
PMC . NCBI . NLM . NIH . GOV {
}
Title:
The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins - PMC
Description:
Early in programmed cell death (apoptosis), mitochondrial membrane permeability increases. This is at least in part due to opening of the permeability transition (PT) pore, a multiprotein complex built up at the contact site between the inner and ...
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Keywords {🔍}
doi, bcl, ptpc, liposomes, pubmed, google, scholar, mitochondrial, fig, caspases, cytochrome, release, apoptosis, dioc, pore, proteins, bclxl, caspase, mitochondria, permeability, membrane, pmc, cell, article, death, min, recombinant, atr, free, opening, transition, effect, reconstituted, functional, effects, presence, induced, hexokinase, ant, complex, kroemer, control, channel, protein, results, acid, inhibitors, isolated, activity, diamide,
Topics {✒️}
cmk [acetyl-tyr-val-ala-asp-chloromethylketone] cmk [acetyl-asp-glu-val-asp-chloromethylketone] acetyl-tyr-val-ala-asp-chloromethylketone acetyl-asp-glu-val-asp-chloromethylketone acetyl-tyr-val-ala-asp-aminomethylcoumarin n-benzyloxycarbonyl-val-ala-asp-fluoromethylketone acetyl-asp-glu-val-asp-aminomethylcoumarin 3% n-octyl-β-d-pyranoside n-methyl-4-val-csa [mod n-methyl-val-4-cyclosporin n-methyl-4-val cytochrome fas-based cell-mediated cytotoxicity fas/apo-1 cross-linking colas des francs-small ischemia/reperfusion-induced damage il-1β–converting enzyme pmc beta search acetyl-trp-glu pmc copyright notice putative channel-forming domain fas/apo-1–triggered apoptosis redox-sensitive sh groups voltage-dependent anion channel fluorogenic substrate ac-devd cell-free extracts dna damage-induced apoptosis cell-free system abolish caspase-induced dioc6 kcl-dependent ion gradient bax channel-forming activity potential-sensitive fluorochrome dioc6 bcl-xl regulate pt triton-soluble protein fraction bax-induced cell death asp-aminomethylcoumarin comparable sds-releasable dioc6 bcl-2–related proteins act anion exchange columns discussion functional equivalence fas/apo-1/cd95 mitochondrial adp/atp carrier recombinant human bcl-xl regulate membrane permeability signal transduction pathways nuclear dna degradation calcein-loaded ptpc liposomes hydrophobic transmembrane domain mammalian ced-4 homologue preferential enzyme binding adenine nucleotide translocator
Questions {❓}
- Protease activation during apoptosis: death by a thousand cuts?
- The Central Executioner of Apoptosis: Involvement of PTPC?
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