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hematopoietic-acute radiation syndrome springer nature cdgsh iron-sulfur domain ras-jnk signaling pathway ip3r-mcu calcium axis porcine virus-induced injuries sads-cov induced apoptosis zearalenone-induced oxidative stress gpx-independent defense systems cystine transporter slc7a11/xct ipec-j2 cells treated heat stress-induced injury acs central sci deoxynivalenol-induced intestinal damage alleviate cadmium-induced ferroptosis gly-pro-ala peptide 18β-glycyrrhetinic acid protects inhibiting nrf2/ho-1 pathway medium-chain fatty acids prevent hydroperoxide-induced ferroptosis zen-induced reproductive toxicity provide valuable references don-induced intestinal injury iron-dependent lipid peroxidation restrict don-induced ferroptosis glutathione-independent ferroptosis suppressor cerebral ischemia–reperfusion swine influenza virus deoxynivalenol-induced liver injury inhibited don-induced ferroptosis privacy choices/manage cookies ipec-j2 cell model authors scientific editing author information authors oxidative stress induced respiratory syndrome virus activating ampk pathway bmc pig reproductive system improving oxidative stress oxidative stress damage ischemia-reperfusion iec decreasing oxidative stress combat oxidative stress cysteine/glutamate antiporter system dysregulated iron metabolism state privacy rights mycotoxin-induced damage selenium inhibits ferroptosis intestinal damage caused

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         headline:The multifaceted role of ferroptosis in infection and injury and its nutritional regulation in pigs
         description:Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by iron overload and excessive lipid peroxidation. To date, numerous studies in human and mouse models have shown that ferroptosis is closely related to tissue damage and various diseases. In recent years, ferroptosis has also been found to play an indispensable and multifaceted role in infection and tissue injury in pigs, and nutritional regulation strategies targeting ferroptosis show great potential. In this review, we summarize the research progress of ferroptosis and its role in infection and tissue injury in pigs. Furthermore, we discuss the existing evidence on ferroptosis regulation by nutrients, aiming to provide valuable insights for future investigation into ferroptosis in pigs and offer a novel perspective for the treatment of infection and injury in pigs.
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            GPX4
            Nutritional regulation
            Pig
            Agriculture
            Biotechnology
            Food Science
            Animal Genetics and Genomics
            Animal Physiology
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      headline:The multifaceted role of ferroptosis in infection and injury and its nutritional regulation in pigs
      description:Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by iron overload and excessive lipid peroxidation. To date, numerous studies in human and mouse models have shown that ferroptosis is closely related to tissue damage and various diseases. In recent years, ferroptosis has also been found to play an indispensable and multifaceted role in infection and tissue injury in pigs, and nutritional regulation strategies targeting ferroptosis show great potential. In this review, we summarize the research progress of ferroptosis and its role in infection and tissue injury in pigs. Furthermore, we discuss the existing evidence on ferroptosis regulation by nutrients, aiming to provide valuable insights for future investigation into ferroptosis in pigs and offer a novel perspective for the treatment of infection and injury in pigs.
      datePublished:2025-02-25T00:00:00Z
      dateModified:2025-02-25T00:00:00Z
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         Ferroptosis
         GPX4
         Nutritional regulation
         Pig
         Agriculture
         Biotechnology
         Food Science
         Animal Genetics and Genomics
         Animal Physiology
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      name:Kan Xiao
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      name:Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, Wuhan, China
      name:Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, Wuhan, China

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