
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome - PMC
Description:
Receptor-interacting protein kinase 3 (RIPK3) is a serine/threonine kinase with essential function in necroptosis. The activity of RIPK3 is controlled by phosphorylation. Once activated, RIPK3 phosphorylates and activates the downstream effector ...
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Keywords {🔍}
ripk, cells, cell, death, mlkl, fig, necroptosis, kinase, doi, pubmed, google, scholar, proteasome, apoptosis, pmc, caspase, article, wild, type, expression, bortezomib, free, induced, activation, treated, lys, results, treatment, protein, inhibition, rhim, dox, inhibitor, phosphorylation, ubiquitination, gsk, mginduced, activity, inhibitors, rip, human, complex, domain, ripkexpressing, induction, pathway, necrosis, ripoptosome, induce, ripkdependent,
Topics {✒️}
t231a/s232a mutant-expressing cells 10 μm z-vad-fmk 20 μm z-vad-fmk caspase-mediated p65/rela cleavage z-vad-fmk receptor-interacting protein k48-linked polyubiquitinated ripk3 anti-tnf blocking antibody k48-linked polyubiquitin chain d143n mutant-expressing cells ripk3-expressing 3t3 cells k48-linked ripk3 polyubiquitination anti-mouse ripk3 antibody retroviral pmscv/hyg vector cells expressing ripk3-k264a prevent rhim-mediated oligomerization ripk3-dependent cell death k48-linked ubiquitinated ripk3 ripk3-d143n-expressing cells z-ietd-fmk ripk3-t231a/s232a cells mg132-induced cell death k11-linked polyubiquitin chains author contributions pmc beta search cells expressing ripk3-k264r kinase activity-independent manner gag/pol packaging vectors doxycycline-induced 3t3 cells ubiquitination-mediated ripk3 activation adaptor-inducing interferon β impact ripk3-dependent necroptosis inhibit ripk3-dependent necroptosis mg132-induced ripk3 ubiquitination tnf-induced ripk3 activation reducing sds-page pmc copyright notice mg132-induced mlkl oligomerization normal rabbit igg induces caspase-dependent apoptosis ripk3 kinase inhibitor wild type ripk3 doxycycline-induced ripk3 expression death effector domain serine/threonine kinase anti-ripk3 antibody rip1/rip3 necrosome forms pgipz vector carrying ubiquitin ligase e3 ripk3-mlkl necroptotic pathway
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