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Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients | Cancer Immunology, Immunotherapy
Description:
Myeloid-derived suppressor cells are increased in the peripheral blood of advanced-stage cancer patients; however, no studies have shown a correlation of these immunosuppressive cells with clinical outcomes in melanoma patients. We characterized the frequency and suppressive function of multiple subsets of myeloid-derived suppressor cells in the peripheral blood of 34 patients with Stage IV melanoma, 20 patients with Stage I melanoma, and 15 healthy donors. The frequency of CD14+ MDSCs (Linβ CD11b+ HLA-DRβ CD14+ CD33+) and CD14β MDSCs (Linβ CD11b+ HLA-DRβ CD14β CD33+) was increased in the peripheral blood of Stage IV melanoma patients relative to healthy donors. The frequency of CD14+ and CD14β MDSCs correlated with each other and with the increased frequency of regulatory T cells, but not with classically defined monocytes. CD14β MDSCs isolated from the peripheral blood of Stage IV melanoma patients suppressed T cell activation more than those isolated from healthy donors, and the frequency of these cells correlated with disease progression and decreased overall survival. Our study provides the first evidence that the frequency of CD14β MDSCs negatively correlates with clinical outcomes in advanced-stage melanoma patients. These data indicate that suppressive MDSCs should be considered as targets for future immunotherapies.
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headline:Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients
description:Myeloid-derived suppressor cells are increased in the peripheral blood of advanced-stage cancer patients; however, no studies have shown a correlation of these immunosuppressive cells with clinical outcomes in melanoma patients. We characterized the frequency and suppressive function of multiple subsets of myeloid-derived suppressor cells in the peripheral blood of 34 patients with Stage IV melanoma, 20 patients with Stage I melanoma, and 15 healthy donors. The frequency of CD14+ MDSCs (Linβ CD11b+ HLA-DRβ CD14+ CD33+) and CD14β MDSCs (Linβ CD11b+ HLA-DRβ CD14β CD33+) was increased in the peripheral blood of Stage IV melanoma patients relative to healthy donors. The frequency of CD14+ and CD14β MDSCs correlated with each other and with the increased frequency of regulatory T cells, but not with classically defined monocytes. CD14β MDSCs isolated from the peripheral blood of Stage IV melanoma patients suppressed T cell activation more than those isolated from healthy donors, and the frequency of these cells correlated with disease progression and decreased overall survival. Our study provides the first evidence that the frequency of CD14β MDSCs negatively correlates with clinical outcomes in advanced-stage melanoma patients. These data indicate that suppressive MDSCs should be considered as targets for future immunotherapies.
datePublished:2013-09-27T00:00:00Z
dateModified:2013-09-27T00:00:00Z
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Myeloid-derived suppressor cells
Immunotherapy
Immunosuppression
Melanoma
Oncology
Immunology
Cancer Research
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headline:Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients
description:Myeloid-derived suppressor cells are increased in the peripheral blood of advanced-stage cancer patients; however, no studies have shown a correlation of these immunosuppressive cells with clinical outcomes in melanoma patients. We characterized the frequency and suppressive function of multiple subsets of myeloid-derived suppressor cells in the peripheral blood of 34 patients with Stage IV melanoma, 20 patients with Stage I melanoma, and 15 healthy donors. The frequency of CD14+ MDSCs (Linβ CD11b+ HLA-DRβ CD14+ CD33+) and CD14β MDSCs (Linβ CD11b+ HLA-DRβ CD14β CD33+) was increased in the peripheral blood of Stage IV melanoma patients relative to healthy donors. The frequency of CD14+ and CD14β MDSCs correlated with each other and with the increased frequency of regulatory T cells, but not with classically defined monocytes. CD14β MDSCs isolated from the peripheral blood of Stage IV melanoma patients suppressed T cell activation more than those isolated from healthy donors, and the frequency of these cells correlated with disease progression and decreased overall survival. Our study provides the first evidence that the frequency of CD14β MDSCs negatively correlates with clinical outcomes in advanced-stage melanoma patients. These data indicate that suppressive MDSCs should be considered as targets for future immunotherapies.
datePublished:2013-09-27T00:00:00Z
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Myeloid-derived suppressor cells
Immunotherapy
Immunosuppression
Melanoma
Oncology
Immunology
Cancer Research
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