NCBI . NLM . NIH . GOV {
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Title[redir]:
CAR T cells targeting solid tumors: carcinoembryonic antigen (CEA) proves to be a safe target - PMC
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Keywords {🔍}
car, cells, cell, cea, cancer, patients, pmc, nct, doi, nlm, targeting, antigen, anticea, ncbi, search, article, transient, infusion, scfv, days, serum, trial, carcinoembryonic, clinical, efficacy, toxicity, trials, treatment, systemic, administration, therapy, cohort, dose, doses, severe, activation, respiratory, engineered, metastatic, metastases, preconditioning, flu, total, healthy, luminal, tcr, free, pubmed, google, scholar,
Topics {✒️}
bw431/26 scfv-igg4 hinge-cd28–cd3ζ mn14 scfv-cd8hinge-cd28–cd3ζ optimal pre-conditioning regimen chimeric antigen receptor inducing auto-immune toxicity pmc beta search distal n-a1 domain generation cd28–cd3ζ car cd28–cd3ζ car trial membrane-proximal cea epitope cancer immunol immunother γ-retrovirus patient cohorts productive anti-tumor response publisher site pdf recent anti-cea car distal epitope independently mfe23 scfv-cd3ζ ethical standards conflict serum ifn-γ median age 58 years median age 48 years metastatic colorectal cancer license information pmcid metastatic colorectal cancers inducing lasting remissions clin cancer res cancer cell membrane systemic il-2 support generation cd3ζ car anti-tumor responses cd3ζ car trial generation carcinoembryonic antigen united states government decreased tumor progression requiring artificial respiration monitor tumor load respiratory toxicity hepatic artery infusion lung capillaries immediately adoptive therapy trials high il-2 doses therapy targeting cea extracellular cea moiety cea levels declined car molecules required lesion remains small clinically relevant inflammation side effects versus severe adverse events entire cell surface
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