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Title[redir]:
ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma - PMC
Description:
Osteosarcoma (OS) is one of the most common malignant bone tumors. Plasmacytoma variant translocation 1 (PVT1) is a well-known oncogenic long noncoding RNA (lncRNA). However, to date, the regulatory mechanism of PVT1 upregulation in OS remains ...
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Keywords {๐}
pvt, alkbh, cells, expression, doi, rna, cell, fig, ythdf, cancer, patients, pubmed, google, scholar, assay, pmc, modification, qrtpcr, tumor, upregulation, tissues, overexpression, article, wang, knockdown, alkbhmediated, luciferase, free, proliferation, lncrna, mettl, data, long, noncoding, results, growth, stability, progression, normal, uos, measured, reporter, analysis, rip, activity, promotes, osteosarcoma, protein, test, methylation,
Topics {โ๏ธ}
activating c-met/pi3k/akt pathway methylated rna immune-precipitation competing endogenous rna long noncoding rnas n6-methyladenosine-dependent regulation long noncoding rna endogenous alkbh5 expression lncrnas-mediated m6a methylation regulating mir-497/hk2 axis supplementary information 12935_2020_1105_moesm1_esm pmc beta search regulate pre-mrna processing alkbh5-mediated m6a demethylation sponge mir-590-3p/mir-1275 mutant pvt1-fused reporter plasmacytoma pvt1 expression authors read authors declare runx2/lncrna-pvt1/mir-455 rnaโprotein complex protein coding capacity alkbh5-mediated m6a modification license information pmcid alkbh5-induced pvt1 upregulation competing interests hif-dependent alkbh5-mediated pvt1 upregulation methods qrt-pcr transcription factor runx2 publisher site pdf log-rank test showed alkbh5-mediated pvt1 stability supplementary materials included supplementary materials 12935_2020_1105_moesm1_esm alkbh5-overexpressed 143b cells primary antibodies overnight rna immunoprecipitation assay anti-ythdf2 rip assay promoted os growth alkbh5 suppresses nanog os remains unknown cell proliferation program facilitated tumor growth cell physiol biochem reader protein ythdf2 written informed consent cancer cell international cerna underwent surgical resection ฮฑ-amanitin
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