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Title[redir]:
The Ets transcription factor Elf5 specifies mammary alveolar cell fate - PMC
Description:
Hormonal cues regulate mammary development, but the consequent transcriptional changes and cell fate decisions are largely undefined. We show that knockout of the prolactin-regulated Ets transcription factor Elf5 prevented formation of the secretory ...
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Keywords {🔍}
elf, mammary, mice, expression, doi, cell, fig, cells, alveolar, luminal, dpc, dox, progenitor, glands, epithelium, wildtype, pubmed, google, scholar, differentiation, control, bars, development, virgin, gata, transplants, pregnancy, gland, observed, milk, collected, treated, transcription, compared, βcasein, doxtreated, mrna, fate, asselinlabat, protein, population, animals, forced, tebs, secretory, ductal, black, white, wkold, treatment,
Topics {✒️}
teton–elf5–ires–egfp construct ets-related transcription factors taqman probe-based system prolactin-driven epithelial proliferation predominantly estrogen receptor-negative lin−cd24+cd29lo cells elf5–ires–egfp construct pmc beta search dimensional colony-forming assays anti-cd45 antibodies conjugated α-total p44/42 mapk ets transcription factor untreated elf5elf5/+/mtb/+ mice marie-liesse asselin-labat 3 α-phosphorylated p44/42 mapk elf5-deficient mammary glands elf5tg+/+/mtb/+ mice treated publisher site pdf wild-type mammary transplants elf5tgelf5/+/mtb/+ bitransgenic mice gata3-deficient mammary glands luminal cell fate cell fate specification transcription factor cebpβ dox-treated tg mice cell fate decisions dox-treated tg animals dox-treated wild-type epithelial populations isolated luminal progenitor cells cd61+ luminal progenitor transplants successfully engrafted medical research council transcription factor elf5 dox-treated control animals elf5-expressing cells shared hormonal cues mature luminal population secretory alveolar cells sustained elf5 expression functional mammary gland anti-cd24 conjugated luminal alveolar lineage mammary-gland morphogenesis wild-type rag1−/− hosts putative alveolar progenitor colony formation capacity affected elf5+/− animals progenitor cell hierarchy progenitor cell activity
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