We are analyzing https://link.springer.com/chapter/10.1007/978-3-030-14366-4_5.

Title:
Heterogeneity and Plasticity of Breast Cancer Stem Cells | SpringerLink
Description:
In the last 20 years, the conventional view of breast cancer as a homogeneous collection of highly proliferating malignant cells was totally replaced by a model of increased complexity, which points out that breast carcinomas are tissues composed of multiple...
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Keywords {🔍}

pubmed, google, scholar, article, cancer, cas, breast, cells, cell, central, stem, res, metastasis, epithelialmesenchymal, clin, transition, mammary, heterogeneity, resistance, tumor, human, role, biol, plasticity, nat, epithelial, emt, chapter, matrix, progression, tumour, extracellular, med, paredes, sci, development, carcinoma, mol, nature, pcadherin, ribeiro, malignant, therapeutic, clinical, aldehyde, expression, chemotherapy, natl, rev, oncol,

Topics {✒️}

pelp1/hdac2/mir-200 regulatory network month download article/chapter tendon stem/progenitor cells cd44-targeted docetaxel conjugate �intermediate/metastable” emt state tumorigenic breast-cancer cells weakening cell-cell adhesions matrix-mediated cell behaviour e-cadherin cellular context radiation-induced genomic instability hybrid epithelial/mesenchymal phenotype genome-wide transcript analysis cell-extracellular matrix interactions promote epithelial-mesenchymal transition claudin-low intrinsic subtype epithelial cell-cell adhesion tumour micro-environment heterogeneity cd44+/cd24−/low cells induce epithelial-mesenchymal transition radiation-resistant cells involved mammary alveolar development acid-resistant phenotype individual cell migration high aldehyde dehydrogenase p-cadherin functional role human breast tumors potential therapeutic targets human tumor cells cancer stem cells growth factor receptors privacy choices/manage cookies induce stem cell control stem cells pluripotent stem cells human hepatoma cells human breast carcinoma de sauvage fj chaffer cl device instant download breast cancer cells stem cells heterogeneity stem cell properties enhanced malignant circulating tumor cells small molecule inhibitors breast carcinoma cells metastasis-initiating cells cd44+/cd24− phenotype inflammatory breast cancer breast epithelial cells

Questions {❓}

Alison MR, Lim SM, Nicholson LJ (2011) Cancer stem cells: problems for therapy?
Jolly MK, Mani SA, Levine H (2018) Hybrid epithelial/mesenchymal phenotype(s): the ‘fittest’ for metastasis?

Schema {🗺️}

ScholarlyArticle:
      headline:Heterogeneity and Plasticity of Breast Cancer Stem Cells
      pageEnd:103
      pageStart:83
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-030-14366-4.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Stem Cells Heterogeneity in Cancer
         isbn:
            978-3-030-14366-4
            978-3-030-14365-7
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Bárbara Sousa
            affiliation:
                  name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup)
                  address:
                     name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
                     type:PostalAddress
                  type:Organization
                  name:Institute of Investigation and Innovation in Health (i3S)
                  address:
                     name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ana Sofia Ribeiro
            affiliation:
                  name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup)
                  address:
                     name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
                     type:PostalAddress
                  type:Organization
                  name:Institute of Investigation and Innovation in Health (i3S)
                  address:
                     name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Joana Paredes
            affiliation:
                  name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup)
                  address:
                     name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
                     type:PostalAddress
                  type:Organization
                  name:Institute of Investigation and Innovation in Health (i3S)
                  address:
                     name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
                     type:PostalAddress
                  type:Organization
                  name:Faculty of Medicine of the University of Porto (FMUP)
                  address:
                     name:Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Breast cancer, Stem cells, Breast cancer stem cells (BCSCs), Plasticity, Stemness, EMT (epithelial-to-mesenchymal transition), MET (mesenchymal-to-epithelial transition), Tumour heterogeneity, Biomarkers, Therapy resistance, Metastasis, Tumour microenvironment, ECM (extracellular matrix), Metabolism
      description:In the last 20 years, the conventional view of breast cancer as a homogeneous collection of highly proliferating malignant cells was totally replaced by a model of increased complexity, which points out that breast carcinomas are tissues composed of multiple populations of transformed cells. A large diversity of host cells and structural components of the extracellular matrix constitute the mammary tumour microenvironmentTumour microenvironment, which supports its growth and progression, where individual cancer cells evolve with cumulative phenotypic and genetic heterogeneity. Moreover, contributing to this heterogeneity, it has been demonstrated that breast cancers can exhibit a hierarchical organization composed of tumour cells displaying divergent lineage biomarkers and where, at the apex of this hierarchy, some neoplastic cells are able to self-renew and to aberrantly differentiate. Breast cancer stem cells (BCSCs), as they were entitled, not only drive tumourigenesis, but also mediate metastasis and contribute to therapy resistanceTherapy resistance. Recently, adding more complexity to the system, it has been demonstrated that BCSCs maintain high levels of plasticity, being able to change between mesenchymal-like and epithelial-like states in a process regulated by the tumour microenvironmentTumour microenvironment. These stem cell state transitions play a fundamental role in the process of tumour metastasis, as well as in the resistance to putative therapeutic strategies to target these cells. In this chapter, it will be mainly discussed the emerging knowledge regarding the contribution of BCSCs to tumour heterogeneityTumour heterogeneity, their plasticity, and the role that this plasticity can play in the establishment of distant metastasis. A major focus will also be given to potential clinical implications of these discoveries in breast cancer recurrence and to possible BCSC targeted therapeutics by the use of specific biomarkers.
      datePublished:2019
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Book:
      name:Stem Cells Heterogeneity in Cancer
      isbn:
         978-3-030-14366-4
         978-3-030-14365-7
Organization:
      name:Springer International Publishing
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      name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup)
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         type:PostalAddress
      name:Institute of Investigation and Innovation in Health (i3S)
      address:
         name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
         type:PostalAddress
      name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup)
      address:
         name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
         type:PostalAddress
      name:Institute of Investigation and Innovation in Health (i3S)
      address:
         name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
         type:PostalAddress
      name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup)
      address:
         name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
         type:PostalAddress
      name:Institute of Investigation and Innovation in Health (i3S)
      address:
         name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
         type:PostalAddress
      name:Faculty of Medicine of the University of Porto (FMUP)
      address:
         name:Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
         type:PostalAddress
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Person:
      name:Bárbara Sousa
      affiliation:
            name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup)
            address:
               name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
               type:PostalAddress
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            name:Institute of Investigation and Innovation in Health (i3S)
            address:
               name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
               type:PostalAddress
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      name:Ana Sofia Ribeiro
      affiliation:
            name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup)
            address:
               name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
               type:PostalAddress
            type:Organization
            name:Institute of Investigation and Innovation in Health (i3S)
            address:
               name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
               type:PostalAddress
            type:Organization
      name:Joana Paredes
      affiliation:
            name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup)
            address:
               name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
               type:PostalAddress
            type:Organization
            name:Institute of Investigation and Innovation in Health (i3S)
            address:
               name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
               type:PostalAddress
            type:Organization
            name:Faculty of Medicine of the University of Porto (FMUP)
            address:
               name:Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
               type:PostalAddress
            type:Organization
      email:[email protected]
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      name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
      name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
      name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
      name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
      name:Institute of Pathology and Molecular Immunology of the University of Porto (Ipatimup), Porto, Portugal
      name:Institute of Investigation and Innovation in Health (i3S), Porto, Portugal
      name:Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal
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