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We began analyzing https://pubs.acs.org/doi/10.1021/acs.jafc.1c04411, but it redirected us to https://pubs.acs.org/doi/10.1021/acs.jafc.1c04411. The analysis below is for the second page.
Title[redir]:
Exogenous Iron Induces NADPH Oxidases-Dependent Ferroptosis in the Conidia of Aspergillus flavus | Journal of Agricultural and Food Chemistry
Description:
Aspergillus flavus is saprophytic soil fungus that contaminates seed crops with the carcinogenic secondary metabolite aflatoxin, posing a significant threat to humans and animals. Ferrous sulfate is a common iron supplement that is used to the treatment of iron-deficiency anemia. Here, we identified an unexpected inhibitory role of ferrous sulfate on A. flavus. With specific fluorescent dyes, we detected several conidial ferroptosis hallmarks in conidia under the treatment of 1 mM Fe2+, including nonapoptosis necrosis, iron-dependent, lipid peroxide accumulation, and ROS burst. However, unlike traditional ferroptosis in mammals, Fe2+ triggered conidial ferroptosis in A. flavus was regulated by NADPH oxidase (NOXs) activation instead of Fenton reaction. Transcriptomic and some other bioinformatics analyses showed that NoxA in A. flavus might be a potential target of Fe2+, and thus led to the occurrence of conidial ferroptosis. Furthermore, noxA deletion mutant was constructed, and both ROS generation and conidial ferroptosis in ΞnoxA was reduced when exposed to Fe2+. Taken together, our study revealed an exogenous Fe2+-triggered conidial ferroptosis pathway mediated by NoxA of A. flavus, which greatly contributes to the development of an alternative strategy to control this pathogen.
Title[redir]:
Exogenous Iron Induces NADPH Oxidases-Dependent Ferroptosis in the Conidia of Aspergillus flavus | Journal of Agricultural and Food Chemistry
Description:
Aspergillus flavus is saprophytic soil fungus that contaminates seed crops with the carcinogenic secondary metabolite aflatoxin, posing a significant threat to humans and animals. Ferrous sulfate is a common iron supplement that is used to the treatment of iron-deficiency anemia. Here, we identified an unexpected inhibitory role of ferrous sulfate on A. flavus. With specific fluorescent dyes, we detected several conidial ferroptosis hallmarks in conidia under the treatment of 1 mM Fe2+, including nonapoptosis necrosis, iron-dependent, lipid peroxide accumulation, and ROS burst. However, unlike traditional ferroptosis in mammals, Fe2+ triggered conidial ferroptosis in A. flavus was regulated by NADPH oxidase (NOXs) activation instead of Fenton reaction. Transcriptomic and some other bioinformatics analyses showed that NoxA in A. flavus might be a potential target of Fe2+, and thus led to the occurrence of conidial ferroptosis. Furthermore, noxA deletion mutant was constructed, and both ROS generation and conidial ferroptosis in ΞnoxA was reduced when exposed to Fe2+. Taken together, our study revealed an exogenous Fe2+-triggered conidial ferroptosis pathway mediated by NoxA of A. flavus, which greatly contributes to the development of an alternative strategy to control this pathogen.
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Keywords {π}
ferroptosis, zhang, acs, flavus, article, hongbo, haizhen, liangbin, journal, food, lishan, access, peng, liu, wang, aspergillus, shurui, yao, dan, postharvest, wei, publications, zhou, information, conidial, chemistry, infection, zhenbin, nadph, conidia, supporting, ferrous, zhu, cell, yang, institution, log, agricultural, exogenous, iron, induces, options, aflatoxin, noxa, copyright, american, chemical, society, system, jiayi,
Topics {βοΈ}
org/page/copyright/permissions osa-starch pickering emulsion acs acs publications aflatoxin b1-related toxicity ferroptosis-protective membrane domains cures vulvovaginal candidiasis acs member benefits acs web editions common iron supplement iron-deficiency anemia acs publications iron-dependent terms & conditions 4c01584 bei zhou food chemistry cite nadph oxidase estragole inhibits growth conidial ferroptosis hallmarks rightslink permission system xiaohui zhou postharvest fruit rot heals wound infection unlike traditional ferroptosis en cas find saprophytic soil fungus contaminates seed crops including nonapoptosis necrosis bioinformatics analyses showed 1186/s40104-025-01165-1 isuru ekanayake 1515/pac-2024-0272 shuang gu cheol-sang hwang inhibiting fungal growth triggering fruit defense 3390/foods12183458 liuke liang hylocereus undulatus britt expand food safety liang-bin hu promising therapeutic targets targeted therapeutic approaches 3390/molecules28010243 lishan yao specific fluorescent dyes lipid peroxide accumulation 3390/antiox13040452 qing shen bacterial cell death acs id hong-bo li jia-yi zhang ferrous sulfate unexpected inhibitory role fenton reaction
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