We are analyzing https://link.springer.com/article/10.1007/s13277-016-4916-2.

Title:
The clinical and prognostic significance of CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients receiving radiotherapy | Tumor Biology
Description:
Myeloid-derived suppressor cells (MDSCs) are key player in mediating systemic immunosuppression, and their accumulation and expansion in the periphery and tumor have been iteratively observed in patients with various types of cancer. It has been reported that CD14+HLA-DR−/low MDSCs are increased in hepatocellular carcinoma (HCC) patients; however, the clinical significance of MDSC alteration in HCC patients after treatment is poorly studied. In this study, we examined the frequency of MDSCs in 92 HCC patients, 14 chronic liver disease patients without HCC, and 22 healthy controls by flow cytometric analysis. The associations between the clinical features and the frequency of MDSCs were analyzed. In particular, we further examined the prognostic impact of MDSCs on the overall survival of HCC patients receiving radiation therapy. The frequency of MDSCs in HCC patients was significantly increased and correlated with tumor stage, size, burden, and Child-Pugh classification but not with biochemical parameters of liver function. In HCC patients who received radiation therapy, the frequency of MDSCs after treatment significantly decreased and was inversely correlated with overall survival time. In multivariate analysis, only post-treatment MDSC ratio and Child-Pugh classification were correlated with the prognosis of HCC patients. Patients with a high frequency of MDSCs after radiotherapy should be closely followed, and the inhibition of MDSCs may improve the prognosis of patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, article, google, scholar, cells, cas, patients, suppressor, cancer, carcinoma, hepatocellular, myeloidderived, central, mdscs, hcc, tumor, myeloid, cdhladrlow, access, immunol, radiotherapy, liver, radiation, immune, privacy, cookies, content, publish, clinical, wang, frequency, therapy, oncology, beijing, analysis, data, search, prognostic, feng, increased, treatment, study, survival, open, nat, derived, res, hospital, function, information,

Topics {✒️}

immunosuppressive cd14+hla-drlow/− monocytes cd14+hla-dr−/low mdscs myeloid-derived suppressor cells peripheral myeloid-derived suppressor month download article/chapter impaired t-cell functionality intermediate/advanced hepatocellular carcinoma related subjects single-dose cyclophosphamide associates post-treatment mdsc ratio beijing chao-yang hospital inhibiting antitumor immunity tong-liao city hospital advanced hepatocellular carcinoma full article pdf pd-l1+mdscs hla-dr hepatocellular carcinoma patients ostrand-rosenberg myeloid cells privacy choices/manage cookies received radiation therapy multipeptide immune response article wang regulatory cells cancer cell hepatocellular carcinoma cancer vaccine ima901 stereotactic body radiotherapy nat rev cancer immune suppression mediated cancer immunol immunother european economic area mediating systemic immunosuppression child-pugh classification hepatic arterial infusion diaz-montero cm l-arginine metabolism th2 cytokine interleukin-13 excellent technical assistance capital medical university armed police forces rectal cancer patients treatment significantly decreased article log conditions privacy policy sci transl med clin cancer res hepatocellular cancer semin radiat oncol

Questions {❓}

Treatment of intermediate/advanced hepatocellular carcinoma in the clinic: how can outcomes be improved?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The clinical and prognostic significance of CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients receiving radiotherapy
         description:Myeloid-derived suppressor cells (MDSCs) are key player in mediating systemic immunosuppression, and their accumulation and expansion in the periphery and tumor have been iteratively observed in patients with various types of cancer. It has been reported that CD14+HLA-DR−/low MDSCs are increased in hepatocellular carcinoma (HCC) patients; however, the clinical significance of MDSC alteration in HCC patients after treatment is poorly studied. In this study, we examined the frequency of MDSCs in 92 HCC patients, 14 chronic liver disease patients without HCC, and 22 healthy controls by flow cytometric analysis. The associations between the clinical features and the frequency of MDSCs were analyzed. In particular, we further examined the prognostic impact of MDSCs on the overall survival of HCC patients receiving radiation therapy. The frequency of MDSCs in HCC patients was significantly increased and correlated with tumor stage, size, burden, and Child-Pugh classification but not with biochemical parameters of liver function. In HCC patients who received radiation therapy, the frequency of MDSCs after treatment significantly decreased and was inversely correlated with overall survival time. In multivariate analysis, only post-treatment MDSC ratio and Child-Pugh classification were correlated with the prognosis of HCC patients. Patients with a high frequency of MDSCs after radiotherapy should be closely followed, and the inhibition of MDSCs may improve the prognosis of patients.
         datePublished:2016-02-05T00:00:00Z
         dateModified:2016-02-05T00:00:00Z
         pageStart:10427
         pageEnd:10433
         sameAs:https://doi.org/10.1007/s13277-016-4916-2
         keywords:
            Myeloid-derived suppressor cells
            Hepatocellular carcinoma
            Radiation therapy
            Overall survival
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-016-4916-2/MediaObjects/13277_2016_4916_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-016-4916-2/MediaObjects/13277_2016_4916_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-016-4916-2/MediaObjects/13277_2016_4916_Fig3_HTML.gif
         isPartOf:
            name:Tumor Biology
            issn:
               1423-0380
               1010-4283
            volumeNumber:37
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Dong Wang
               affiliation:
                     name:Capital Medical University
                     address:
                        name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
                        type:PostalAddress
                     type:Organization
                     name:Tong-Liao City Hospital of Inner Mongolia
                     address:
                        name:Department of Oncology, Tong-Liao City Hospital of Inner Mongolia, Tong-Liao, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Guangyu An
               affiliation:
                     name:Capital Medical University
                     address:
                        name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shengzhi Xie
               affiliation:
                     name:General Hospital of Chinese People’s Armed Police Forces
                     address:
                        name:Department of Oncology, General Hospital of Chinese People’s Armed Police Forces, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yajuan Yao
               affiliation:
                     name:Tong-Liao City Hospital of Inner Mongolia
                     address:
                        name:Department of Oncology, Tong-Liao City Hospital of Inner Mongolia, Tong-Liao, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Guosheng Feng
               affiliation:
                     name:Capital Medical University
                     address:
                        name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The clinical and prognostic significance of CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients receiving radiotherapy
      description:Myeloid-derived suppressor cells (MDSCs) are key player in mediating systemic immunosuppression, and their accumulation and expansion in the periphery and tumor have been iteratively observed in patients with various types of cancer. It has been reported that CD14+HLA-DR−/low MDSCs are increased in hepatocellular carcinoma (HCC) patients; however, the clinical significance of MDSC alteration in HCC patients after treatment is poorly studied. In this study, we examined the frequency of MDSCs in 92 HCC patients, 14 chronic liver disease patients without HCC, and 22 healthy controls by flow cytometric analysis. The associations between the clinical features and the frequency of MDSCs were analyzed. In particular, we further examined the prognostic impact of MDSCs on the overall survival of HCC patients receiving radiation therapy. The frequency of MDSCs in HCC patients was significantly increased and correlated with tumor stage, size, burden, and Child-Pugh classification but not with biochemical parameters of liver function. In HCC patients who received radiation therapy, the frequency of MDSCs after treatment significantly decreased and was inversely correlated with overall survival time. In multivariate analysis, only post-treatment MDSC ratio and Child-Pugh classification were correlated with the prognosis of HCC patients. Patients with a high frequency of MDSCs after radiotherapy should be closely followed, and the inhibition of MDSCs may improve the prognosis of patients.
      datePublished:2016-02-05T00:00:00Z
      dateModified:2016-02-05T00:00:00Z
      pageStart:10427
      pageEnd:10433
      sameAs:https://doi.org/10.1007/s13277-016-4916-2
      keywords:
         Myeloid-derived suppressor cells
         Hepatocellular carcinoma
         Radiation therapy
         Overall survival
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-016-4916-2/MediaObjects/13277_2016_4916_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-016-4916-2/MediaObjects/13277_2016_4916_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs13277-016-4916-2/MediaObjects/13277_2016_4916_Fig3_HTML.gif
      isPartOf:
         name:Tumor Biology
         issn:
            1423-0380
            1010-4283
         volumeNumber:37
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Dong Wang
            affiliation:
                  name:Capital Medical University
                  address:
                     name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
                     type:PostalAddress
                  type:Organization
                  name:Tong-Liao City Hospital of Inner Mongolia
                  address:
                     name:Department of Oncology, Tong-Liao City Hospital of Inner Mongolia, Tong-Liao, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Guangyu An
            affiliation:
                  name:Capital Medical University
                  address:
                     name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shengzhi Xie
            affiliation:
                  name:General Hospital of Chinese People’s Armed Police Forces
                  address:
                     name:Department of Oncology, General Hospital of Chinese People’s Armed Police Forces, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yajuan Yao
            affiliation:
                  name:Tong-Liao City Hospital of Inner Mongolia
                  address:
                     name:Department of Oncology, Tong-Liao City Hospital of Inner Mongolia, Tong-Liao, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Guosheng Feng
            affiliation:
                  name:Capital Medical University
                  address:
                     name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Tumor Biology
      issn:
         1423-0380
         1010-4283
      volumeNumber:37
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Capital Medical University
      address:
         name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
         type:PostalAddress
      name:Tong-Liao City Hospital of Inner Mongolia
      address:
         name:Department of Oncology, Tong-Liao City Hospital of Inner Mongolia, Tong-Liao, China
         type:PostalAddress
      name:Capital Medical University
      address:
         name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
         type:PostalAddress
      name:General Hospital of Chinese People’s Armed Police Forces
      address:
         name:Department of Oncology, General Hospital of Chinese People’s Armed Police Forces, Beijing, China
         type:PostalAddress
      name:Tong-Liao City Hospital of Inner Mongolia
      address:
         name:Department of Oncology, Tong-Liao City Hospital of Inner Mongolia, Tong-Liao, China
         type:PostalAddress
      name:Capital Medical University
      address:
         name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Dong Wang
      affiliation:
            name:Capital Medical University
            address:
               name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
               type:PostalAddress
            type:Organization
            name:Tong-Liao City Hospital of Inner Mongolia
            address:
               name:Department of Oncology, Tong-Liao City Hospital of Inner Mongolia, Tong-Liao, China
               type:PostalAddress
            type:Organization
      name:Guangyu An
      affiliation:
            name:Capital Medical University
            address:
               name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
               type:PostalAddress
            type:Organization
      name:Shengzhi Xie
      affiliation:
            name:General Hospital of Chinese People’s Armed Police Forces
            address:
               name:Department of Oncology, General Hospital of Chinese People’s Armed Police Forces, Beijing, China
               type:PostalAddress
            type:Organization
      name:Yajuan Yao
      affiliation:
            name:Tong-Liao City Hospital of Inner Mongolia
            address:
               name:Department of Oncology, Tong-Liao City Hospital of Inner Mongolia, Tong-Liao, China
               type:PostalAddress
            type:Organization
      name:Guosheng Feng
      affiliation:
            name:Capital Medical University
            address:
               name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
      name:Department of Oncology, Tong-Liao City Hospital of Inner Mongolia, Tong-Liao, China
      name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
      name:Department of Oncology, General Hospital of Chinese People’s Armed Police Forces, Beijing, China
      name:Department of Oncology, Tong-Liao City Hospital of Inner Mongolia, Tong-Liao, China
      name:Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(150)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.1s.

LINK . SPRINGER . COM {}