
PMC . NCBI . NLM . NIH . GOV {
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Title:
An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore - PMC
Description:
Stressful cellular events cause intracellular Ca2+ dysregulation, rapid loss of inner mitochondrial membrane potential [the permeability transition (PT)], metabolic dysfunction, and death. Rapid Ca2+-induced uncoupling is one of the most important ...
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27 years and 9 months (reg. 1997-10-02).
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Keywords {🔍}
csubunit, atp, fig, doi, synthase, channel, mitochondrial, pore, csa, conductance, pubmed, google, scholar, cells, purified, cell, death, ring, pmc, permeability, mptp, activity, transition, article, imm, data, cypd, protein, free, fluorescence, atpg, recordings, mitochondria, smvs, flash, uncoupling, membrane, reconstituted, binding, betasubunit, depletion, open, representative, addition, rapid, leak, kda, proteins, control, forms,
Topics {✒️}
atp5g1-encoded myc/flag-tagged c-subunits c-subunit single-channel conductance anti–pan-c-subunit antibody anti–c-subunit antibody represent high-conductance c-subunit channel adjacent c-subunit monomers individual c-subunit proteins atp synthase b-subunit purified c-subunit enhances voltage-dependent indicators jc-1 purified c-subunit channel c-subunit channel closure voltage-dependent anion channel purified c-subunit ring purified c-subunit protein c-subunit ring creates org/lookup/suppl/doi detects protein–protein interactions c-subunit channel results voltage-dependent channel sensitive single-channel activity induced octameric c-subunit forms pmc beta search c-subunit channel conductance flash-based fret approach overexpressed m4 c-subunit c-subunit leak conductance ion-conducting channels similar c-subunit channel activation protein-coupled receptor activation complete c-subunit purification long-sought molecular pore c-subunit isomers atp5g1 reconstituted c-subunit channels c-subunit ring structure c-subunit pore raised representative patch-clamp recordings reactive oxygen species bacterial na+-atp synthase m4 c-subunit rings anti–c-subunit antibodies f1-related enzymatic activity smv patch-clamp recordings atp concentration-dependence data high-affinity adp binding c-subunit attenuates glutamate-induced cell death ca2+-sensitive multiconductance channel cypd-mediated ca2+ binding mammalian c-subunit
Questions {❓}
- The mitochondrial permeability transition pore: A mystery solved?
- What makes you can also break you: Mitochondrial permeability transition pore formation by the c subunit of the F(1)F(0) ATP-synthase?
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