
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia - PMC
Description:
The antibody conjugate gemtuzumab ozogamicin (GO; Mylotargยฎ) provides targeted therapy of acute myeloid leukemia (AML), with recent approvals for patients with CD33-positive disease at diagnosis or relapse, as monotherapy or combined with ...
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Keywords {๐}
caspase, doi, cells, aml, pubmed, google, scholar, cell, activation, expression, dna, fig, patients, treatment, fulllength, goinduced, calicheamicin, apoptosis, apoptotic, pmc, bax, leukemia, protein, article, cleavage, bid, free, acute, death, myeloid, data, patient, ngml, response, conformational, gemtuzumab, ozogamicin, processing, activity, supplementary, reduced, levels, results, change, proapoptotic, inhibition, samples, role, zvdvadfmk, dsbs,
Topics {โ๏ธ}
granulocyte-macrophage colony-stimulating factor tailed mann-whitney t-test c-jun nh2-terminal kinase fluorescent secondary donkey-anti-mouse dna double-strand breaks caspase-2 inhibitor z-vdvad-fmk z-vdvad-fmk significantly reduced including heat-labile sites pulsed-field gel electrophoresis goat anti-rabbit-antibodies familjen erling-perssons stiftelse ich-1/cad-3 homologous protein z-vdvad-fmk treatment pmc beta search methods cell culture caspase-3 full-length expressions full-length caspase-3 expressions full-length bid expression full-length caspase-2 protein 1000โbq/ml 14c-thymidine full-length caspase-2 expression full-length caspase-2/-3 expression full-length caspase-3 expression targeted antibody-drug conjugate supplementary information files monoclonal antibody-based therapies caspase-2-mediated apoptotic signaling cell damage-induced conformational fas-mediated cell death z-vdvad-fmk replicative stress-induced apoptosis adding 100โยตg/ml digitonin antibody-targeted chemotherapy agent competing interests 49โkda full-length caspase-2 pro-apoptotic protein bak p53-defective cells triggered regular high-dose chemotherapy direct pro-apoptotic role license information pmcid supplementary figures text functional dna-repair process induced pro-caspase-2 processing dna treatment-induced dsbs er-stress-induced apoptosis [36] anthracycline-based induction therapy data availability statements data availability statement thermo fisher scientific pidd death-domain phosphorylation
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- What's the financial intake of https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=Activation%20of%20caspase-2%20in%20apoptosis&author=H%20Li&author=L%20Bergeron&author=V%20Cryns&author=MS%20Pasternack&author=H%20Zhu&volume=272&publication_year=1997&pages=21010-7&pmid=9261102&doi=10.1074/jbc.272.34.21010&?
- How much does https://doi.org/10.1016/S0092-8674(00)81590-1 net monthly?
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Cell&title=Cleavage%20of%20BID%20by%20caspase%208%20mediates%20the%20mitochondrial%20damage%20in%20the%20Fas%20pathway%20of%20apoptosis&author=H%20Li&author=H%20Zhu&author=CJ%20Xu&author=J%20Yuan&volume=94&publication_year=1998&pages=491-501&pmid=9727492&doi=10.1016/S0092-8674(00)81590-1&?
- How much does https://doi.org/10.1016/S0092-8674(00)81589-5 pull in?
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Cell&title=Bid,%20a%20Bcl2%20interacting%20protein,%20mediates%20cytochrome%20c%20release%20from%20mitochondria%20in%20response%20to%20activation%20of%20cell%20surface%20death%20receptors&author=X%20Luo&author=I%20Budihardjo&author=H%20Zou&author=C%20Slaughter&author=X%20Wang&volume=94&publication_year=1998&pages=481-90&pmid=9727491&doi=10.1016/S0092-8674(00)81589-5&?
- How much revenue does https://doi.org/10.1074/jbc.M108029200 produce monthly?
- How much profit does https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=Caspase-2%20induces%20apoptosis%20by%20releasing%20proapoptotic%20proteins%20from%20mitochondria&author=Y%20Guo&author=SM%20Srinivasula&author=A%20Druilhe&author=T%20Fernandes-Alnemri&author=ES%20Alnemri&volume=277&publication_year=2002&pages=13430-7&pmid=11832478&doi=10.1074/jbc.M108029200& make?
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- https://scholar.google.com/scholar_lookup?journal=Blood.&title=Involvement%20of%20caspase-2%20long%20isoform%20in%20Fas-mediated%20cell%20death%20of%20human%20leukemic%20cells&author=N%20Droin&author=F%20Bichat&author=C%20Rebe&author=A%20Wotawa&author=O%20Sordet&volume=97&publication_year=2001&pages=1835-44.&pmid=11238127&doi=10.1182/blood.V97.6.1835&'s financial summary
- Monthly income for https://doi.org/10.1016/j.cell.2005.06.014
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- How much does https://doi.org/10.1016/j.cell.2005.06.022 pull in?
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- How much income is https://doi.org/10.1016/j.cell.2007.03.017 earning monthly?
- How much does https://scholar.google.com/scholar_lookup?journal=Cell.&title=The%20BH3-only%20protein%20bid%20is%20dispensable%20for%20DNA%20damage-%20and%20replicative%20stress-induced%20apoptosis%20or%20cell-cycle%20arrest&author=T%20Kaufmann&author=L%20Tai&author=PG%20Ekert&author=DC%20Huang&author=F%20Norris&volume=129&publication_year=2007&pages=423-33&pmid=17448999&doi=10.1016/j.cell.2007.03.017& pull in monthly?
- How much revenue does https://doi.org/10.1038/cddis.2013.470 bring in?
- How much income is https://scholar.google.com/scholar_lookup?journal=Cell%20Death%20Dis&title=Death%20of%20p53-defective%20cells%20triggered%20by%20forced%20mitotic%20entry%20in%20the%20presence%20of%20DNA%20damage%20is%20not%20uniquely%20dependent%20on%20Caspase-2%20or%20the%20PIDDosome&author=C%20Manzl&author=LL%20Fava&author=G%20Krumschnabel&author=L%20Peintner&author=MC%20Tanzer&volume=4&publication_year=2013&pages=e942&pmid=24309929&doi=10.1038/cddis.2013.470& earning monthly?
- What's the income of https://doi.org/10.1242/jcs.203448?
- How much does https://scholar.google.com/scholar_lookup?journal=J%20Cell%20Sci&title=The%20resurrection%20of%20the%20PIDDosome%20-%20emerging%20roles%20in%20the%20DNA-damage%20response%20and%20centrosome%20surveillance&author=V%20Sladky&author=F%20Schuler&author=LL%20Fava&author=A%20Villunger&volume=130&publication_year=2017&pages=3779-87.&pmid=29142064&doi=10.1242/jcs.203448& pull in monthly?
- Monthly income for https://doi.org/10.1038/cddis.2016.392
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