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Myeloid-derived suppressor cells coming of age | Nature Immunology
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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of genomic and biochemical features, and can, on the basis of recent findings, be distinguished by specific surface molecules. The salient feature of these cells is their ability to inhibit T cell function and thus contribute to the pathogenesis of various diseases. In this Review, we discuss the origin and nature of these cells; their distinctive features; and their biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy. Gabrilovich and colleagues review the origin and nature of myeloid-derived suppressor cells, as well as their distinctive features and biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy.
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nature portfolio journals permissions reprints nature portfolio privacy policy cd33+/hla-dr+/โ cells cxcl2/mif-cxcr2 signaling promotes advertising cd11b+ gr-1low cells myeloid-derived suppressor cells myeloid-derived suppressor activity tgf-ฮฒ/ฮฒ-catenin pathway social media tlr2/pi3k/akt/stat3 signaling mycobacteria-induced gr-1+ subsets modulate t-cell responses granulocyte-macrophage colony-stimulating factor trail-r-mediated apoptosis low-dose dexamethasone treatment reduced l-arginine level maintaining feto-maternal immunotolerance anti-pd-l1 efficacy nature nature+ nature 514 nature 543 michela peregoย &ย dmitry gabrilovich myeloid-derived suppressor facilitate maternal-fetal tolerance kinase-regulated interactomes defines castration-resistant prostate cancer regulate collagen-induced arthritis myeloid suppressor cells immune-stimulatory gene therapy cd33+/hla-drneg ccaat/enhancer-binding proteins refractory/relapsed multiple myeloma agonistic trail-r2 antibody stat1-regulated lung mdsc akt/mtor license monocytes author correspondence reactive oxygen species personal data ifn-ฮณr/irf-1 feto-maternal tolerance inducing er stress resected high-risk melanoma tumor-induced tolerance lupus-prone mice linked myeloid development pathologic conditions ranging
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