We are analyzing https://link.springer.com/article/10.1007/s00262-013-1450-6.

Title:
Increased CD14+HLA-DR-/low myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients | Cancer Immunology, Immunotherapy
Description:
Accumulating evidence has demonstrated that myeloid-derived suppressor cells (MDSCs), a heterogeneous population of cells, play an important role in the subversion, inhibition, and downregulation of the immune response to cancer. However, the characteristics of these cells, particularly clinical relevance, in malignant tumors remain unclear due to a lack of specific markers. In this study, we characterized peripheral CD14+HLA-DR-/low cells, a new human MDSC subpopulation, in 89 patients with non-small cell lung cancer (NSCLC). As expected, both frequency and absolute number of CD14+HLA-DR-/low cells were significantly increased in the peripheral blood of NSCLC patients compared with that of the healthy controls and indicated an association with metastasis, response to chemotherapy, and progression-free survival. These cells showed decreased expression of CD16 and CD86 compared with HLA-DR+ monocytes. Unlike classical monocytes, these populations showed significantly decreased allostimulatory activity and showed the ability to inhibit autologous T cell proliferation and IFN-γ production in a cell-contact-dependent manner. Furthermore, we demonstrated that CD14+HLA-DR-/low cells expressed the NADPH oxidase component gp91phox and generated high level of reactive oxygen species (ROS). Moreover, inactivation of ROS reversed their immunosuppressive capacity on T cell response. These results prove, for the first time, the existence of ROS-producing CD14+HLA-DR-/low myeloid-derived suppressor cells in NSCLC patients, which mediate tumor immunosuppression and might thus represent a potential target for therapeutic intervention.
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Keywords {🔍}

cancer, article, cells, google, scholar, pubmed, cas, suppressor, myeloidderived, cell, patients, lung, immunol, cdhladrlow, nonsmall, monocytes, increased, response, huang, zhang, wang, clinical, immunosuppressive, lin, fan, human, nadph, myeloid, lee, immunother, dois, privacy, cookies, content, tumors, blood, activity, tumor, dendritic, clin, oncol, res, kuo, china, function, information, publish, research, search, correlate,

Topics {✒️}

cd14+hla-dr-/low cells expressed hla-dr-/low cells correlate cd14+hla-dr-/low cells ng-methyl-l-arginine acetate salt cd14+ hla-drlo/neg monocytes hla-dr-/low cells myeloid-derived suppressor cells ya-jun guo immunosuppressive cd14+ hla-dr month download article/chapter ke-xing fan hla-dr- cells cd14+ hla-dr dendritic cell vaccines myeloid suppressor cells cell-contact-dependent manner hla-dr+ monocytes boost tumor-specific cd4+ single-dose cyclophosphamide associates dendritic cell differentiation superoxide-generating nadph oxidase mediate tumor immunosuppression immature myeloid cells dendritic cells article cancer immunology hla-drlow/- monocytes national cancer institute full article pdf cancer vaccine ima901 squamous cell carcinoma progression-free survival proinflammatory myeloid subpopulation cd14-depleted arg1 lung cancer patients metastatic tumor burden immature immunosuppressive cd14 privacy choices/manage cookies myeloid cells reactive oxygen species independent prognostic factor clinical cancer stage related subjects improve patient outcome feng ph cell proliferation human mdsc subpopulation global cancer statistics unlike classical monocytes longer patient survival terminal cancer patients

Schema {🗺️}

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         headline:Increased CD14+HLA-DR-/low myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients
         description:Accumulating evidence has demonstrated that myeloid-derived suppressor cells (MDSCs), a heterogeneous population of cells, play an important role in the subversion, inhibition, and downregulation of the immune response to cancer. However, the characteristics of these cells, particularly clinical relevance, in malignant tumors remain unclear due to a lack of specific markers. In this study, we characterized peripheral CD14+HLA-DR-/low cells, a new human MDSC subpopulation, in 89 patients with non-small cell lung cancer (NSCLC). As expected, both frequency and absolute number of CD14+HLA-DR-/low cells were significantly increased in the peripheral blood of NSCLC patients compared with that of the healthy controls and indicated an association with metastasis, response to chemotherapy, and progression-free survival. These cells showed decreased expression of CD16 and CD86 compared with HLA-DR+ monocytes. Unlike classical monocytes, these populations showed significantly decreased allostimulatory activity and showed the ability to inhibit autologous T cell proliferation and IFN-γ production in a cell-contact-dependent manner. Furthermore, we demonstrated that CD14+HLA-DR-/low cells expressed the NADPH oxidase component gp91phox and generated high level of reactive oxygen species (ROS). Moreover, inactivation of ROS reversed their immunosuppressive capacity on T cell response. These results prove, for the first time, the existence of ROS-producing CD14+HLA-DR-/low myeloid-derived suppressor cells in NSCLC patients, which mediate tumor immunosuppression and might thus represent a potential target for therapeutic intervention.
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         dateModified:2013-06-13T00:00:00Z
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             HLA-DR expression
             Myeloid-derived suppressor cells
             Immunosuppression
             Tumor immunity
            Oncology
            Immunology
            Cancer Research
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      headline:Increased CD14+HLA-DR-/low myeloid-derived suppressor cells correlate with extrathoracic metastasis and poor response to chemotherapy in non-small cell lung cancer patients
      description:Accumulating evidence has demonstrated that myeloid-derived suppressor cells (MDSCs), a heterogeneous population of cells, play an important role in the subversion, inhibition, and downregulation of the immune response to cancer. However, the characteristics of these cells, particularly clinical relevance, in malignant tumors remain unclear due to a lack of specific markers. In this study, we characterized peripheral CD14+HLA-DR-/low cells, a new human MDSC subpopulation, in 89 patients with non-small cell lung cancer (NSCLC). As expected, both frequency and absolute number of CD14+HLA-DR-/low cells were significantly increased in the peripheral blood of NSCLC patients compared with that of the healthy controls and indicated an association with metastasis, response to chemotherapy, and progression-free survival. These cells showed decreased expression of CD16 and CD86 compared with HLA-DR+ monocytes. Unlike classical monocytes, these populations showed significantly decreased allostimulatory activity and showed the ability to inhibit autologous T cell proliferation and IFN-γ production in a cell-contact-dependent manner. Furthermore, we demonstrated that CD14+HLA-DR-/low cells expressed the NADPH oxidase component gp91phox and generated high level of reactive oxygen species (ROS). Moreover, inactivation of ROS reversed their immunosuppressive capacity on T cell response. These results prove, for the first time, the existence of ROS-producing CD14+HLA-DR-/low myeloid-derived suppressor cells in NSCLC patients, which mediate tumor immunosuppression and might thus represent a potential target for therapeutic intervention.
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      dateModified:2013-06-13T00:00:00Z
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          Immunosuppression
          Tumor immunity
         Oncology
         Immunology
         Cancer Research
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               type:PostalAddress
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      name:Ke-Xing Fan
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      name:International Joint Cancer Institute, The Second Military Medical University, Shanghai, People’s Republic of China
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