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Title:
Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts - PubMed
Description:
Reperfusion following a period of ischemia can salvage the myocardium only if the ischemic episode has not exceeded a certain time limit; beyond this point damage becomes irreversible. A key feature of the transition from reversible to irreversible injury is mitochondrial dysfunction which may invol …
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Keywords {🔍}
pmid, doi, reperfusion, cyclosporin, cell, cardiol, ischemia, mitochondria, heart, pmc, metabolism, mol, isolated, rat, hearts, transition, injury, mitochondrial, pore, effects, free, article, articles, mesh, jmcc, microm, permeability, epub, cyclosporine, myocardial, drug, main, content, ncbi, similar, cited, resources, damage, adenine, min, ventricular, pubmed, review, membranes, inhibitors, calcium, hhs, page, homepage, navigation,
Topics {✒️}
main page content similar articles cited myocardial ischemia adenine nucleotide depletion preventing calcium overload blood-perfused rat heart ischaemia/reperfusion injury literature sources cyclosporine ischemia/reperfusion-induced damage mesh keyword mitochondrial membranes ischemic heart disease post-ischemic contractile dysfunction irreversible injury protect isolated mitochondria myocardium resources intermittent ventricular fibrillation permeability transition pore mol cell cardiol mol cell biochem isolated rat hearts united states government atp/adp ratio pre-ischemic values pre-ischemic levels mitochondrial cyclophilin inhibits rev port cardiol reduces microvascular obstruction van de werf ginkgo biloba extract guinea-pig hearts basic res cardiol heart isolated mitochondria 15 min reperfusion permeability transition amp content cited 30 min ischemia 45 min ischemia cardiac mitochondria mitochondrial dysfunction protective effect reperfusion pore formation pubmed wordmark pubmed logo ischemic episode
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