We are analyzing https://link.springer.com/article/10.1186/s12943-020-01204-7.

Title:
The potential role of RNA N6-methyladenosine in Cancer progression | Molecular Cancer
Description:
N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, termed “writers”), removed by demethylases (FTO, ALKBH5, and ALKBH3, termed “erasers”), and recognized by m6A-binding proteins (YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, HNRNP, and eIF3, termed “readers”). Accumulating evidence suggests that m6A RNA methylation greatly impacts RNA metabolism and is involved in the pathogenesis of many kinds of diseases, including cancers. In this review, we focus on the physiological functions of m6A modification and its related regulators, as well as on the potential biological roles of these elements in human tumors.
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Keywords {🔍}

pubmed, cancer, article, google, scholar, cas, mettl, rna, cell, central, mrna, cells, expression, wang, modification, protein, zhang, methylation, ythdf, liu, found, translation, chen, factor, fto, role, promotes, addition, yang, progression, nmethyladenosine, alkbh, carcinoma, zhou, promote, proliferation, pathway, res, signaling, huang, domain, noncoding, tumor, mol, sun, rnas, important, growth, crc, hcc,

Topics {✒️}

n6-methyladenosine-dependent post-transcriptional modification photo-cross-linking-assisted m6a sequencing aff4/nf-κb/myc signaling network meiosis-specific coiled-coil domain alpha-ketoglutarate-dependent dioxygenase family augmented wnt/pi3k-akt signaling spi1-mettl14-myb/myc signaling axis α-ketoglutaric acid-dependent manner targeting fto/ma/myc/cebpa signaling mtorc1-mediated serine/glycine metabolism malat1–mir-1914-3p–yap axis malat1-mir-1914-3p-yap axis wnt/β-catenin signaling pathway mettl3-mediated n6-methyladenosine modification mrna-binding factor rbm15/spenito r-2hg-sensitive leukemia cells m6a-induced lncrna-rp11 promoted rna n6-methyladenosine-related genes cell-type-specific methylation patterns m6a-hur-dependent epigenetic silencing mir-1246/spred2/mapk signaling pathway full size image writer/reader virma/ythdf3 merip-m6a-seq analysis showed article download pdf zinc finger ccch-type zinc finger mym-type promotes cap-independent translation p21/p27-dependent pathway n-methyladenosine rna demethylase selective n-adenosine methylation multi-layer heterogeneous network n6-methyladenosine mettl3 promotes wnt/β-catenin pathway ma-dependent translation control tgf-β-induced emt rna editing events mettl3-mediated rna modification ctbp/lsd1/corest complex rna n6-methyladenosine methyltransferase rna n6-methyladenosine methyltransferase mettl3-mediated ma modification alkbh5-mediated ma demethylation kaplan-meier analysis showed producing s-adenosyl homocysteine n6-methyl-adenosine methyltranscriptome high-throughput m6a sequencing mrna n6-adenosine methyltransferase m6a-seq analysis performed n-methyladenosine-modified rna

Questions {❓}

How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients?

Schema {🗺️}

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         headline:The potential role of RNA N6-methyladenosine in Cancer progression
         description:N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, termed “writers”), removed by demethylases (FTO, ALKBH5, and ALKBH3, termed “erasers”), and recognized by m6A-binding proteins (YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, HNRNP, and eIF3, termed “readers”). Accumulating evidence suggests that m6A RNA methylation greatly impacts RNA metabolism and is involved in the pathogenesis of many kinds of diseases, including cancers. In this review, we focus on the physiological functions of m6A modification and its related regulators, as well as on the potential biological roles of these elements in human tumors.
         datePublished:2020-05-12T00:00:00Z
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            Oncology
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      headline:The potential role of RNA N6-methyladenosine in Cancer progression
      description:N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, termed “writers”), removed by demethylases (FTO, ALKBH5, and ALKBH3, termed “erasers”), and recognized by m6A-binding proteins (YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, HNRNP, and eIF3, termed “readers”). Accumulating evidence suggests that m6A RNA methylation greatly impacts RNA metabolism and is involved in the pathogenesis of many kinds of diseases, including cancers. In this review, we focus on the physiological functions of m6A modification and its related regulators, as well as on the potential biological roles of these elements in human tumors.
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         N6-methyladenosine (m6A)
         Molecular mechanisms
         Cancer progression
         Cancer Research
         Oncology
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      name:Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China
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