
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Targeting the activated microenvironment with endosialin (CD248)-directed CAR-T cells ablates perivascular cells to impair tumor growth and metastasis - PMC
Description:
Targeting of solid cancers with chimeric antigen receptor (CAR)-T cells is limited by the lack of suitable tumor-specific antigens and the immunosuppressive, desmoplastic tumor microenvironment that impedes CAR-T cell infiltration, activity and ...
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Keywords {🔍}
cells, cart, tumor, cell, mice, endosialin, figure, doi, google, scholar, pubmed, cancer, mouse, supplemental, online, pmc, tumors, human, article, car, panel, free, cbl, balbc, expression, valuessem, metastatic, targeting, growth, tumorbearing, data, treated, target, normal, breast, analysis, day, activity, cdwt, observed, fvbn, lung, blood, days, stroma, stromal, study, representative, sacrificed, models,
Topics {✒️}
n-terminal c-type lectin single-cell multi-omics analysis formalin-fixed paraffin-embedded data availability statements refractory high-risk neuroblastoma pmc beta search transforming growth factor-β upregulating caf-derived versican similar cd4-heavy cd4 dana-faber cancer institute single-cell rna sequencing anti-endosialin mab 3k2l 8 days post-act revealed ifn-gamma-producing lymphocytes pmc copyright notice high-level transgene expression suitable tumor-specific antigens pi3k pathway-independent mechanisms scrna-seq data sets tnf-alpha-producing macrophages pancreatic ductal adenocarcinoma gd2-cart01 neuroblastoma trial tumor-cell marker hmga2 c-type lectin tailed unpaired t-test 5 gy x-irradiation leads recent gd2-cart01 trial cd248wt tumor-bearing mice cell-treated cd248wt mice 4t1-tumor bearing mice tumor necrosis factor-α lewis lung carcinoma hrm1 tumor-bearing mice e-stained lung sections circulating combined hcd34+cd4+ promote tumour aggressiveness vivo 5–7 days post-act tumor-bearing cd248ko mice body x-irradiation body x-irradiation sacrificed 9 days post-act tumor-bearing mice compared chimeric antigen receptor 4t1 tumor-bearing balb/ online supplemental methods modified eagle medium 5 n-terminal domains supplementary materials included human blood donors primary tumor site
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