
NCBI . NLM . NIH . GOV {
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Title[redir]:
The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF - PMC
Description:
Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) require exposure to IL-23 to become encephalitogenic, but the mechanism by which IL-23 promotes their pathogenicity is not known. Here we found that IL-23 induced production of the ...
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Keywords {🔍}
cells, gmcsf, doi, mice, production, expression, fig, eae, pubmed, google, scholar, tgfβ, presence, data, ila, ilβ, stimulation, supplementary, anticd, pmc, cell, wildtype, article, stimulated, splenocytes, cns, produced, ngml, ilr, tbet, csf, immunol, similar, development, rorγt, free, encephalitogenicity, required, μgml, autoimmune, cytokines, tnf, flow, cytokine, role, shown, secretion, effect, conditions, experiments,
Topics {✒️}
granulocyte-macrophage colony-stimulating factor anti-gm-csf-treated group survived th17 cell-derived gm-csf generously providing anti-gm-csf gm-csf-deficient th17 cells il-1/il-1r antagonist system il-23/th17/gm-csf axis anti-gm-csf treatment quantitative real-time pcr il-23/gm-csf amplification loop il-23-induced gm-csf production il-17a−gm-csf+ cells il-17a+gm-csf− cells il-17a+gm-csf+ cells il-17a+gm-csf−cells pmc beta search blocking gm-csf activity tgf-β produce gm-csf abundant gm-csf secretion il-17a−ifn-γ− cells tumor growth factor-β ccr6+gm-csf− th17 cells endogenously produced gm-csf gm-csf-deficient mice th17-driven inflammatory disease cells express gm-csfr transgenic mbpac1-11-specific tcr gm-csf expression correlates regulate gm-csf expression modify gm-csf expression normal gm-csf expression investigated gm-csf production optimal gm-csf production gm-csf-deficient th1 gm-csf-deficient cd4+ naive cd4+cd25−cd62lhicd44lo il-1β upregulates production csf2−/−-mbpac1-11 transgenic mice csf2−/−mbpac1-11 transgenic mice longer-lasting th17 responses increased gm-csf production mbpac1-11-specific wild-type mbp-tcr-csf2−/− mice gm-csfrβ surface expression pathogenic il-23-driven counterparts gm-csf induces il-23 cells expressed gm-csf gm-csf mediates autoimmunity il-17a+gm-csf+ gm-csf+ th17 cells
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Analytics and Tracking {📊}
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