
NCBI . NLM . NIH . GOV {
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Title[redir]:
CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells - PMC
Description:
CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with appropriate extracellular matrix ligands promotes the migration and invasion ...
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Keywords {🔍}
cancer, cell, google, scholar, pubmed, cells, doi, pmc, expression, tumor, article, prostate, free, isoforms, metastasis, migration, domain, breast, bone, progression, cdv, matrix, variant, interaction, surface, involved, metastatic, role, bourguignon, angiogenesis, biol, invasion, osteopontin, stem, human, signaling, mmp, endothelial, adhesion, receptor, chellaiah, extracellular, opn, standard, shown, binding, res, cleavage, wang, desai,
Topics {✒️}
functional arginine-glycine-aspartic acid hgf/c-met signaling presenilin-1/γ secretase induced presenilin-1/y-secretase cleavage occurs arginine-glycine-aspartic acid pmc beta search [google scholar] draffin runx2/smad 5/receptor activator psa-free survival modulate migration/invasion processes cd44-mediated tumor invasion lymph node metastasis transcriptional factor runx2 expressing cell lines presenilin-1/y-secretase expressing larger isoforms tumor cell growth cancers including colon intracellular domain/cytoplasmic domain prostate cancer growth orian-rousseau invasive phenotype due sequential proteolytic processing intramembrane site releasing proteins including cd44 receptor-ligand interaction master transcription factor cd44 cleavage induced human endothelial cells rat carcinoma cells make cell lines cd44/mmp9 complex formation neoplastic human prostates cancer stem cell cancer stem cells regulate key proteins bone marrow epithelium publisher site pdf high molecular weight tumor cell surface rat pancreatic carcinoma pmc disclaimer breast cancer cells promote tumor progression endothelial cell function promote cell motility alpha-v-dependent vascular cd44 expression prostate cancer cells hematopoietic stem cells
Questions {❓}
- Are CD44 variant isoforms involved in human tumour progression?
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- How much money does https://scholar.google.com/scholar_lookup?journal=Mol.%20Cancer%20Res.&title=Understanding%20the%20dual%20nature%20of%20CD44%20in%20breast%20cancer%20progression&author=J.%20M.%20Louderbough&author=J.%20A.%20Schroeder&volume=9&publication_year=2011&pages=1573-1586&pmid=21970856&doi=10.1158/1541-7786.MCR-11-0156& make?
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=Oncotarget&title=CD44%20increases%20the%20efficiency%20of%20distant%20metastasis%20of%20breast%20cancer&author=S.%20McFarlane&author=J.%20A.%20Coulter&author=P.%20Tibbits&author=A.%20O'Grady&author=C.%20McFarlane&volume=6&publication_year=2015&pages=11465-11476&pmid=25888636&doi=10.18632/oncotarget.3410& generate?
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- Earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem.&title=Identification%20of%20function%20for%20CD44%20intracytoplasmic%20domain%20(CD44-ICD):%20modulation%20of%20matrix%20metalloproteinase%209%20(MMP-9)%20transcription%20via%20novel%20promoter%20response%20element&author=K.%20E.%20Miletti-Gonz%C3%A1lez&author=K.%20Murphy&author=M.%20N.%20Kumaran&author=A.%20K.%20Ravindranath&author=R.%20P.%20Wernyj&volume=287&publication_year=2012&pages=18995-19007&pmid=22433859&doi=10.1074/jbc.M111.318774&
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- How much profit does https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Biol.&title=Proteolytic%20release%20of%20CD44%20intracellular%20domain%20and%20its%20role%20in%20the%20CD44%20signaling%20pathway&author=I.%20Okamoto&author=Y.%20Kawano&author=D.%20Murakami&author=T.%20Sasayama&author=N.%20Araki&volume=155&publication_year=2001&pages=755-762&pmid=11714729&doi=10.1083/jcb.200108159& generate?
- What's the total monthly financial gain of https://doi.org/10.1038/sj.onc.1202447?
- Earnings of https://scholar.google.com/scholar_lookup?journal=Oncogene&title=CD44%20cleavage%20induced%20by%20a%20membrane-associated%20metalloprotease%20plays%20a%20critical%20role%20in%20tumor%20cell%20migration&author=I.%20Okamoto&author=Y.%20Kawano&author=H.%20Tsuiki&author=J.%20Sasaki&author=M.%20Nakao&volume=18&publication_year=1999&pages=1435-1446&pmid=10050880&doi=10.1038/sj.onc.1202447&
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- Monthly income for https://scholar.google.com/scholar_lookup?journal=Genes%20Dev.&title=CD44%20is%20required%20for%20two%20consecutive%20steps%20in%20HGF/c-Met%20signaling&author=V.%20Orian-Rousseau&author=L.%20Chen&author=J.%20P.%20Sleeman&author=P.%20Herrlich&author=H.%20Ponta&volume=16&publication_year=2002&pages=3074-3086&pmid=12464636&doi=10.1101/gad.242602&
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- How much does https://scholar.google.com/scholar_lookup?journal=Mol.%20Biol.%20Cell&title=Hepatocyte%20growth%20factor-induced%20Ras%20activation%20requires%20ERM%20proteins%20linked%20to%20both%20CD44v6%20and%20F-actin&author=V.%20Orian-Rousseau&author=H.%20Morrison&author=A.%20Matzke&author=T.%20Kastilan&author=G.%20Pace&volume=18&publication_year=2007&pages=76-83&pmid=17065554&doi=10.1091/mbc.E06-08-0674& pull in monthly?
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- https://scholar.google.com/scholar_lookup?journal=Cancer%20Lett.&title=The%20role%20of%20angiogenesis,%20laminin%20and%20CD44%20expression%20in%20metastatic%20behavior%20of%20early-stage%20low-grade%20invasive%20breast%20carcinomas&author=E.%20Ozer&author=T.%20Canda&author=B.%20Kurtodlu&volume=121&publication_year=1997&pages=119-123&pmid=9570348&doi=10.1016/S0304-3835(97)00346-7&'s total income per month
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- How much income does https://scholar.google.com/scholar_lookup?journal=Arch.%20Biochem.%20Biophys.&title=Bone%20tissue%20remodeling%20and%20development:%20focus%20on%20matrix%20metalloproteinase%20functions&author=K.%20B.%20Paiva&author=J.%20M.%20Granjeiro&volume=561&publication_year=2014&pages=74-87&pmid=25157440&doi=10.1016/j.abb.2014.07.034& have?
- What's https://doi.org/10.1002/eji.1830250228's gross income?
- How much does https://scholar.google.com/scholar_lookup?journal=Eur.%20J.%20Immunol.&title=Role%20of%20CD44%20cytoplasmic%20domain%20in%20hyaluronan%20binding&author=A.%20Perschl&author=J.%20Lesley&author=N.%20English&author=I.%20Trowbridge&author=R.%20Hyman&volume=25&publication_year=1995&pages=495-501&pmid=7533087&doi=10.1002/eji.1830250228& gross monthly?
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- What's the income generated by https://doi.org/10.1136/mp.50.2.57 each month?
- How much does https://scholar.google.com/scholar_lookup?journal=Mol.%20Pathol.&title=CD44%20and%20the%20adhesion%20of%20neoplastic%20cells&author=Z.%20Rudzki&author=S.%20Jothy&volume=50&publication_year=1997&pages=57-71&pmid=9231152&doi=10.1136/mp.50.2.57& make?
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- Income figures for https://doi.org/10.1074/jbc.M102273200
- How much does https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem.&title=Differential%20involvement%20of%20the%20hyaluronan%20(HA)%20receptors%20CD44%20and%20receptor%20for%20HA-mediated%20motility%20in%20endothelial%20cell%20function%20and%20angiogenesis&author=R.%20C.%20Savani&author=G.%20Cao&author=P.%20M.%20Pooler&author=A.%20Zaman&author=Z.%20Zhou&volume=276&publication_year=2001&pages=36770-36778&pmid=11448954&doi=10.1074/jbc.M102273200& generate monthly?
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- How much revenue does https://scholar.google.com/scholar_lookup?journal=J.%20Exp.%20Med.&title=Prevention%20of%20tumor%20metastasis%20formation%20by%20anti-variant%20CD44&author=S.%20Seiter&author=R.%20Arch&author=S.%20Reber&author=D.%20Komitowski&author=M.%20Hofmann&volume=177&publication_year=1993&pages=443-455&pmid=8426113&doi=10.1084/jem.177.2.443& bring in?
- Earnings of https://doi.org/10.1136/mp.51.4.191
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Mol.%20Pathol.&title=The%20normal%20structure%20and%20function%20of%20CD44%20and%20its%20role%20in%20neoplasia&author=R.%20J.%20Sneath&author=D.%20C.%20Mangham&volume=51&publication_year=1998&pages=191-200&pmid=9893744&doi=10.1136/mp.51.4.191& each month?
- Financial intake of https://doi.org/10.1002/(SICI)1097-0045(199603)28:3<153::AID-PROS2>3.0.CO;2-G
- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Prostate&title=Expression%20of%20CD44%20isoforms%20in%20human%20prostate%20tumor%20cell%20lines&author=J.%20W.%20Stevens&author=P.%20L.%20Palechek&author=T.%20L.%20Griebling&author=R.%20J.%20Midura&author=O.%20W.%20Rokhlin&volume=28&publication_year=1996&pages=153-161&pmid=8628718&doi=10.1002/(SICI)1097-0045(199603)28:3<153::AID-PROS2>3.0.CO;2-G& have monthly?
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- How much profit is https://scholar.google.com/scholar_lookup?journal=Clin.%20Cancer%20Res.&title=Osteopontin:%20possible%20role%20in%20prostate%20cancer%20progression&author=G.%20N.%20Thalmann&author=R.%20A.%20Sikes&author=R.%20E.%20Devoll&author=J.%20A.%20Kiefer&author=R.%20Markwalder&volume=5&publication_year=1999&pages=2271-2277&pmid=10473115& making per month?
- Profit of https://doi.org/10.1242/jcs.00954
- How much profit is https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Sci.&title=The%20role%20of%20the%20CD44%20transmembrane%20and%20cytoplasmic%20domains%20in%20co-ordinating%20adhesive%20and%20signalling%20events&author=R.%20F.%20Thorne&author=J.%20W.%20Legg&author=C.%20M.%20Isacke&volume=117&issue=Pt%203&publication_year=2004&pages=373-380&pmid=14702383&doi=10.1242/jcs.00954& making per month?
- How much income does https://doi.org/10.1016/j.stem.2014.01.009 have?
- Get to know what's the income of https://scholar.google.com/scholar_lookup?journal=Cell%20Stem%20Cell&title=CD44v6%20is%20a%20marker%20of%20constitutive%20and%20reprogrammed%20cancer%20stem%20cells%20driving%20colon%20cancer%20metastasis&author=M.%20Todaro&author=M.%20Gaggianesi&author=V.%20Catalano&author=A.%20Benfante&author=F.%20Iovino&volume=14&publication_year=2014&pages=342-356&pmid=24607406&doi=10.1016/j.stem.2014.01.009&
- What are the earnings of https://doi.org/10.1002/(SICI)1097-0215(19960529)66:5<664::AID-IJC14>3.0.CO;2-4?
- How much money does https://scholar.google.com/scholar_lookup?journal=Int.%20J.%20Cancer&title=Evidence%20of%20involvement%20of%20CD44%20in%20endothelial%20cell%20proliferation,%20migration%20and%20angiogenesis%20in%20vitro&author=V.%20Trochon&author=C.%20Mabilat&author=P.%20Bertrand&author=Y.%20Legrand&author=F.%20Smadja-Joffe&volume=66&publication_year=1996&pages=664-668&pmid=8647630&doi=10.1002/(SICI)1097-0215(19960529)66:5<664::AID-IJC14>3.0.CO;2-4& make?
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- What's the income of https://scholar.google.com/scholar_lookup?journal=J.%20Cell.%20Biochem.&title=Osteopontin%20overexpression%20in%20breast%20cancer:%20knowledge%20gained%20and%20possible%20implications%20for%20clinical%20management&author=A.%20B.%20Tuck&author=A.%20F.%20Chambers&author=A.%20L.%20Allan&volume=102&publication_year=2007&pages=859-868&pmid=17721886&doi=10.1002/jcb.21520&?
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- What's the income of https://scholar.google.com/scholar_lookup?journal=Arch.%20Otolaryngol.%20Head%20Neck%20Surg.&title=Hyaluronan%20and%20the%20interaction%20between%20CD44%20and%20epidermal%20growth%20factor%20receptor%20in%20oncogenic%20signaling%20and%20chemotherapy%20resistance%20in%20head%20and%20neck%20cancer&author=S.%20J.%20Wang&author=L.%20Y.%20Bourguignon&volume=132&publication_year=2006a&pages=771-778&pmid=16847188&doi=10.1001/archotol.132.7.771&?
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- https://doi.org/10.1002/hed.20544 income
- What's the income of https://scholar.google.com/scholar_lookup?journal=Head%20Neck&title=Association%20of%20CD44%20V3-containing%20isoforms%20with%20tumor%20cell%20growth,%20migration,%20matrix%20metalloproteinase%20expression,%20and%20lymph%20node%20metastasis%20in%20head%20and%20neck%20cancer&author=S.%20J.%20Wang&author=V.%20B.%20Wreesmann&author=L.%20Y.%20Bourguignon&volume=29&publication_year=2007&pages=550-558&pmid=17252589&doi=10.1002/hed.20544&?
- Check the income stats for https://doi.org/10.1158/1535-7163.MCT-12-0895
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- Income figures for https://doi.org/10.1126/science.271.5248.509
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Science&title=Receptor-ligand%20interaction%20between%20CD44%20and%20osteopontin%20(Eta-1)&author=G.%20F.%20Weber&author=S.%20Ashkar&author=M.%20J.%20Glimcher&author=H.%20Cantor&volume=271&publication_year=1996&pages=509-512&pmid=8560266&doi=10.1126/science.271.5248.509& generate?
- Financial intake of https://doi.org/10.1177/1535370213480714
- Profit of https://scholar.google.com/scholar_lookup?journal=Exp.%20Biol.%20Med.&title=CD44%20integrates%20signaling%20in%20normal%20stem%20cell,%20cancer%20stem%20cell%20and%20(pre)metastatic%20niches&author=K.%20Williams&author=K.%20Motiani&author=P.%20V.%20Giridhar&author=S.%20Kasper&volume=238&publication_year=2013&pages=324-338&pmid=23598979&doi=10.1177/1535370213480714&
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- How much does https://scholar.google.com/scholar_lookup?journal=J.%20Invest.%20Dermatol.&title=Characterization%20of%20expression%20and%20modulation%20of%20cell%20adhesion%20molecules%20on%20an%20immortalized%20human%20dermal%20microvascular%20endothelial%20cell%20line%20(HMEC-1)&author=Y.%20Xu&author=R.%20A.%20Swerlick&author=N.%20Sepp&author=D.%20Bosse&author=E.%20W.%20Ades&volume=102&publication_year=1994&pages=833-837&pmid=7516395&doi=10.1111/1523-1747.ep12382086& generate monthly?
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- How profitable is https://scholar.google.com/scholar_lookup?journal=Oncology&title=Soluble%20CD44%20variant%206%20as%20a%20prognostic%20indicator%20in%20patients%20with%20colorectal%20cancer&author=N.%20Yamane&author=S.%20Tsujitani&author=M.%20Makino&author=M.%20Maeta&author=N.%20Kaibara&volume=56&publication_year=1999&pages=232-238&pmid=10202279&doi=10.1159/000011970&?
- How much does https://doi.org/10.1101/gad.13.1.35 make?
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Genes%20Dev.&title=Localization%20of%20matrix%20metalloproteinase%209%20to%20the%20cell%20surface%20provides%20a%20mechanism%20for%20CD44-mediated%20tumor%20invasion&author=Q.%20Yu&author=I.%20Stamenkovic&volume=13&publication_year=1999&pages=35-48&pmid=9887098&doi=10.1101/gad.13.1.35&?
- See how much https://doi.org/10.1038/onc.2012.611 makes per month
- Revenue of https://scholar.google.com/scholar_lookup?journal=Oncogene&title=Stem%20cell%20CD44v%20isoforms%20promote%20intestinal%20cancer%20formation%20in%20Apc(min)%20mice%20downstream%20of%20Wnt%20signaling&author=J.%20Zeilstra&author=S.%20P.%20Joosten&author=H.%20van%20Andel&author=C.%20Tolg&author=A.%20Berns&volume=33&publication_year=2014&pages=665-670&pmid=23318432&doi=10.1038/onc.2012.611&
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- Income figures for https://www.nih.gov/
- Check the income stats for https://www.hhs.gov/
- https://www.usa.gov/ income
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