
NCBI . NLM . NIH . GOV {
}
Title[redir]:
CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors - PMC
Description:
Chimeric antigen receptor (CAR) T-cell therapy targeting solid tumors has stagnated as a result of tumor heterogeneity, immunosuppressive microenvironments, and inadequate intratumoral T cell trafficking and persistence. Early (≤3 days) intratumoral ...
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Keywords {🔍}
cells, tumor, car, doi, tcell, fig, tumors, pubmed, cell, google, scholar, mice, pmc, article, carr, days, free, cancer, intratumoral, radiation, expression, gbm, human, therapy, trafficking, data, transfer, day, model, antitumor, survival, migration, test, solid, treatment, caregfp, study, performed, supplementary, groups, results, scientific, persistence, models, gene, rcar, signals, antigen, mouse, blood,
Topics {✒️}
gro-gene-product/melanoma-growth-stimulating-activity-related factors ny-eso-1–reactive t-cell receptor goat anti-rabbit igg-hrp anti-cd3/anti-cd28 dynabeads rabbit anti-human pd1 car-r2 t-cell groups anti-cd3/cd28 dynabeads chimeric antigen receptor–modified mod-70car t-cell exhaustion rabbit anti-human granzyme enhancing t-cell trafficking chronic t-cell stimulation limiting t-cell infiltration14 rat anti-human cd45 vector-transduced t-cell groups inadequate t-cell migration lipopolysaccharide-induced inflammatory exudate enhancing t-cell chemotaxis rabbit anti-human il-8 cd8+ t-cell death track t-cell migration car t-cell therapy11 car t-cell attractor car t-cell therapy cells remained tumor-free cg-b2mtm1uncprkdcscid il2rgtm1wjl/szj cg-rag1tm1mom il2rgtm1wjl/szj competing interests her2-overexpressing breast cancer t-cell tumor trafficking activates epithelial-mesenchymal transition28 intratumoral t-cell phenotype pmc beta search car t-cell migration il-8 receptor-expressing car car t-cell transfer plenti-cmv-puro-luc 150 mg/kg d-luciferin t-cell phenotypical analysis t-cell proliferation assay dual-color bioluminescence imaging methods cell lines chemokine-mediated immune inhibition cell treated groups show supplementary information files car t-cell treatment luciferase-based killing assay cell-mediated antitumor responses car t-cell proliferation car t-cell production
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