
PUBMED . NCBI . NLM . NIH . GOV {
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Title:
An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore - PubMed
Description:
Mitochondria maintain tight regulation of inner mitochondrial membrane (IMM) permeability to sustain ATP production. Stressful events cause cellular calcium (Ca(2+)) dysregulation followed by rapid loss of IMM potential known as permeability transition (PT), which produces osmotic shifts, metabolic …
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Keywords {🔍}
mitochondrial, csubunit, doi, pmc, permeability, pmid, transition, pore, free, article, atp, cell, death, pubmed, epub, synthase, metabolism, membrane, channel, nih, states, jonas, ring, imm, ion, fig, review, nsnsninds, hhsunited, abstract, similar, articles, mesh, jul, pnas, ffo, alavian, calcium, drug, effects, protein, main, ncbi, conflict, interest, cited, references, resources, proc, natl,
Topics {✒️}
ion-conducting channels similar metabolism proton electrochemical gradient v-atpases mitochondrial permeability transition united states government mitochondrial membrane ion channel c-ring conformation mitochondrial pt pore cellular calcium calcium hypothesis funding linkout age-related diseases permeability transition membrane depolarization breast cancer cells membrane current membrane fusion mitochondrial complex v mitochondrial disorders mitochondrial conductances cells mesh keyword cell death differ cell death disguised hhs c-subunit channel closure single-channel activity induced cell death main page content pore closure voltage-sensitive channel single-channel conductance pore permeability purified c-subunit enhances c-subunit attenuates ca uncoupling channel altering c-subunit expression healthy cell myofiber death c-subunit ring extracellular vesicle-mediated modulation articles references petronilli similar articles cited literature sources c-subunit sensitizes death f1fo atp synthase
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