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We began analyzing https://www.nature.com/articles/380723a0, but it redirected us to https://www.nature.com/articles/380723a0. The analysis below is for the second page.

Title[redir]:
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis | Nature
Description:
BINDING of Fas ligand or an agonistic anti-Fas antibody induces apoptosis in Fas-bearing cells1. The interleukin-lβ-converting enzyme (ICE) is a cysteine protease2 that is involved in apoptosis induced by various stimuli, including Fas-mediated apoptosis3–8. Several ICE homologues have been identified, and these are subdivided into three groups (ICE-, CPP32- and Ich-1-like pro-teases)9–18. We show here that specific inhibitors of ICE- or CPP32-like proteases can inhibit Fas-mediated apoptosis. Tran-sient ICE-like activity was found in the cytosolic fraction of Fas-activated cells, whereas ICE-dependent, CPP32-like activity gradually accumulated in the cytosol. Cell lysates from mouse lymphoma supplemented with either recombinant ICE or CPP32 induced apoptosis of nuclei. The CPP32 inhibitor inhibited ICE-or CPP32-induced apoptosis in the cell-free system, whereas the ICE-inhibitor only inhibited ICE-induced apoptosis. Cell extracts from thymocytes from ICE-null mice induced apoptosis in the cell-free system when it was supplemented with CPP32. These results indicate that Fas sequentially activates ICE- and CPP32-like proteases, and that downstream CPP32, together with a component(s) in the cytoplasm, causes apoptosis of nuclei.

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article, google, scholar, cas, nature, cell, apoptosis, access, ads, biol, content, chem, cookies, nagata, ice, privacy, cpplike, proteases, enari, cells, induced, cpp, open, research, data, fasmediated, science, osaka, advertising, analysis, information, subscribe, icelike, talanian, wrong, shigekazu, institution, buy, cancer, fernandesalnemri, litwack, alnemri, embo, japan, permissions, optional, media, personal, including, parties,

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nature portfolio permissions reprints privacy policy 100 research drive tissue research advertising social media subscribe nature interleukin-lβ-converting enzyme including fas-mediated apoptosis3–8 nature 356 nature 375 nature 376 nature 371 nature 364 nature 380 nature apoptosis-related gene expression inhibit fas-mediated apoptosis inhibited ice-induced apoptosis springerlink instant access cancer stem cell fas-activated cells personal data data protection permissions mouse lymphoma supplemented fas-mediated apoptosis article enari privacy antitumoral effects induced fas-bearing cells1 cell-free system cpp32 induced apoptosis cpp32-induced apoptosis explore content subscription content european economic area institutional subscriptions read comparative proteomic analysis death receptor pathway accepting optional cookies fernandes-alnemri journals search log issue learn tran-sient ice manage preferences activity gradually accumulated access apoptosis induced

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