
NCBI . NLM . NIH . GOV {
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Title[redir]:
Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways - PMC
Description:
It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues indicated that caspase-1 can ...
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Keywords {🔍}
caspase, genes, doi, sirt, expression, ilβ, regulated, pubmed, gene, google, scholar, analysis, tissues, pmc, fig, article, metaanalysis, free, datasets, tissue, gse, microarray, effects, cell, liver, regulatory, significantly, data, adipose, pathways, globally, cooperation, substrates, inflammasome, identified, mouse, protein, changed, pathway, fold, tissuespecific, including, results, venn, activation, shown, table, regulate, metabolism, regulates,
Topics {✒️}
nicotinamide adenine dinucleotide european bioinformatics institute ifn-β promote interferon-β pmc beta search caspase-1-dependent interleukin-1beta secretion interleukin-1 beta proinflammatory il-1beta-rich microparticles immunosuppressive/anti-inflammatory cytokines directly interferon-inducible proteins member high-fat-diet feeding interferon-induced protein 44 il-1β transgene/treatment induced mature pro-inflammatory il-1β nf-kb-mediated inflammatory pathways nicotinamide nucleotide transhydrogenase nad nod embl ebi icv pro-inflammatory cytokines il-1β tumor necrosis factor pro-interleukin-1β molecular patterns il-1β treatment-induced genes mitochondria-mediated apoptosis pathway tissue-specific expression patterns gene expression omnibus gene expression omnibus degrading anti-inflammatory sirtuin-1 nicotinate/nicotinamide metabolism il-1β-mediated signaling pathways na+/ca2+-exchange protein 1 phosphatase-mediated de-phosphorylation kinase-mediated protein phosphorylation hydroxy-delta-5-steroid dehydrogenase generating mature il-1β regulating antigen-specific cd8+ retinoic acid-inducible gene il-1β-related microarray datasets endothelial progenitor cells il-1β including meg3 il-1β including gas5 cytosolic multi-protein complexes gov/geo/info/geo2r serine-type endopeptidase activity pathway-based approach identifies caspase-1 activates il-1β 3 beta
Questions {❓}
- Caspase-1: is IL-1 just the tip of the ICEberg?
- Muscle phosphorylase kinase deficiency: a neutral metabolic variant or a disease?
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