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DOI . ORG {}

Detected CMS Systems:

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Social Networks
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://pubs.acs.org/doi/10.1021/acs.jafc.3c02027, but it redirected us to https://pubs.acs.org/doi/10.1021/acs.jafc.3c02027. The analysis below is for the second page.

Title[redir]:
Quercetin Alleviates Deoxynivalenol-Induced Intestinal Damage by Suppressing Inflammation and Ferroptosis in Mice | Journal of Agricultural and Food Chemistry
Description:
Deoxynivalenol (DON), one of the most prevalent mycotoxins found in food and feed, can cause gastrointestinal inflammation and systemic immunosuppression, presenting a serious hazard to human and animal health. Quercetin (QUE) is a plant polyphenol with anti-inflammatory and antioxidant properties. In this research, we investigated the potential function of QUE as a treatment for DON-induced intestinal damage. Thirty male specific-pathogen-free BALB/c mice were randomly allocated to treatment with QUE (50 mg/kg) and/or DON (0, 0.5, 1, and 2 mg/kg). We found that QUE attenuated DON-induced intestinal damage in mice by improving jejunal structural injury and changing tight junction proteins (claudin-1, claudin-3, ZO-1, and occludin) levels. QUE also suppressed DON-triggered intestinal inflammation by inhibiting the TLR4/NF-κB signaling pathway. Meanwhile, QUE decreased the oxidative stress caused by DON by enhancing the concentrations of SOD and GSH, while diminishing the contents of MDA. In particular, QUE reduced DON-induced intestinal ferroptosis. DON-induced intestinal damage elevated TfR and 4HNE levels, along with transcription levels of ferroptosis-related genes (PTGS2, ACSL4, and HAMP1) while diminishing mRNA levels of FTH1, SLC7A11, GPX4, FPN1, and FSP1, all of which were reversed by QUE treatment. Our findings imply that QUE alleviates DON-induced intestinal injury in mice by inhibiting the TLR4/NF-κB signaling pathway and ferroptosis. In this study, we elucidate the toxicological mechanism of DON, provide a basic foundation or theory for future DON prevention and treatment, and explore strategies to prevent and alleviate DON’s hazardous effects.

Matching Content Categories {📚}

  • Health & Fitness
  • Science
  • Insurance

Content Management System {📝}

What CMS is doi.org built with?


Doi.org is built with XENFORO.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 76,079,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We see no obvious way the site makes money.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Doi.org has a secret sauce for making money, but we can't detect it yet.

Keywords {🔍}

liu, wang, acs, journal, intestinal, ferroptosis, zhang, mice, food, injury, chen, article, quercetin, access, deoxynivalenol, deoxynivalenolinduced, damage, inflammation, yang, don, doninduced, signaling, chemical, jiang, mechanisms, jun, zhou, toxicity, toxicology, publications, agricultural, alleviates, information, treatment, inflammatory, liver, zhu, supporting, levels, pathway, chemistry, httpsdoiorgacsjafcc, aimei, song, ruan, hao, ferritinophagy, pharmacology, protects, redox,

Topics {✒️}

ros/tlr4/nf-κb pathway tlr4/nf-κb signaling pathway plant extract-based remedies org/page/copyright/permissions deoxynivalenol-induced liver injury don-induced intestinal damage 18β-glycyrrhetinic acid protects dap-induced liver injury afb1-induced oxidative stress gut–brain axis disorders hesperidin modulated o-glcnacylation sequence-targeted quercetin delivery acs acs publications targeting inflammation-related diseases elaine lai-han leung quercetin alleviates lps/ induced liver injury ferroptosis-modulating natural products network pharmacology identifying integrating network pharmacology multiple intestinal toxicity porcine intestinal injury deoxynivalenol-induced pyroptosis inhibiting gpx4-dependent ferroptosis acs member benefits acs web editions oxidative stress caused terms & conditions acs publications intestinal barrier function ferroptosis-related genes ferroptosis-related factors food chemistry cite manipulating redox signaling natural phenolic compounds hon-ho yu en cas find qrt-pcr examination gea oliveri conti intracellular iron efflux mouse neuronal cells 0556 ieng-hou lam mitochondrial quality control angela trovato salinaro 3390/antiox13040484 nemanja živanović multi-omics reveals simulating ozone degradation 3390/antiox14020236 baolan wang 1515/med-2024-0993 yebo wang inflammatory damage

Social Networks {👍}(2)

External Links {🔗}(100)

Analytics and Tracking {📊}

  • Facebook Pixel
  • Google Analytics
  • Google Analytics 4
  • Google Tag Manager
  • Hotjar
  • Microsoft Clarity
  • Site Verification - Google

Libraries {📚}

  • Dropzone.js
  • jQuery
  • Knockout.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Cloudflare

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