Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We are analyzing https://www.nature.com/articles/ncomms15628.

Title:
JunB is essential for IL-23-dependent pathogenicity of Th17 cells | Nature Communications
Description:
CD4+ T-helper cells producing interleukin-17 (IL-17), known as T-helper 17 (TH17) cells, comprise heterogeneous subsets that exhibit distinct pathogenicity. Although pathogenic and non-pathogenic TH17 subsets share a common RORγt-dependent TH17 transcriptional programme, transcriptional regulatory mechanisms specific to each of these subsets are mostly unknown. Here we show that the AP-1 transcription factor JunB is critical for TH17 pathogenicity. JunB, which is induced by IL-6, is essential for expression of RORγt and IL-23 receptor by facilitating DNA binding of BATF at the Rorc locus in IL-23-dependent pathogenic TH17 cells, but not in TGF-β1-dependent non-pathogenic TH17 cells. Junb-deficient T cells fail to induce TH17-mediated autoimmune encephalomyelitis and colitis. However, JunB deficiency does not affect the abundance of gut-resident non-pathogenic TH17 cells. The selective requirement of JunB for IL-23-dependent TH17 pathogenicity suggests that the JunB-dependent pathway may be a therapeutic target for autoimmune diseases. T helper 17 (Th17) cells can be pathogenic, but what controls this phenotype is unclear. Here the authors show that the transcription factor JunB promotes proinflammatory Th17 function by regulating the transcription of multiple Th17-related genes.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Science
  • Education
  • Social Networks

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🚀🌠 Tremendous Traffic: 10M - 20M visitors per month


Based on our best estimate, this website will receive around 16,942,715 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$213,500 per month
Estimations show Nature.com's display ad online revenue falls between $142,361 and $391,492 per month.

Keywords {🔍}

cells, junb, pubmed, fig, article, mice, conditions, google, scholar, expression, supplementary, cas, thβ, induction, data, transcription, central, ila, nature, pathogenicity, cell, differentiation, batf, junbdeficient, rorγt, pathogenic, genes, control, irf, analysis, ildependent, stat, thpolarizing, activated, cdcrejunbflfl, biolegend, dna, nonpathogenic, tgfβ, factor, induced, foxp, function, signalling, binding, rorc, required, production, deficiency, inhibitor,

Topics {✒️}

nature portfolio privacy policy npo biotechnology research thermo fisher scientific editing th17-derived ifn-γ-producing cells advertising immune-specific ap-1-irf complexes junb-deficient th17-fate-mapping reporter cancer research chromatin solutions generated t-cell-specific junb-deficient horseradish peroxidase-conjugated anti-mouse wnt/β-catenin signaling contributes il-17a single-producing cells ifn-γ single-producing cells ires-driven complementary dna tgf-β1-dependent rorγt induction47 0/ reprints phycoerythrin-labelled il-17-secreting cells open boxes transferring junb-deficient cd4+cd45rbhicd25− eyfp+cd4+ t-cell population tgf-beta-induced foxp3 inhibits il-6/il-1β/il-23-induced th17 transforming-growth factor-beta plate-bound anti-cd3 antibody single base-pair resolution generate t-cell-specific pathogenic interferon-gamma-producing vivo th17-fate-mapping data ap-1-irf composite elements ap-1-irf composite elements33 tgf-β1-dependent th17 cells tgf-β/il-6-induced th17 cells t-cell receptor signalling cell-specific stat3-deficient mice junb-dependent il-23r induction tgf-β1/il-6-induced th17 anti-cd3 antibody treatment myelin oligodendrocyte glycoprotein-specific performed th17-fate-mapping analysis remove excess adaptor-dimer central nervous system cell-dependent iga responses transferring cd4+cd45rbhicd25− cells soluble anti-cd28 antibody library preparation library quantification il-17a-expressing cd4+

Schema {🗺️}

WebPage:
      mainEntity:
         headline:JunB is essential for IL-23-dependent pathogenicity of Th17 cells
         description:CD4+ T-helper cells producing interleukin-17 (IL-17), known as T-helper 17 (TH17) cells, comprise heterogeneous subsets that exhibit distinct pathogenicity. Although pathogenic and non-pathogenic TH17 subsets share a common RORγt-dependent TH17 transcriptional programme, transcriptional regulatory mechanisms specific to each of these subsets are mostly unknown. Here we show that the AP-1 transcription factor JunB is critical for TH17 pathogenicity. JunB, which is induced by IL-6, is essential for expression of RORγt and IL-23 receptor by facilitating DNA binding of BATF at the Rorc locus in IL-23-dependent pathogenic TH17 cells, but not in TGF-β1-dependent non-pathogenic TH17 cells. Junb-deficient T cells fail to induce TH17-mediated autoimmune encephalomyelitis and colitis. However, JunB deficiency does not affect the abundance of gut-resident non-pathogenic TH17 cells. The selective requirement of JunB for IL-23-dependent TH17 pathogenicity suggests that the JunB-dependent pathway may be a therapeutic target for autoimmune diseases. T helper 17 (Th17) cells can be pathogenic, but what controls this phenotype is unclear. Here the authors show that the transcription factor JunB promotes proinflammatory Th17 function by regulating the transcription of multiple Th17-related genes.
         datePublished:2017-05-30T00:00:00Z
         dateModified:2017-05-30T00:00:00Z
         pageStart:1
         pageEnd:12
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/ncomms15628
         keywords:
            Autoimmunity
            Immunogenetics
            Neuroimmunology
            T-helper 17 cells
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig6_HTML.jpg
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:8
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Zafrul Hasan
               affiliation:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                     address:
                        name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shin-ichi Koizumi
               affiliation:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                     address:
                        name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daiki Sasaki
               affiliation:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                     address:
                        name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hayato Yamada
               affiliation:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                     address:
                        name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nana Arakaki
               affiliation:
                     name:DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University
                     address:
                        name:DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yoshitaka Fujihara
               affiliation:
                     name:Research Institute for Microbial Diseases, Osaka University
                     address:
                        name:Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shiho Okitsu
               affiliation:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                     address:
                        name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hiroki Shirahata
               affiliation:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                     address:
                        name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hiroki Ishikawa
               affiliation:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                     address:
                        name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:JunB is essential for IL-23-dependent pathogenicity of Th17 cells
      description:CD4+ T-helper cells producing interleukin-17 (IL-17), known as T-helper 17 (TH17) cells, comprise heterogeneous subsets that exhibit distinct pathogenicity. Although pathogenic and non-pathogenic TH17 subsets share a common RORγt-dependent TH17 transcriptional programme, transcriptional regulatory mechanisms specific to each of these subsets are mostly unknown. Here we show that the AP-1 transcription factor JunB is critical for TH17 pathogenicity. JunB, which is induced by IL-6, is essential for expression of RORγt and IL-23 receptor by facilitating DNA binding of BATF at the Rorc locus in IL-23-dependent pathogenic TH17 cells, but not in TGF-β1-dependent non-pathogenic TH17 cells. Junb-deficient T cells fail to induce TH17-mediated autoimmune encephalomyelitis and colitis. However, JunB deficiency does not affect the abundance of gut-resident non-pathogenic TH17 cells. The selective requirement of JunB for IL-23-dependent TH17 pathogenicity suggests that the JunB-dependent pathway may be a therapeutic target for autoimmune diseases. T helper 17 (Th17) cells can be pathogenic, but what controls this phenotype is unclear. Here the authors show that the transcription factor JunB promotes proinflammatory Th17 function by regulating the transcription of multiple Th17-related genes.
      datePublished:2017-05-30T00:00:00Z
      dateModified:2017-05-30T00:00:00Z
      pageStart:1
      pageEnd:12
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/ncomms15628
      keywords:
         Autoimmunity
         Immunogenetics
         Neuroimmunology
         T-helper 17 cells
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fncomms15628/MediaObjects/41467_2017_Article_BFncomms15628_Fig6_HTML.jpg
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:8
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Zafrul Hasan
            affiliation:
                  name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                  address:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shin-ichi Koizumi
            affiliation:
                  name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                  address:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daiki Sasaki
            affiliation:
                  name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                  address:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hayato Yamada
            affiliation:
                  name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                  address:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nana Arakaki
            affiliation:
                  name:DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University
                  address:
                     name:DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yoshitaka Fujihara
            affiliation:
                  name:Research Institute for Microbial Diseases, Osaka University
                  address:
                     name:Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shiho Okitsu
            affiliation:
                  name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                  address:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hiroki Shirahata
            affiliation:
                  name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                  address:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hiroki Ishikawa
            affiliation:
                  name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
                  address:
                     name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:8
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
      address:
         name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
         type:PostalAddress
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
      address:
         name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
         type:PostalAddress
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
      address:
         name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
         type:PostalAddress
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
      address:
         name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
         type:PostalAddress
      name:DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University
      address:
         name:DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
         type:PostalAddress
      name:Research Institute for Microbial Diseases, Osaka University
      address:
         name:Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
         type:PostalAddress
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
      address:
         name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
         type:PostalAddress
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
      address:
         name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
         type:PostalAddress
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
      address:
         name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Zafrul Hasan
      affiliation:
            name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
            address:
               name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Shin-ichi Koizumi
      affiliation:
            name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
            address:
               name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Daiki Sasaki
      affiliation:
            name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
            address:
               name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Hayato Yamada
      affiliation:
            name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
            address:
               name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Nana Arakaki
      affiliation:
            name:DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University
            address:
               name:DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Yoshitaka Fujihara
      affiliation:
            name:Research Institute for Microbial Diseases, Osaka University
            address:
               name:Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
               type:PostalAddress
            type:Organization
      name:Shiho Okitsu
      affiliation:
            name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
            address:
               name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Hiroki Shirahata
      affiliation:
            name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
            address:
               name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
               type:PostalAddress
            type:Organization
      name:Hiroki Ishikawa
      affiliation:
            name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University
            address:
               name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
      name:DNA Sequencing Section, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
      name:Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan
      name:Immune Signal Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan

External Links {🔗}(234)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

6.06s.