
NCBI . NLM . NIH . GOV {
}
Title[redir]:
The mTOR Signalling Pathway in Human Cancer - PMC
Description:
The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to rapamycin, activates S6K1 and 4EBP1, ...
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Keywords {๐}
doi, google, scholar, pubmed, mtor, mtorc, cancer, cell, rapamycin, kinase, pathway, pmc, protein, article, free, growth, akt, activation, melanoma, inhibitors, signalling, activity, inhibitor, target, biol, phosphorylation, res, cells, factor, mammalian, pten, complex, tor, breast, ebp, signaling, human, translation, pik, inhibition, activated, regulation, phase, treatment, expression, temsirolimus, regulates, therapy, response, tsc,
Topics {โ๏ธ}
heat shock protein glycogen synthase [25] glycogen synthase proline-rich akt substrate hypoxia-inducible factor 1ฮฑ heat shock [37] hypoxia-inducible transcription factor ras/raf/mek/erk phe-glu-met-asp-ile including gsk3 amp-activated protein kinase stress-activated protein kinase phe-asp-ile-asp-leu 3-phosphoinositide-dependent protein kinase v-ras hypoxia-inducible gene redd1 insulin receptor substrate-1 g1-arresting rapamycin-receptor complex mtor-interacting protein [16] translation inhibitor 4e-bp1 akt/pkb substrate pras40 growth factor receptor pi3k-related protein kinase b-raf inhibitor bay43-9006 serine/threonine kinase p70s6k1 translation elongation factor-2 4e-binding protein 1 phosphoinositide 3-kinase/akt pathway pkb/akt-dependent cell survival multi-targeted kinase inhibitor serine/threonine kinase mtor intracellular receptor fkbp12 akt/nf-ฮบb pathway phosphatidylinositol 3-kinase/mtor pathway activates erk/rsk pathway p70 s6 kinase ras/mapk signaling cascade akt/protein kinase nuclear factor ฮบb nuclear factor-ฮบb mtorc1 protein kinase 70-kda s6 kinase mutant v600eb-raf cooperate nuclear receptor pparฮณ fkbp12-rapamycin-binding site tamoxifen anti-tumor activity usa food mtor/s6 kinase phosphoinositide 3-kinase pathway high-affinity binding site
Questions {โ}
- Renewing the conspiracy theory debate: Does Raf function alone to mediate Ras oncogenesis?
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- Monthly income for https://doi.org/10.1038/nrd2062
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- https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&title=Quantitative%20phosphorylation%20profiling%20of%20the%20ERK/p90%20ribosomal%20S6%20kinase-signaling%20cassette%20and%20its%20targets,%20the%20tuberous%20sclerosis%20tumor%20suppressors&author=B.A.%20Ballif&author=P.P.%20Roux&author=S.A.%20Gerber&author=J.P.%20MacKeigan&author=J.%20Blenis&volume=102&publication_year=2005&pages=667-672&pmid=15647351&doi=10.1073/pnas.0409143102& income
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- What is the monthly revenue of https://doi.org/10.1083/jcb.200112015?
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- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Gynecol.%20Oncol&title=Activation%20of%20mTOR%20signaling%20pathway%20associated%20with%20adverse%20prognostic%20factors%20of%20epithelial%20ovarian%20cancer&author=J.H.%20No&author=Y.T.%20Jeon&author=I.A.%20Park&author=Y.B.%20Kim&author=J.W.%20Kim&volume=121&publication_year=2011&pages=8-12&pmid=21276607&doi=10.1016/j.ygyno.2010.12.364&
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- How much money does https://scholar.google.com/scholar_lookup?journal=Pigment%20Cell%20Melanoma%20Res&title=mTOR%20pathway%20activation%20in%20cutaneous%20melanoma%20is%20associated%20with%20poorer%20prognosis%20characteristics&author=H.%20Populo&author=P.%20Soares&author=A.%20Faustino&author=A.S.%20Rocha&author=P.%20Silva&volume=24&publication_year=2011&pages=254-257&pmid=21029395&doi=10.1111/j.1755-148X.2010.00796.x& generate?
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- https://doi.org/10.1002/cncr.22677's financial summary
- What are the earnings of https://scholar.google.com/scholar_lookup?journal=Cancer&title=Prognostic%20relevance%20of%20the%20mTOR%20pathway%20in%20renal%20cell%20carcinoma:%20Implications%20for%20molecular%20patient%20selection%20for%20targeted%20therapy&author=A.J.%20Pantuck&author=D.B.%20Seligson&author=T.%20Klatte&author=H.%20Yu&author=J.T.%20Leppert&volume=109&publication_year=2007&pages=2257-2267&pmid=17440983&doi=10.1002/cncr.22677&?
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- How much income does https://doi.org/10.1038/ng1494 have?
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- What's the income generated by https://doi.org/10.1111/j.1755-148X.2009.00585.x each month?
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- https://doi.org/10.1055/s-2002-25298 income
- How much income does https://scholar.google.com/scholar_lookup?journal=Semin.%20Respir.%20Crit.%20Care%20Med&title=Lymphangioleiomyomatosis&author=S.R.%20Johnson&author=A.E.%20Tattersfield&volume=23&publication_year=2002&pages=85-92&pmid=16088601&doi=10.1055/s-2002-25298& have?
- What's the revenue for https://doi.org/10.1046/j.1469-1809.2003.00012.x?
- How much does https://scholar.google.com/scholar_lookup?journal=Ann.%20Hum.%20Genet&title=Tuberous%20sclerosis:%20From%20tubers%20to%20mTOR&author=D.J.%20Kwiatkowski&volume=67&publication_year=2003&pages=87-96&pmid=12556239&doi=10.1046/j.1469-1809.2003.00012.x& bring in each month?
- https://doi.org/10.1042/bst0310573 income
- How much does https://scholar.google.com/scholar_lookup?journal=Biochem.%20Soc.%20Trans&title=United%20at%20last:%20The%20tuberous%20sclerosis%20complex%20gene%20products%20connect%20the%20phosphoinositide%203-kinase/Akt%20pathway%20to%20mammalian%20target%20of%20rapamycin%20(mTOR)%20signalling&author=B.D.%20Manning&author=L.C.%20Cantley&volume=31&publication_year=2003&pages=573-578&pmid=12773158&doi=10.1042/bst0310573& pull in monthly?
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- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=The%20LKB1%20tumor%20suppressor%20negatively%20regulates%20mTOR%20signaling&author=R.J.%20Shaw&author=N.%20Bardeesy&author=B.D.%20Manning&author=L.%20Lopez&author=M.%20Kosmatka&volume=6&publication_year=2004&pages=91-99&pmid=15261145&doi=10.1016/j.ccr.2004.06.007&
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- How much does https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl.%20Acad.%20Sci.%20USA&title=The%20NF1%20tumor%20suppressor%20critically%20regulates%20TSC2%20and%20mTOR&author=C.M.%20Johannessen&author=E.E.%20Reczek&author=M.F.%20James&author=H.%20Brems&author=E.%20Legius&volume=102&publication_year=2005&pages=8573-8578&pmid=15937108&doi=10.1073/pnas.0503224102& make?
- See how much https://doi.org/10.1111/j.1600-0463.2007.apm_855.xml.x makes per month
- What's the monthly money flow for https://scholar.google.com/scholar_lookup?journal=Apmis&title=The%20genome%20and%20epigenome%20of%20malignant%20melanoma&author=C.%20Dahl&author=P.%20Guldberg&volume=115&publication_year=2007&pages=1161-1176&pmid=18042149&doi=10.1111/j.1600-0463.2007.apm_855.xml.x&?
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- How much income does https://doi.org/10.1038/sj.onc.1206451 have?
- Financial intake of https://scholar.google.com/scholar_lookup?journal=Oncogene&title=PTEN%20signaling%20pathways%20in%20melanoma&author=H.%20Wu&author=V.%20Goel&author=F.G.%20Haluska&volume=22&publication_year=2003&pages=3113-3122&pmid=12789288&doi=10.1038/sj.onc.1206451&
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- How much money does https://scholar.google.com/scholar_lookup?journal=Virchows%20Arch&title=Allelic%20losses%20on%20chromosome%20arm%2010q%20and%20mutation%20of%20the%20PTEN%20(MMAC1)%20tumour%20suppressor%20gene%20in%20primary%20and%20metastatic%20malignant%20melanomas&author=J.%20Reifenberger&author=M.%20Wolter&author=J.%20Bostrom&author=R.%20Buschges&author=K.W.%20Schulte&volume=436&publication_year=2000&pages=487-493&pmid=10881743&doi=10.1007/s004280050477& make?
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- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Relative%20reciprocity%20of%20NRAS%20and%20PTEN/MMAC1%20alterations%20in%20cutaneous%20melanoma%20cell%20lines&author=H.%20Tsao&author=X.%20Zhang&author=K.%20Fowlkes&author=F.G.%20Haluska&volume=60&publication_year=2000&pages=1800-1804&pmid=10766161&?
- Discover the revenue of https://doi.org/10.1046/j.0022-202X.2004.22243.x
- Profit of https://scholar.google.com/scholar_lookup?journal=J.%20Invest.%20Dermatol&title=Genetic%20interaction%20between%20NRAS%20and%20BRAF%20mutations%20and%20PTEN/MMAC1%20inactivation%20in%20melanoma&author=H.%20Tsao&author=V.%20Goel&author=H.%20Wu&author=G.%20Yang&author=F.G.%20Haluska&volume=122&publication_year=2004&pages=337-341&pmid=15009714&doi=10.1046/j.0022-202X.2004.22243.x&
- Explore the financials of https://doi.org/10.1038/sj.bjc.6604637
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Br.%20J.%20Cancer&title=A%20novel%20AKT3%20mutation%20in%20melanoma%20tumours%20and%20cell%20lines&author=M.A.%20Davies&author=K.%20Stemke-Hale&author=C.%20Tellez&author=T.L.%20Calderone&author=W.%20Deng&volume=99&publication_year=2008&pages=1265-1268&pmid=18813315&doi=10.1038/sj.bjc.6604637& generate?
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