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Title[redir]:
Innate immune signaling through differential RIPK1 expression promote tumor progression in head and neck squamous cell carcinoma - PMC
Description:
This study reports the role of RIPK1 in modulating HNSCC metastasis. We find RIPK1 is downregulated during the tumor progression and reduced RIPK1 expression correlates with promoter hypermethylation. In tumor-derived HNSCC cell lines, RIPK1 ...
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Keywords {🔍}
ripk, cells, expression, cell, metastatic, tumor, hnscc, primary, cancer, figure, doi, pipc, methylation, pubmed, google, scholar, signaling, lines, tumors, apoptosis, promoter, tlr, pmc, response, head, neck, downregulation, migration, enhanced, data, pcib, pcia, apoptotic, protein, levels, treatment, derived, free, assay, samples, article, shown, mrna, nfκb, results, death, analysis, normal, compared, paired,
Topics {✒️}
pentr/d-topo flag-ripk1-ha tlr3-nf-κb pro-survival signaling ice-cold phosphate-buffered saline tlr3-nf-κb signaling pathway tlr3-mediated nf-κb signaling nf-κb-target genes compared tlr3-mediated nf-κb activation pci-15a-shripk1 cell lines prosurvival nf-κb signaling activate prosurvival nf-κb pci-15a-shripk1 cells compared tlr3-nf-κb signaling defective nf-kappab signaling encode chip-seq results stimulation activated nf-κb receptor 3-induced nf-kappa p53-independent cell death assay pci-15a-shctrl synthetic double-stranded rnas pmc beta search pci-15a shripk1 cells pci-15a-shripk1-cells pci-15b total rna dimensional wound-healing assay pci-15a-shctrl cells dna free kit methods cell lines nf-κb activity nf-κb activation 2d wound-healing assay transcription factor arid3a primary tumor-derived cells activate nf-κb poly-hema coated wells fibronectin-coated membrane compared pci-15b metastatic cells phosphate-buffered saline normal solid tissue mediated cell death pci-15a-shripk1 double stranded rna double-stranded rna pinducer lentiviral toolkit inducible rna interference double-stranded rnas inhibits cell proliferation molecular biology methods transcription start site hnscc cell lines cell death pathways
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