
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Expression of Inducible Factors Reprograms CAR-T Cells for Enhanced Function and Safety - PMC
Description:
Despite the success of CAR-T cell cancer immunotherapy, challenges in efficacy and safety remain. Investigators have begun to enhance CAR-T cells with expression of accessory molecules to address these challenges. Current systems rely on ...
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Keywords {🔍}
cells, cell, figure, expression, cart, car, univect, table, pasp, cat, google, scholar, doi, inducible, human, pubmed, pmc, tcr, article, free, lentiviral, constitutive, antigen, egfp, mice, system, control, vivo, line, itoci, engineered, expansion, primary, cancer, manuscript, construct, data, tumor, receptor, signaling, architecture, antibody, receptors, university, samples, activity, blood, reporter, compared, experiments,
Topics {✒️}
anti-hil6rα scfv-fc-myc tag organisms/strains nod/scid/il2rg log-rank mantel-cox test constitutive egfp-2a-her2-41bb car tandem mini-gene constructs anti-human cd8− apc-h7 anti-hil6rα scfv-fc tcr-modified t-cells engineered ifoxo1−3a+cher2−41bb car tocilizumab-based scfv-fc anti-human cd45-pe uni-vect cell-based system neoantigen-specific tcr-expressing cells chimeric antigen receptor–modified human cd8α/β heterodimer t-cell receptor mimic anti-cd3/cd28 dynabeads sf2 nihms1912467-supplement-sf2 sf3 nihms1912467-supplement-sf3 sf4 nihms1912467-supplement-sf4 sf6 nihms1912467-supplement-sf6 sf5 nihms1912467-supplement-sf5 sf7 nihms1912467-supplement-sf7 03d anti-biotin microbeads sec24a p469l-specific tcrs pasp90 uni-vect/mcherry constructs anti-il-6 receptor antibody cg-prkdcscid il2rgtm1wjl tg combine nfat-driven expression crispr/cas9 method compatible enhancing anti-tumor activity il-6rα blocking antibody t-cell receptor knockout genome-wide crispr screens quanti-luc detection reagent coordinate dual-gene transgenesis acute lymphoblastic leukaemia cell-based reporter assay refractory b-cell lymphomas cancer cell summary constitutive her2–41bb car uni-vect expression cassettes pmc beta search induce antigen-dependent expression biotin conjugated anti-cd3 cell-based assay system gfp permits visualization inducible nfat-driven expression xl1-blue supercompetent cells anti-sense orientation relative
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