We are analyzing https://link.springer.com/article/10.1186/s13045-014-0080-6.

Title:
Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction- a novel mechanism for maintaining vascular function | Journal of Hematology & Oncology
Description:
Endothelial dysfunction is a pathological status of the vascular system, which can be broadly defined as an imbalance between endothelium-dependent vasoconstriction and vasodilation. Endothelial dysfunction is a key event in the progression of many pathological processes including atherosclerosis, type II diabetes and hypertension. Previous reports have demonstrated that pro-inflammatory/immunoeffector cytokines significantly promote endothelial dysfunction while numerous novel anti-inflammatory/immunosuppressive cytokines have recently been identified such as interleukin (IL)-35. However, the effects of anti-inflammatory cytokines on endothelial dysfunction have received much less attention. In this analytical review, we focus on the recent progress attained in characterizing the direct and indirect effects of anti-inflammatory/immunosuppressive cytokines in the inhibition of endothelial dysfunction. Our analyses are not only limited to the importance of endothelial dysfunction in cardiovascular disease progression, but also expand into the molecular mechanisms and pathways underlying the inhibition of endothelial dysfunction by anti-inflammatory/immunosuppressive cytokines. Our review suggests that anti-inflammatory/immunosuppressive cytokines serve as novel therapeutic targets for inhibiting endothelial dysfunction, vascular inflammation and cardio- and cerebro-vascular diseases.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

pubmed, google, scholar, cas, endothelial, vascular, cells, dysfunction, central, cytokines, expression, enos, function, production, antiinflammatory, role, mice, tgfβ, interleukin, cytokine, pathway, physiol, activation, cell, inflammatory, human, res, effects, proinflammatory, channels, activity, yang, endotheliumdependent, inflammation, factor, nitric, receptor, ang, circ, cardiovascular, diseases, blood, addition, arteries, oxide, phosphorylation, wang, edhf, artery, endotheliumderived,

Topics {✒️}

transforming growth factor-beta immunosuppressive/anti-inflammatory cytokines directly anti-inflammatory/immunosuppressive cytokines serve transforming growth factor-β anti-inflammatory/immunosuppressive cytokine generated nuclear factor-kappab-dependent induction phosphoinoside 3-kinase-akt-dependent pathway mir-125a/b-5p anti-inflammatory/anti-atherogenic micrornas [169] tumor necrosis factor-α endothelium-derived hyperpolarizing factor nitric oxide-mediated modulation angiotensin ii-infused mice il-1beta-induced inflammatory response tnf-α-treated mouse models gm-csf-induced p47phox phosphorylation tnf-α-infused il-10-/- mice angiotensin-ii-treated mice endothelium-derived hyperpolarizing factors regulating endothelium-dependent vasorelaxation anti-inflammatory cytokines determines tgf-β/smad2 signaling cytokine anta-gonists include angiotensin-induced vascular injury c-terminal reductase domain nitric oxide synthase responsive anti-inflammatory cytokine anti-inflammatory/immunosuppressive cytokines including lymphocyte-generated lymphokines distinct receptor-derived signals nf-kappab-dependent induction classical anti-inflammatory cytokines categorizing anti-inflammatory cytokines alleviates aldosterone-induced impairment n-terminal oxygenase domain flow-mediated dilation test ang ii-induced development anti-inflammatory cytokine interleukin-10 counteract pro-inflammatory cytokines interleukin-10-induced gene expression anti-inflammatory cytokines protect cytochrome p-450-related edhf anti-inflammatory cytokine levels nitric oxide regulates endothelium-dependent relaxations nf-kb-responsive genes isoforms including tgf-β1 vehicle-treat control mice /pi3-kinase/akt pathway [51] phosphatidylinositide 3-kinase/akt pathway

Questions {❓}

Haddad JJ, Fahlman CS: Redox- and oxidant-mediated regulation of interleukin-10: an anti-inflammatory, antioxidant cytokine?
Moussion C, Ortega N, Girard JP: The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?
Stenvinkel P: Endothelial dysfunction and inflammation-is there a link?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction- a novel mechanism for maintaining vascular function
         description:Endothelial dysfunction is a pathological status of the vascular system, which can be broadly defined as an imbalance between endothelium-dependent vasoconstriction and vasodilation. Endothelial dysfunction is a key event in the progression of many pathological processes including atherosclerosis, type II diabetes and hypertension. Previous reports have demonstrated that pro-inflammatory/immunoeffector cytokines significantly promote endothelial dysfunction while numerous novel anti-inflammatory/immunosuppressive cytokines have recently been identified such as interleukin (IL)-35. However, the effects of anti-inflammatory cytokines on endothelial dysfunction have received much less attention. In this analytical review, we focus on the recent progress attained in characterizing the direct and indirect effects of anti-inflammatory/immunosuppressive cytokines in the inhibition of endothelial dysfunction. Our analyses are not only limited to the importance of endothelial dysfunction in cardiovascular disease progression, but also expand into the molecular mechanisms and pathways underlying the inhibition of endothelial dysfunction by anti-inflammatory/immunosuppressive cytokines. Our review suggests that anti-inflammatory/immunosuppressive cytokines serve as novel therapeutic targets for inhibiting endothelial dysfunction, vascular inflammation and cardio- and cerebro-vascular diseases.
         datePublished:2014-10-31T00:00:00Z
         dateModified:2014-10-31T00:00:00Z
         pageStart:1
         pageEnd:14
         license:https://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13045-014-0080-6
         keywords:
            Anti-inflammatory cytokines
            Endothelial dysfunction
            Metabolic cardiovascular diseases
            Oncology
            Hematology
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-014-0080-6/MediaObjects/13045_2014_Article_80_Fig1_HTML.jpg
         isPartOf:
            name:Journal of Hematology & Oncology
            issn:
               1756-8722
            volumeNumber:7
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Ying Shao
               affiliation:
                     name:Temple University School of Medicine
                     address:
                        name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhongjian Cheng
               affiliation:
                     name:Temple University School of Medicine
                     address:
                        name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xinyuan Li
               affiliation:
                     name:Temple University School of Medicine
                     address:
                        name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Valeria Chernaya
               affiliation:
                     name:Temple University School of Medicine
                     address:
                        name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hong Wang
               affiliation:
                     name:Temple University School of Medicine
                     address:
                        name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiao-feng Yang
               affiliation:
                     name:Temple University School of Medicine
                     address:
                        name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
                     name:Temple University School of Medicine
                     address:
                        name:Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction- a novel mechanism for maintaining vascular function
      description:Endothelial dysfunction is a pathological status of the vascular system, which can be broadly defined as an imbalance between endothelium-dependent vasoconstriction and vasodilation. Endothelial dysfunction is a key event in the progression of many pathological processes including atherosclerosis, type II diabetes and hypertension. Previous reports have demonstrated that pro-inflammatory/immunoeffector cytokines significantly promote endothelial dysfunction while numerous novel anti-inflammatory/immunosuppressive cytokines have recently been identified such as interleukin (IL)-35. However, the effects of anti-inflammatory cytokines on endothelial dysfunction have received much less attention. In this analytical review, we focus on the recent progress attained in characterizing the direct and indirect effects of anti-inflammatory/immunosuppressive cytokines in the inhibition of endothelial dysfunction. Our analyses are not only limited to the importance of endothelial dysfunction in cardiovascular disease progression, but also expand into the molecular mechanisms and pathways underlying the inhibition of endothelial dysfunction by anti-inflammatory/immunosuppressive cytokines. Our review suggests that anti-inflammatory/immunosuppressive cytokines serve as novel therapeutic targets for inhibiting endothelial dysfunction, vascular inflammation and cardio- and cerebro-vascular diseases.
      datePublished:2014-10-31T00:00:00Z
      dateModified:2014-10-31T00:00:00Z
      pageStart:1
      pageEnd:14
      license:https://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13045-014-0080-6
      keywords:
         Anti-inflammatory cytokines
         Endothelial dysfunction
         Metabolic cardiovascular diseases
         Oncology
         Hematology
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-014-0080-6/MediaObjects/13045_2014_Article_80_Fig1_HTML.jpg
      isPartOf:
         name:Journal of Hematology & Oncology
         issn:
            1756-8722
         volumeNumber:7
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ying Shao
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhongjian Cheng
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xinyuan Li
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Valeria Chernaya
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hong Wang
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiao-feng Yang
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Temple University School of Medicine
                  address:
                     name:Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Hematology & Oncology
      issn:
         1756-8722
      volumeNumber:7
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Temple University School of Medicine
      address:
         name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Temple University School of Medicine
      address:
         name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Temple University School of Medicine
      address:
         name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Temple University School of Medicine
      address:
         name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Temple University School of Medicine
      address:
         name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Temple University School of Medicine
      address:
         name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Temple University School of Medicine
      address:
         name:Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ying Shao
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Zhongjian Cheng
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Xinyuan Li
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Valeria Chernaya
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Hong Wang
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Xiao-feng Yang
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Temple University School of Medicine
            address:
               name:Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
      name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
      name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
      name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
      name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
      name:Department of Pharmacology, Center for Metabolic Disease Research and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, USA
      name:Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, USA

External Links {🔗}(464)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref
Pbgrd

6.57s.

LINK . SPRINGER . COM {}