi3k/akt/m-tor signal pathway notch1/pten/pi3k/akt/mtor pathway pi3k/akt/mtor signalling pathway ros-dependent ampk/mtor/ulk-1 pathway erk/nf-kappab signalling participate mir-30d/pi3k/akt/mtor ripk/nf-κb signaling pathway mir-7/m-tor/srebp1 pathway igf-1/pi3k/akt signaling pathway pi3k/akt/mtor pathway alterations tgf-β-activated kinase 1 akt/mtor/c-myc signaling mir-92a-1-5p/mlkl axis akt/mtor signalling pathway pi3k/akt/mtor signaling pathway regulate mir-7/mtor/srebp1 pathway checkpoint nano-proteolysis-targeting chimeras ampk-mtor-tfeb signaling pathway pi3k/akt/mtor pathway inhibitors inactivating pi3k/akt/mtor pathway regulating akt/beta-catenin pathway ros-inhibited akt/mtor pathway ripk1/ripk3/mklk signaling pathway mediating ros/ampk/mtor pathway ripk1/ripk3/mlkl signaling related regulates erk/mtor-mediated autophagy amp-activated protein kinase ros/erk/mtor signaling pathways ripk1/ripk3/mlkl pathway initiates ripk1/ripk3/mlkl signaling pathway endog-dependent src-stat3 phosphorylation nuclear factor-kappab family ros-induced caspase-independent apoptosis rip1 kinase signalling induces ripk1/mlkl-dependent necroptosis atp-competitive mtor inhibitor erk/mtor-mediated autophagy effect pi3k-akt-mtor signaling met/akt/mtor axis pi3k/akt signaling pathway mtor signalling pathway pi3k/akt/mtor pathway mir-1248/tm9sf/mtor axis pi3k/mtor dual inhibitor open-label crown study activating erk/ripk1/ripk3/mlkl mitochondrial outer-membrane permeabilization

Questions {❓}

• PI3K/AKT/mTOR pathway inhibitors: the ideal combination partners for breast cancer therapies?
• The role of necroptosis in cancer: a double-edged sword?
• The role of pyroptosis in cancer: pro-cancer or pro-"host"?
• What are caspases 3 and 7 doing upstream of the mitochondria?

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      description:Increasing evidence has shown that programmed cell death (PCD) plays a crucial role in tumorigenesis and cancer progression. The components of PCD are complex and include various mechanisms such as apoptosis, necroptosis, alkaliptosis, oxeiptosis, and anoikis, all of which are interrelated in their functions and regulatory pathways. Given the significance of these processes, it is essential to conduct a comprehensive study on PCD to elucidate its multifaceted nature. Key signaling pathways, particularly the caspase signaling pathway, the RIPK1/RIPK3/MLKL pathway, and the mTOR signaling pathway, are pivotal in regulating PCD and influencing tumor progression. In this review, we briefly describe the generation mechanisms of different PCD components and focus on the regulatory mechanisms of these three major signaling pathways within the context of global PCD. Furthermore, we discuss various tumor therapeutic compounds that target different signaling axes of these pathways, which may provide novel strategies for effective tumor therapy and help improve patient outcomes in cancer treatment.
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               type:PostalAddress
            type:Organization
            name:Jiangxi Medical College, Nanchang University
            address:
               name:The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China
      name:HuanKui Academy, Jiangxi Medical College, Nanchang, China
      name:The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China
      name:HuanKui Academy, Jiangxi Medical College, Nanchang, China
      name:The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China
      name:HuanKui Academy, Jiangxi Medical College, Nanchang, China
      name:The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China
      name:Jiangxi Province Key Laboratory of Neurological Diseases, Nanchang, China
      name:The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China
      name:Jiangxi Province Key Laboratory of Neurological Diseases, Nanchang, China
      name:JXHC Key Laboratory of Neurological Medicine, Nanchang, China
      name:Institute of Neuroscience, Jiangxi Medical College, Nanchang University, Nanchang, China
      name:The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China
      name:The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China
      name:Jiangxi Province Key Laboratory of Neurological Diseases, Nanchang, China
      name:JXHC Key Laboratory of Neurological Medicine, Nanchang, China
      name:Institute of Neuroscience, Jiangxi Medical College, Nanchang University, Nanchang, China
      name:The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang, China

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