We are analyzing https://link.springer.com/article/10.1007/s00262-013-1447-1.

Title:
Increase in CD14+HLA-DR−/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis | Cancer Immunology, Immunotherapy
Description:
Myeloid-derived suppressor cells (MDSCs) are known as key immune regulators in various human malignancies, and it is reported that CD14+HLA-DR−/low MDSCs are increased in hepatocellular carcinoma (HCC) patients. However, the host factors that regulate the frequency and the effect on the prognosis of HCC patients are still unclear. We investigated these issues and clarified the relationships between a feature of MDSCs and host factors in HCC patients. We examined the frequency of MDSCs in 123 HCC patients, 30 chronic liver disease patients without HCC, and 13 healthy controls by flow cytometric analysis. The relationships between the clinical features and the frequency of MDSCs were analyzed. In 33 patients who received curative radiofrequency ablation (RFA) therapy, we examined the impact of MDSCs on HCC recurrence. The frequency of MDSCs in HCC patients was significantly increased. It was correlated with tumor progression, but not with the degree of liver fibrosis and inflammation. In terms of serum cytokines, the concentrations of IL-10, IL-13, and vascular endothelial growth factor were significantly correlated with the frequency of MDSCs. In HCC patients who received curative RFA therapy, the frequency of MDSCs after treatment showed various changes and was inversely correlated with recurrence-free survival time. The frequency of MDSCs is correlated with tumor progression, and this frequency after RFA is inversely correlated with the prognosis of HCC patients. Patients with a high frequency of MDSCs after RFA should be closely followed and the inhibition of MDSCs may improve the prognosis of patients.
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Keywords {🔍}

article, pubmed, google, scholar, cells, cancer, cas, patients, carcinoma, hepatocellular, suppressor, myeloidderived, immunol, mdscs, hcc, tumor, frequency, cell, liver, factor, res, increased, radiofrequency, ablation, immune, factors, clinical, access, gastroenterology, privacy, cookies, content, cdhladrlow, prognosis, mizukoshi, rfa, correlated, growth, peripheral, myeloid, regulatory, clin, dendritic, publish, research, search, arihara, arai, yamashita, human,

Topics {✒️}

cd14+hla-dr−/low mdscs immunosuppressive cd14 + hla-drlow/- monocytes antigen-specific t-cell responses myeloid-derived suppressor cells myeloid suppressor cells month download article/chapter tatsuya yamashita & shuichi kaneko cd8 t-cell impairment related subjects recurrence-free survival time intermediate/advanced hepatocellular carcinoma article cancer immunology monocyte-derived macrophages hla-dr phase ii study cell expressed tumor-derived cytokines myeloid cells full article pdf cells hla radiofrequency thermal ablation percutaneous radiofrequency ablation privacy choices/manage cookies advanced hepatocellular carcinoma dendritic cells pulsed independent prognostic factor th2 cytokine interleukin-13 hepatocellular carcinoma patients defective antitumor function check access instant access hepatic arterial infusion metastatic tumor burden tumor-bearing mice cells correlate clinical cancer stage dendritic cell differentiation article arihara european economic area human malignancies de oliveira ac doxorubicin-cyclophosphamide chemotherapy facilitate tumor progression tumor microenvironment delays limits tumor progression conditions privacy policy radiofrequency ablation article log flow cytometric analysis electronic supplementary material

Questions {❓}

Lencioni R, Chen XP, Dagher L, Venook AP (2010) Treatment of intermediate/advanced hepatocellular carcinoma in the clinic: how can outcomes be improved?

Schema {🗺️}

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