
NCBI . NLM . NIH . GOV {
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Title[redir]:
CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis - PMC
Description:
A subpopulation (CD44+/CD24-) of breast cancer cells has been reported to have stem/progenitor cell properties. The aim of this study was to investigate whether this subpopulation of cancer cells has the unique ability to invade, home, and ...
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Keywords {🔍}
cells, cancer, cell, cdcd, doi, metastasis, breast, lines, expression, pubmed, google, scholar, mdamb, genes, tmd, subpopulation, invasion, phenotype, lung, invasive, bone, human, figure, line, shown, properties, signature, studies, growth, metastatic, res, sites, luminal, levels, stem, analysis, injected, lmd, expressed, proinvasive, mice, higher, receptor, cxcr, animals, pmc, flow, cytometry, hst, gene,
Topics {✒️}
er-α-negative cell lines stromal cell-derived factor-1α discussion cd44+/cd24- phenotype cd44+/cd24--positive cell lines transforming growth factor-β1 er-α-negative cells connective tissue-derived factor pmc beta search cd44+/cd24- population plays cd44-mediated oncogenic signaling high-resolution faxitron images parathyroid hormone-related peptide parathyroid hormone-related protein carcinoma-derived cell lines female nu/nu mice tumorigenic stem/progenitor cells stem/progenitor cell properties cell-cell communication genes erbb2-positive breast cancers er-α negative cd44+/cd24- phenotype correlates nf-kappab activation er-α expression pattern cd44+/cd24- phenotype possess cd44+/cd24- cells confers competing interests osteosclerotic bone metastasis culture cd44-/cd24- subpopulation increased cd44+/cd24- subpopulation variable cd44+/cd24- subpopulation license information pmcid similar cd44+/cd24- subpopulations cd44+/cd24- cancer cells cell lines mda-mb-231 cd44+/cd24+ cells exhibited significant cd44+/cd24- population mcf10a cell progenitor enhanced tumorigenic potential er-α-positive cd44+/cd24-/low cells mda-mb-468 cells contributed luminal/erbb2+ sk-br-3 cancer cell migration epidermal growth factor human epithelial cells human breast cancer stem/progenitor phenotype defined rt-pcr results stem/progenitor cells defined express higher levels
Questions {❓}
- Will cancer stem cells provide new therapeutic targets?
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