
NCBI . NLM . NIH . GOV {
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Title[redir]:
Induction and molecular signature of pathogenic TH17 cells - PMC
Description:
Interleukin 17 (IL-17)-producing TH17 cells are often present at the sites of tissue inflammation in autoimmune diseases, which has lead to the conclusion that TH17 are main drivers of autoimmune tissue injury. However, not all TH17 cells are ...
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Keywords {🔍}
cells, tgfβ, doi, tgfβil, mice, pathogenic, expression, fig, pubmed, google, scholar, data, analysis, eae, disease, tbet, differentiated, autoimmune, induction, naïve, vitro, induced, ilr, tgfβilinduced, pmc, immunol, cell, genes, induce, days, ilβilil, article, ifnγ, cytokine, transfer, tgfβilil, experiments, nature, differentiation, development, free, mmm, nat, tbx, independent, shown, production, cytokines, tgfβinduced, supplementary,
Topics {✒️}
il-1β-il-6-il-23 differentiating condition il-1β-il-6-il-23-differentiated th17 cells tgf-β-il-6-induced th17 cells 100ng/ml anti-tgf-β3 antibody tgf-β1-il-6-il-23 condition failed il-1β-il-6-induced th17 cells tgf-β3-il-6-induced th17 cells tgf-β3/il-6-induced th17 cells tgf-β1-il-6-induced th17 cells tgf-β1/il-6-induced th17 cells tgf-β3-il-6-induced 2d2 cells il-1β-il-6-il-23 th17 cells il-1β/il-6/il-23 th17 cells tgf-β1/il-6-derived th17 cells il-23r-gfp reporter mice16 tgf-β3-yfp reporter mice tgf-β3/il-6 express gm-csf adding neutralizing anti-tgf-β1 tgf-β1/il-6-differentiated th17 cells conventional pathogen-free facility anti-tgf-β3 neutralizing antibody tgf-β3-induced th17 cells tgf-β3cre-xrosadtr littermate control il-17-ifn-γ double producers tgf-β1-induced th17 cells mog35–55-immunized tgf-β3cre+xrosadtr gm-csf-deficient th17 cells tgf-β1-il-6 develop mild tgf-β3-il-6 condition compared tgf-β3–il-6 th17 cells tgf-β3/il-6 th17 cells tgf-β1-il-6 th17 cells il-23r-deficient th17 cells il-17+ifn-γ+ th17 cells tgf-β1-il-6-il-23 results naïve tgf-β3fl/fl cd4+ t-bet-deficient th17 cells t-bet–deficient th17 cells tgf-β1-il-6-induced plate bound anti-cd3 il-23-dependent tgf-β3 production disrupted ifn-gamma gene quantitative rt-pcr analysis anti-tgf-β3 antibody il-1β-il-6-il-23 il-1β+il-6+il-23 il-1β/il-6/il-23 tgf-β3 overcomes lack tgf-β3-yfp expression quantitative rt-pcr confirmed
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