We are analyzing https://link.springer.com/article/10.1007/s00018-016-2212-3.

Title:
Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors | Cellular and Molecular Life Sciences
Description:
Nod-like receptors (NLRs) have gained attention in recent years because of the ability of some family members to assemble into a multimeric protein complex known as the inflammasome. The role of NLRs and the inflammasome in regulating innate immunity against bacterial pathogens has been well studied. However, recent studies show that NLRs and inflammasomes also play a role during infections caused by protozoan parasites, which pose a significant global health burden. Herein, we review the diseases caused by the most common protozoan parasites in the world and discuss the roles of NLRs and inflammasomes in host immunity against these parasites.
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Keywords {🔍}

pubmed, google, scholar, article, cas, central, immunol, infection, mice, cells, immunity, cell, leishmania, infect, inflammasome, malaria, nlrp, entamoeba, histolytica, response, role, host, major, immun, trypanosoma, med, parasitol, immune, resistance, cruzi, toxoplasma, nat, leishmaniasis, activation, disease, interleukin, susceptibility, responses, innate, nature, exp, plos, gondii, receptors, kanneganti, murine, parasite, dis, doiiai, control,

Topics {✒️}

month download article/chapter caspase-1-dependent il-1r-independent gal-lectin-dependent contact activates traf6-nf-kappab signaling pathways thirumala-devi kanneganti leukocyte-derived il-1ra plasmodium falciparum-infected erythrocytes transcription factor nf-kappab noncanonical nf-kappab signaling leucine-rich repeat domains microbiota-modulated metabolites shape macrophage-amebae intercellular junction myd88-deficient mice infected complement-mediated serum cytotoxicity ifn-gamma-independent production t-lymphocyte-independent induction ifn-gamma-dependent elimination amebic anti-inflammatory peptide gov/parasites/leishmaniasis/epi il-1ra-deficient mice th2 biased response t-cell-deficient hosts beta 2-microglobulin-deficient mice early ifn-gamma production allen ic inducible nitric oxide vivo il-1beta expression full article pdf entamoeba histolytica/entamoeba dispar article gurung class ii-restricted lima ds jr protective immune response nlrc5 negatively regulates plasmodium yoelii sporozoites protective effector functions cd8+ t-cell responses entamoeba histolytica induced wei xq gram-negative bacterial peptidoglycan class ii transactivator protective ifn-gamma human macrophages infected innate immune response local immune response intracerebral immune response cd4 t-cell subsets altered immune responses privacy choices/manage cookies cell clones derived

Questions {❓}

Kedzierski L (2010) Leishmaniasis vaccine: where are we today?

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