We are analyzing https://link.springer.com/article/10.1186/s13059-017-1336-6.

Title:
Epitranscriptomic influences on development and disease | Genome Biology
Description:
RNA contains over 150 types of chemical modifications. Although many of these chemical modifications were discovered several decades ago, their functions were not immediately apparent. Discoveries of RNA demethylases, along with advances in mass spectrometry and high-throughput sequencing techniques, have caused research into RNA modifications to progress at an accelerated rate. Post-transcriptional RNA modifications make up an epitranscriptome that extensively regulates gene expression and biological processes. Here, we present an overview of recent advances in the field that are shaping our understanding of chemical modifications, their impact on development and disease, and the dynamic mechanisms through which they regulate gene expression.
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Keywords {🔍}

pubmed, article, google, scholar, rna, cas, cell, mrna, central, methylation, translation, modifications, mettl, cells, fto, trna, expression, studies, functions, nature, protein, biol, methyltransferase, transcripts, cancer, nat, wang, alkbh, differentiation, human, complex, roles, promotes, modification, identified, sites, stem, ythdf, demethylation, gene, regulation, liu, nsun, chem, res, nmethyladenosine, shown, nuclear, role, leukemia,

Topics {✒️}

ythdf2-dependent pathway mediates post-transcriptional rna modifications rna post-transcriptional modifications conserved retinoid-independent stabilizer water-soluble diimide cmct carbodiimide metho-p-toluenesulfonate carbon-carbon linked ribonucleoside article download pdf carbon-carbon ribofuranosyl nucleoside transcriptional n6-adenosine methylation il-7-mediated stat5 activation n6-methyladenosine-dependent regulation aml1-eto requires enhanced n6-methyladenosine-modified rna n6-methyladenosine rna demethylase αkg-dependent dioxygenases fto m6a-laic-seq reveals alkbh5-mediated m6a-demethylation n6-methyladenosine binding protein post-transcriptional modifications dynamic n1-methyladenosine methylome mrna n6-adenosine methyltransferase il-7/stat5/socs pathways shape-selective rna recognition transcriptome-wide mapping post-transcriptional regulation detecting rna modifications high-throughput sequencing techniques m6a-modified maternal rnas box snorna/rnp formation meiosis-specific protein meioc ythdc1 yth domain privacy choices/manage cookies perry rp ythdf3 facilitates translation rna epigenetics n1-methyladenosine modification ythdf2 destabilizes m6a mrna cytoplasmic appearance socs family proteins heterogeneous nuclear rna regulates mammalian spermatogenesis heat-shock responsive transcripts rna fate determination heterogeneous nuclear ribonucleoprotein eukaryotic messenger rna full-length trna unusual base pairing neuro-developmental disorders creative commons license

Questions {❓}

Grand challenge commentary: RNA epigenetics?

Schema {🗺️}

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         description:RNA contains over 150 types of chemical modifications. Although many of these chemical modifications were discovered several decades ago, their functions were not immediately apparent. Discoveries of RNA demethylases, along with advances in mass spectrometry and high-throughput sequencing techniques, have caused research into RNA modifications to progress at an accelerated rate. Post-transcriptional RNA modifications make up an epitranscriptome that extensively regulates gene expression and biological processes. Here, we present an overview of recent advances in the field that are shaping our understanding of chemical modifications, their impact on development and disease, and the dynamic mechanisms through which they regulate gene expression.
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