We are analyzing https://link.springer.com/article/10.1007/s10555-024-10213-7.

Title:
CAR T cells in solid tumors and metastasis: paving the way forward | Cancer and Metastasis Reviews
Description:
CAR T cell therapy, hailed as a breakthrough in cancer treatment due to its remarkable outcomes in hematological malignancies, encounters significant hurdles when applied to solid tumors. While notable responses to CAR T cells remain sporadic in these patients, challenges persist due to issues such as on-target off-tumor toxicity, difficulties in their trafficking and infiltration into the tumor, and the presence of a hostile and immunosuppressive microenvironment. This review aims to explore recent endeavors aimed at overcoming these obstacles in CAR T cell therapy for solid tumors. Specifically, we will delve into promising strategies for enhancing tumor specificity through antigen targeting, addressing tumor heterogeneity, overcoming physical barriers, and counteracting the immune-suppressive microenvironment.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, cells, central, car, cell, journal, antigen, therapy, nature, immunotherapy, tumor, chimeric, research, httpsdoiorgs, tumors, cart, medicine, receptor, solid, targeting, immunology, clinical, efficacy, metastasis, wang, tcell, molecular, engineered, science, american, lee, antitumor, httpsdoiorgjitc, microenvironment, expression, gene, target, translational, enhances, park, oncology, society, promotes, function, casucci,

Topics {✒️}

deletion-derived tumour-specific neoantigens anti-pd-1 agent pembrolizumab tgfβ-il-2/15 switch receptor targeting glycosylated pd-l1 month download article/chapter chimeric antigen receptor-engineered regulatory t-cell inhibition combinatorial antigen-sensing circuits complex n-glycan number immune-related adverse effects minimized endothelial cross-reactivity t-bethigh foxo1low effectors cd8+ t-cell recruitment antigen-specific tumour protection disrupting n-glycan expression chimeric antigen receptor car t-cell entry crispr-cas tools anti-gd2 synergizes car t-cell activity armored car t-cells car t-cell therapy induces adaptive resistance affinity-tuned erbb2 full article pdf tumor-infiltrating myeloid cells 4–1bb costimulation ameliorates anti-tumor efficacy tumor-redirected cytotoxic chimeric antigen receptors t-cell cancer immunotherapy anti-cea car tumour-infiltrating stem immunosuppressive solid-tumor microenvironment antigen-independent macrophage response maintaining long-term responses enhances effector functions pd-1 promotes accumulation superior antigen sensitivity combinatorial antigen recognition target pancreatic tumors augments adoptive immunotherapy naive/stem memory patient-derived organoids targeting vegf/vegfr monica casucci eliminate heterogeneous tumors laura de rossi cancer metastasis access mediates immune exclusion

Questions {❓}

Time 2EVOLVE: Predicting efficacy of engineered T-cells - how far is the bench from the bedside?
To go or not to go?

Schema {🗺️}

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