
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Removal of N-linked glycosylation enhances PD-L1 detection and predicts anti-PD-1/PD-L1 therapeutic efficacy - PMC
Description:
Reactivation of T cell immunity by PD-1/PD-L1 immune checkpoint blockade has been shown to be a promising cancer therapeutic strategy. However, PD-L1 immunohistochemical readout is inconsistent with patient response, which presents a clinical ...
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Keywords {🔍}
pdl, deglycosylation, cells, cancer, cell, patients, figure, pngase, doi, lung, detection, pubmed, google, scholar, hscore, ihc, immune, samples, glycosylation, therapy, pmc, staining, antibody, patient, clinical, tumor, tps, article, expression, sample, tissue, group, free, versus, antipdl, figures, cases, antipdpdl, results, pfs, times, nlinked, response, human, processed, incubated, method, intensity, immunotherapy, treatment,
Topics {✒️}
guiding anti-pd-1/pd-l1 therapy guide anti-pd-1/pd-l1 therapy anti-pd-1/pd-l1 therapy outcomes received anti-pd-1/pd-l1 therapy undergoing anti-pd-1/pd-l1 immunotherapy anti-pd-1/pd-l1 therapy utilized formalin-fixed paraffin-embedded anti-pd-1/pd-l1 antibodies anti-pd-l1 antibody transformed anti-pd-l1 antibody mpdl3280a false-negative pd-l1 detection anti-pd-l1 signal detected anti-pd-l1 signal intensity pd-l1 n-linked glycosylation anti-rabbit secondary antibody pd-l1 h-score readout anti-pd-l1 signal anti-pd-l1 antibody anti-pd-ll antibody anti-pd-l1 therapy pd-l1-negative tumors respond n-linked glycosylation enhances anti-pd-l1 signals aqua-mount mounting medium patient progression-free survival increasing pd-l1-positive cells received anti-pd-1 therapy pd-l1 primary antibodies anti-pd-l1 antibodies pd-l1 correlated significantly increased pd-l1 signal pd-l1 diagnostic antibody pd-l1 protein expression anti-pd-l1 mab pd-l1-positive signal multi-investigator research awards prevent false-negative readouts pd-l1 increased significantly n-linked protein glycosylation scoring pd-l1 tps pd-l1 expression level pd-l1 deglycosylation enhances targeting glycosylated pd-l1 pmc beta search enzyme-linked immunosorbent assay pd-l1 varied significantly pd-l1 critically affects multi-organ cancer tma received pd-l1 inhibitors antibody-based detection sensitivity
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