We are analyzing https://link.springer.com/article/10.1186/s13045-015-0130-8.

Title:
Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy | Journal of Hematology & Oncology
Description:
As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between endothelial progenitor cells (EPCs) and ischemic stroke have become a new hot spot and have reported that EPCs may protect the brain against ischemic injury, promote neurovascular repair, and improve long-term neurobehavioral outcomes. More importantly, they introduce a new perspective for prognosis assessment and therapy of ischemic stroke. However, EPCs’ origin, function, influence factors, injury repair mechanisms, and cell-based therapy strategies remain controversial. Particularly, research conducted to date has less clinical studies than pre-clinical experiments on animals. In this review, we summarized and analyzed the current understanding of basic characteristics, influence factors, functions, therapeutic strategies, and disadvantages of EPCs as well as the regulation of inflammatory factors involved in the function and survival of EPCs after ischemic stroke. Identifying potential therapeutic effects of EPCs in ischemic stroke will be a challenging but an incredibly important breakthrough in neurology, which may bring promise for patients with ischemic stroke.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

epcs, cells, pubmed, endothelial, ischemic, stroke, google, scholar, progenitor, cas, cell, blood, factors, epc, factor, circulating, homing, cerebral, ecs, receptor, central, stem, vascular, repair, function, bone, role, levels, protein, therapy, patients, promote, inflammatory, growth, expression, injury, increase, migration, mobilization, res, wang, angiogenesis, studies, vessels, signaling, zhang, therapeutic, survival, tissue, differentiation,

Topics {✒️}

p-selectin-p-selectin glycoprotein ligand-1 stromal-derived factor-1[alpha] correlates g-csf/stem cell factor granulocyte-monocyte-colony-stimulating factor human cd34 + ac133 + vegfr-2+ cells bone marrow-derived cells b-type natriuretic peptide ya-feng li myeloperoxidase-immunoreactive cell counts granulocyte-colony-stimulating factor granulocyte colony-stimulating factor vascular endothelial cell-cadherin bone marrow-derived epcs high-sensitivity c-reactive protein neural stem cells cerebral ischemia-reperfusion rats colony-outgrowth endothelial cells primitive hematopoietic progenitors high-density lipoprotein receptor endothelial colony-forming cells angiogenic gene profile angiotensin-converting enzyme inhibitor cerebral ischemia-reperfusion rat flk1/cd34-double-positive epcs peroxisome proliferator-activated receptor induced hind-limb ischemia basic characteristics brain-derived neurotrophic factor cell-permeable camp analog alpha-smooth muscle actin cd26/dipeptidyl peptidase iv focal cerebral ischemia tnf-alpha-induced protein 2 camp-dependent protein kinase stem cell factor cell-based angiogenic therapy angiogenic-related gene expressions total dpp-iv activity small-dense ldl cholesterol alde-low epcs naturally db/db diabetic mouse neural growth factor xiao-feng yang endothelial progenitors sdf-1alpha/rac pathway enhance dpp-iv activity tie2-lacz-positive cells cd34/kdr-positive cells stromal-derived factor endothelial progenitor cells

Schema {🗺️}

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         headline:Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy
         description:As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between endothelial progenitor cells (EPCs) and ischemic stroke have become a new hot spot and have reported that EPCs may protect the brain against ischemic injury, promote neurovascular repair, and improve long-term neurobehavioral outcomes. More importantly, they introduce a new perspective for prognosis assessment and therapy of ischemic stroke. However, EPCs’ origin, function, influence factors, injury repair mechanisms, and cell-based therapy strategies remain controversial. Particularly, research conducted to date has less clinical studies than pre-clinical experiments on animals. In this review, we summarized and analyzed the current understanding of basic characteristics, influence factors, functions, therapeutic strategies, and disadvantages of EPCs as well as the regulation of inflammatory factors involved in the function and survival of EPCs after ischemic stroke. Identifying potential therapeutic effects of EPCs in ischemic stroke will be a challenging but an incredibly important breakthrough in neurology, which may bring promise for patients with ischemic stroke.
         datePublished:2015-04-11T00:00:00Z
         dateModified:2015-04-11T00:00:00Z
         pageStart:1
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         license:https://creativecommons.org/publicdomain/zero/1.0/
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         keywords:
            Ischemic stroke
            Endothelial progenitor cells
            Basic characteristics
            Influence factors
            Function
            Therapy
            Inflammatory factors
            Review
            Oncology
            Hematology
            Cancer Research
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ScholarlyArticle:
      headline:Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy
      description:As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between endothelial progenitor cells (EPCs) and ischemic stroke have become a new hot spot and have reported that EPCs may protect the brain against ischemic injury, promote neurovascular repair, and improve long-term neurobehavioral outcomes. More importantly, they introduce a new perspective for prognosis assessment and therapy of ischemic stroke. However, EPCs’ origin, function, influence factors, injury repair mechanisms, and cell-based therapy strategies remain controversial. Particularly, research conducted to date has less clinical studies than pre-clinical experiments on animals. In this review, we summarized and analyzed the current understanding of basic characteristics, influence factors, functions, therapeutic strategies, and disadvantages of EPCs as well as the regulation of inflammatory factors involved in the function and survival of EPCs after ischemic stroke. Identifying potential therapeutic effects of EPCs in ischemic stroke will be a challenging but an incredibly important breakthrough in neurology, which may bring promise for patients with ischemic stroke.
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      dateModified:2015-04-11T00:00:00Z
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      keywords:
         Ischemic stroke
         Endothelial progenitor cells
         Basic characteristics
         Influence factors
         Function
         Therapy
         Inflammatory factors
         Review
         Oncology
         Hematology
         Cancer Research
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               type:PostalAddress
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               type:PostalAddress
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      name:Hong Wang
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      name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
      name:Department of Nephrology and Hemodialysis Center, The Second Hospital, Shanxi Medical University, Taiyuan, China
      name:The First Clinical Medical College, Shanxi Medical University, Taiyuan, China
      name:Department of Neurosurgery, The First Hospital, Shanxi Medical University, Taiyuan, China
      name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
      name:Department of Biology, College of Science and Technology, Temple University, Philadelphia, USA
      name:Department of Biology, College of Science and Technology, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA

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