
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Enhancing the potency and specificity of engineered T cells for cancer treatment - PMC
Description:
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells has produced tumor responses even in patients with refractory diseases. However, the paucity of antigens that are tumor selective has resulted, on occasion, in “on-target, ...
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Keywords {🔍}
cells, tumor, doi, cell, smartcells, pubmed, google, scholar, car, psca, figure, tgfβ, transgenic, day, antigen, pmc, panel, expression, cancer, signal, article, free, tbbr, icr, receptors, pancreatic, cytokine, signaling, capan, representative, genes, journal, data, profile, expansion, gene, chimeric, receptor, activation, supplementary, research, signals, therapy, expressing, site, analysis, modified, pdf, target, function,
Topics {✒️}
anti-human il4rα-apc antibody tgfβ-ires-δcd19 retroviral constructs pmc beta search cg-prkdcscid il2rgtm1wjl/ szj tgf-beta-mediated regulation gamma c-dependent cytokines enhanced anti-tumor effect psca+tgfβ+il4 expressing tumors cd4/cd25/foxp3 staining tgf-beta superfamily signaling combinatorial antigen-sensing circuits 4-1bb cross-linking enhances tumor-specific molecular-pattern activated ccl4-induced liver fibrosis rat anti-mouse apc anti-human tgfβrii antibody vector expressing ires-gfp optimal anti-tumor effects superior anti-tumor activity cancer discov abstract pancreatic tumor-specific signature capan-1 psca/il4/tgfβ cells 2 mmol/l-glutamax supplemented retained enabling smart-cells tcr-ζ chain signaling chimeric antigen receptor-modified promote anti-tumor effects diminished long-term potency rechallenge induced smart-cell resting human primary anti-tumor responses determined graphs representing total tumor-derived input signals log-transformed normalized data tumor-specific molecular signature smart-cells exhibit selective smart-cells remain selective il4 cytokine-ires-morange smart-cells maintain cd4+ tumor-free animals 5×106 capan1 psca+tgfβ+il4 il4 unlike smart-cells acute lymphoblastic leukemia capan-1 psca/il4/tgfβ 5×106 capan-1 psca/tgfβ/il4 capan-1 psca+tgfβ+il4+ generate retroviral supernatant regulated t-cells smart-cell signal detected measuring foxp3 expression
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