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  2. Matching Content Categories
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We are analyzing https://link.springer.com/article/10.1007/s00262-014-1646-4.

Title:
Tumor-induced CD14+HLA-DRāˆ’/low myeloid-derived suppressor cells correlate with tumor progression and outcome of therapy in multiple myeloma patients | Cancer Immunology, Immunotherapy
Description:
Myeloid-derived suppressor cells (MDSCs) are heterogeneous, immature, myeloid progenitor cells, which suppress immune responses against tumors. CD14+HLA-DRāˆ’/low monocytic MDSCs (M-MDSC) are increased in patients suffering from multiple myeloma (MM). However, the frequency and function of M-MDSCs with the relationship between the tumor development and outcome of therapy in MM remain unclear. In this study, we analyzed the changes in M-MDSCs in newly diagnosed, relapsed and remission MM patients. In addition, we also assessed the response of M-MDSCs in MM patients treated with a bortezomib-based therapy as well as the impact of bortezomib on the modulation of M-MDSCs in vitro. The levels of M-MDSCs in newly diagnosed and relapsed MM patients were significantly increased compared with those in remission MM patients and healthy donors. Moreover, the levels of M-MDSCs were shown to correlate with tumor progression. The decrease in M-MDSCs after proteasome inhibitory therapy suggested that M-MDSCs could be considered as an indicator for the efficacy of therapy. Finally, we found the plasma from newly diagnosed MM patients, and MM cells were able to induce the accumulation of M-MDSCs in vitro. These results indicated that M-MDSCs could be considered as a prognostic predictor and an important cell type contributing to immune suppressive microenvironment in MM patients. Treatments targeting for M-MDSCs may improve therapeutic outcomes for MM patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Science
  • Health & Fitness
  • Education

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {šŸ’ø}

We're unsure if the website is profiting.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {šŸ”}

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Topics {āœ’ļø}

cd14+hla-drāˆ’/low monocytic mdscs myeloid-derived suppressor cells cd14+ hla-dr- cells myeloid-derived suppressor cell month download article/chapter immunosuppressive cd14+ hla-dr hovon-65/gmmg-hd4 trial myeloid progenitor cells hormone-resistant prostate cancer cell tolerance induced immature myeloid cells membrane-bound tgf-beta 1 anti-cancer agents lenalidomide article cancer immunology full article pdf ostrand-rosenberg immune suppressive microenvironment cells correlate circulating mdsc correlate costa-nunes cm metastatic tumor burden hla-dr schmidt-wolf ig multiple myeloma microenvironment privacy choices/manage cookies inhibiting antitumor immunity squamous cell carcinoma pre-culture rel rodriguez pc international staging system manjili mh zhimin zhai renal cell carcinoma article wang hepatocellular carcinoma patients multiple myeloma patients mm cells immunomodulatory agents changing peripheral blood article log bortezomib-based therapy check access instant access significantly increased compared increased cd14 multiple myeloma treatment clinical cancer stage european economic area related subjects von der maase

Schema {šŸ—ŗļø}

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         headline:Tumor-induced CD14+HLA-DRāˆ’/low myeloid-derived suppressor cells correlate with tumor progression and outcome of therapy in multiple myeloma patients
         description:Myeloid-derived suppressor cells (MDSCs) are heterogeneous, immature, myeloid progenitor cells, which suppress immune responses against tumors. CD14+HLA-DRāˆ’/low monocytic MDSCs (M-MDSC) are increased in patients suffering from multiple myeloma (MM). However, the frequency and function of M-MDSCs with the relationship between the tumor development and outcome of therapy in MM remain unclear. In this study, we analyzed the changes in M-MDSCs in newly diagnosed, relapsed and remission MM patients. In addition, we also assessed the response of M-MDSCs in MM patients treated with a bortezomib-based therapy as well as the impact of bortezomib on the modulation of M-MDSCs in vitro. The levels of M-MDSCs in newly diagnosed and relapsed MM patients were significantly increased compared with those in remission MM patients and healthy donors. Moreover, the levels of M-MDSCs were shown to correlate with tumor progression. The decrease in M-MDSCs after proteasome inhibitory therapy suggested that M-MDSCs could be considered as an indicator for the efficacy of therapy. Finally, we found the plasma from newly diagnosed MM patients, and MM cells were able to induce the accumulation of M-MDSCs in vitro. These results indicated that M-MDSCs could be considered as a prognostic predictor and an important cell type contributing to immune suppressive microenvironment in MM patients. Treatments targeting for M-MDSCs may improve therapeutic outcomes for MM patients.
         datePublished:2014-12-30T00:00:00Z
         dateModified:2014-12-30T00:00:00Z
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            Tumor progressive
            Bortezomib
            Immunosuppression
            Oncology
            Immunology
            Cancer Research
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      headline:Tumor-induced CD14+HLA-DRāˆ’/low myeloid-derived suppressor cells correlate with tumor progression and outcome of therapy in multiple myeloma patients
      description:Myeloid-derived suppressor cells (MDSCs) are heterogeneous, immature, myeloid progenitor cells, which suppress immune responses against tumors. CD14+HLA-DRāˆ’/low monocytic MDSCs (M-MDSC) are increased in patients suffering from multiple myeloma (MM). However, the frequency and function of M-MDSCs with the relationship between the tumor development and outcome of therapy in MM remain unclear. In this study, we analyzed the changes in M-MDSCs in newly diagnosed, relapsed and remission MM patients. In addition, we also assessed the response of M-MDSCs in MM patients treated with a bortezomib-based therapy as well as the impact of bortezomib on the modulation of M-MDSCs in vitro. The levels of M-MDSCs in newly diagnosed and relapsed MM patients were significantly increased compared with those in remission MM patients and healthy donors. Moreover, the levels of M-MDSCs were shown to correlate with tumor progression. The decrease in M-MDSCs after proteasome inhibitory therapy suggested that M-MDSCs could be considered as an indicator for the efficacy of therapy. Finally, we found the plasma from newly diagnosed MM patients, and MM cells were able to induce the accumulation of M-MDSCs in vitro. These results indicated that M-MDSCs could be considered as a prognostic predictor and an important cell type contributing to immune suppressive microenvironment in MM patients. Treatments targeting for M-MDSCs may improve therapeutic outcomes for MM patients.
      datePublished:2014-12-30T00:00:00Z
      dateModified:2014-12-30T00:00:00Z
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         Myeloid-derived suppressor cells
         Multiple myeloma
         Tumor progressive
         Bortezomib
         Immunosuppression
         Oncology
         Immunology
         Cancer Research
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               name:Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
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            address:
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      name:Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
      name:Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
      name:Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
      name:Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
      name:College of Life Science, University of Science and Technology of China, Hefei, People’s Republic of China
      name:Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China
      name:Centre for Transplantation and Renal Research, Westmead Millennium Institute, The University of Sydney, Sydney, Australia
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External Links {šŸ”—}(214)

Analytics and Tracking {šŸ“Š}

  • Google Tag Manager

Libraries {šŸ“š}

  • Clipboard.js
  • Prism.js

CDN Services {šŸ“¦}

  • Crossref

4.67s.