
NCBI . NLM . NIH . GOV {
}
Title[redir]:
The Role of Breast Cancer Stem Cells in Metastasis and Therapeutic Implications - PMC
Description:
Cancer stem cells (CSCs) possess the capacity to self-renew and to generate heterogeneous lineages of cancer cells that comprise tumors. A substantial body of evidence supports a model in which CSCs play a major role in the initiation, maintenance, ...
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Keywords {๐}
cancer, doi, cells, breast, pubmed, google, scholar, cell, stem, cscs, metastasis, tumor, metastatic, pmc, expression, article, free, tumors, human, mammary, phenotype, csc, res, aldh, metastases, pestell, invasion, signaling, liu, role, mice, lines, activity, growth, nfฮบb, dach, cyclin, cdcd, increased, tumorigenic, niche, signals, wang, biol, population, cdcdlow, wicha, gene, evidence, patients,
Topics {โ๏ธ}
cell-surface markers cd44+/cd24โ/low/esa+ cd44+/cd24โ/low cells isolated cd44+/cd24โ/low tumor cells her2/neu-induced mammary tumors stromal cell-derived factor-1 cd44+/cd24โ/low/lineageโ cells notch1-induced mammary tumorigenesis epithelial-mesenchymal transition markers mmtv-wnt1 mammary tumors sorted cd44+/cd24โ/low stem/progenitor cell properties cd44-expressing tumor cells ankyrin-regulated multidrug efflux cd44+/cd24โ/low cells 1 cd44+/cd24โ/low cells drive epithelial-mesenchymal transition urokinase-type plasminogen activator canonical nf-ฮบb pathway pmc beta search cd44+/cd24โ/low phenotype cd44โ/cd24โ/low populations early progenitor/stem cells hyaluronan-mediated cd44 activation nf-kappa b2/p52 lymph node metastasis aldh-overexpressing cancer cells cell-fate determination e-cadherin repressors zeb1 crucial multi-tasking components pmc copyright notice nf-ฮบb involves activation stem cell factor cd44+/cd24โ/low subpopulation cancer stem-cell hypothesis mir-10b inhibits metastasis eradicate csc-driven metastases instituto politรฉcnico nacional acute myeloid leukemia nf-ฮบb activation reduced unique invasion/metastasis properties abc transporter mdr1/abcb1 tumorigenic breast-cancer cells epithelial-mesenchymal transition cd44+/cd24โ/aldh+ phenotype retinal determination gene cyclin d1-dependent basal/mesenchymal phenotype enhanced invasive properties axillary lymph nodes inhibits cyclin d1
Questions {โ}
- Are CSCs the Source of Metastatic Lesions in Breast Cancer?
- How To Eradicate CSC-Driven Metastases?
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