
NCBI . NLM . NIH . GOV {
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Title[redir]:
YM155, a survivin suppressant, triggers PARP-dependent cell death (parthanatos) and inhibits esophageal squamous-cell carcinoma xenografts in mice - PMC
Description:
Here we demonstrated that sepantronium bromide (YM155), a survivin suppressant, inhibited esophageal squamous-cell carcinoma (ESCC) growth in mice bearing human ESCC xenografts without affecting body weight. In cell culture, YM155 decreased survivin ...
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Keywords {🔍}
kyse, cells, cell, doi, parp, death, treatment, cancer, pubmed, google, scholar, parthanatos, survivin, esophageal, aif, fig, expression, pmc, analysis, article, dna, free, genes, tumor, lines, western, data, analyzed, apoptosis, induces, damage, shown, human, treated, levels, sirna, yminduced, blot, carcinoma, translocation, slcf, results, par, escc, gene, study, protein, parpdependent, assay, untreated,
Topics {✒️}
ym155-induced parp-mediated parthanatos interleukin enhancer-binding factor-3 gene-specific real-time primers n-myc downstream-regulated gene-1 esophageal squamous-cell carcinoma polymer-induced cell death parp-1-dependent parthanatos induced parp-mediated cell death dna-dependent sumo modification produce time-dependent increases ultrasensitive streptavidin-peroxidase system adult t-cell leukemia real-time rt-pcr ym155-induced cell death autophagy-dependent cell death parp-1-dependent cell death ym155-mediated dna damage small-molecule transcriptional repressor polymerase-1-dependent cell death dna double-strand breaks ym155-mediated parthanatos induction biotin-labeled secondary antibody jr parp-mediated repair protein-protein interaction networks cell-cycle phase distribution pmc beta search parp-dependent parthanatos induction robust multi-array average alternative ym155-effected pathway crispr-cas9-based method parp-1-mediated par formation small-molecule survivin suppressant squamous cell carcinoma gov/tools/primer-blast/ solute carrier proteins pathway-directed drug discovery significant time-dependent accumulation cell death dependent parp-mediated parthanatos oxidant-induced parthanatos parthanatos cell death relative gamma-h2ax levels microarray-based screening procedure supplementary materials oncotarget-06-18445-s001 ilf3-p54/nrb complex specific anti-par antibody poly-adp polymer formation mitotracker red cmxros real-time pcr cell protein extract
Questions {❓}
- DNA repair: PARP - another guardian angel?
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