DOI . ORG {
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Title[redir]:
Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an | ITT
Description:
Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an Attack on Tumor Stroma
Title[redir]:
Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an | ITT
Description:
Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an Attack on Tumor Stroma
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Keywords {🔍}
cells, cell, cart, cancer, tumor, fap, tme, activation, tumors, targeting, therapy, expression, fibroblasts, target, fibroblast, expressed, antigen, receptor, solid, treatment, car, cafs, protein, stromal, mice, clinical, antitumor, growth, human, proliferation, efficacy, domain, activity, toxicity, immunotherapy, chimeric, immune, signaling, recognition, therapies, breast, res, heterogeneity, antigens, shown, lung, mol, cancerassociated, microenvironment, studies,
Topics {✒️}
fak-c-src-jak2 pathway anti-fap-f19-δcd28/cd3ζ-car anti-fap-f19-δcd28/cd3ζ fibroblast activation protein-alpha f19 fap-car-t-cells t-bethigh foxo1low effectors fibroblast activation protein-specific human t-lymphocyte cytotoxicity average micro-vessel density anti-fap-kir-based car platelet-derived growth factor tumor necrosis factor-α superior anti-tumor activity fap-targeting fourth-generation car including fast-track processing universal cytokine-mediated killing dove medical press potent t-cell immunotherapy 44 tgf-β-mediated mechanisms antigen peptide-mhc complex intra-tumoral heterogeneity refers single-chain fragment variable castrate-resistant prostate cancer prostate-specific membrane antigen measured micro-vessel density enhancing t-cell proliferation advanced solid tumors triple-negative breast cancer cell receptor-zeta chain cell-mediated tumor eradication weak anti-tumor effect anti-fap targeting moiety systemically delivered car superior killing capacity myeloid-derived suppressor cells affinity enhanced autologous cells targeting mage-a3 t-cell cancer immunotherapy preventing t-cell anergy exclusive tumor-specific antigens org/ensg00000078098-fap/pathology fully immune-competent mice fap-positive mesothelioma cells kte-c19 axicabtagene ciloleucel 14g2a-ox40-ζ constructs showed anti-tumor activity fibroblast activation protein inter-tumoral heterogeneity exists robust anti-tumor response enhanced anti-tumor effect
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