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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries

We are analyzing https://link.springer.com/article/10.1186/s13045-015-0130-8.

Title:
Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy | Journal of Hematology & Oncology
Description:
As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between endothelial progenitor cells (EPCs) and ischemic stroke have become a new hot spot and have reported that EPCs may protect the brain against ischemic injury, promote neurovascular repair, and improve long-term neurobehavioral outcomes. More importantly, they introduce a new perspective for prognosis assessment and therapy of ischemic stroke. However, EPCs’ origin, function, influence factors, injury repair mechanisms, and cell-based therapy strategies remain controversial. Particularly, research conducted to date has less clinical studies than pre-clinical experiments on animals. In this review, we summarized and analyzed the current understanding of basic characteristics, influence factors, functions, therapeutic strategies, and disadvantages of EPCs as well as the regulation of inflammatory factors involved in the function and survival of EPCs after ischemic stroke. Identifying potential therapeutic effects of EPCs in ischemic stroke will be a challenging but an incredibly important breakthrough in neurology, which may bring promise for patients with ischemic stroke.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

epcs, cells, pubmed, endothelial, ischemic, stroke, google, scholar, progenitor, cas, cell, blood, factors, epc, factor, circulating, homing, cerebral, ecs, receptor, central, stem, vascular, repair, function, bone, role, levels, protein, therapy, patients, promote, inflammatory, growth, expression, injury, increase, migration, mobilization, res, wang, angiogenesis, studies, vessels, signaling, zhang, therapeutic, survival, tissue, differentiation,

Topics {✒️}

p-selectin-p-selectin glycoprotein ligand-1 stromal-derived factor-1[alpha] correlates g-csf/stem cell factor granulocyte-monocyte-colony-stimulating factor human cd34 + ac133 + vegfr-2+ cells bone marrow-derived cells b-type natriuretic peptide ya-feng li myeloperoxidase-immunoreactive cell counts granulocyte-colony-stimulating factor granulocyte colony-stimulating factor vascular endothelial cell-cadherin bone marrow-derived epcs high-sensitivity c-reactive protein neural stem cells cerebral ischemia-reperfusion rats colony-outgrowth endothelial cells primitive hematopoietic progenitors high-density lipoprotein receptor endothelial colony-forming cells angiogenic gene profile angiotensin-converting enzyme inhibitor cerebral ischemia-reperfusion rat flk1/cd34-double-positive epcs peroxisome proliferator-activated receptor induced hind-limb ischemia basic characteristics brain-derived neurotrophic factor cell-permeable camp analog alpha-smooth muscle actin cd26/dipeptidyl peptidase iv focal cerebral ischemia tnf-alpha-induced protein 2 camp-dependent protein kinase stem cell factor cell-based angiogenic therapy angiogenic-related gene expressions total dpp-iv activity small-dense ldl cholesterol alde-low epcs naturally db/db diabetic mouse neural growth factor xiao-feng yang endothelial progenitors sdf-1alpha/rac pathway enhance dpp-iv activity tie2-lacz-positive cells cd34/kdr-positive cells stromal-derived factor endothelial progenitor cells

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy
         description:As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between endothelial progenitor cells (EPCs) and ischemic stroke have become a new hot spot and have reported that EPCs may protect the brain against ischemic injury, promote neurovascular repair, and improve long-term neurobehavioral outcomes. More importantly, they introduce a new perspective for prognosis assessment and therapy of ischemic stroke. However, EPCs’ origin, function, influence factors, injury repair mechanisms, and cell-based therapy strategies remain controversial. Particularly, research conducted to date has less clinical studies than pre-clinical experiments on animals. In this review, we summarized and analyzed the current understanding of basic characteristics, influence factors, functions, therapeutic strategies, and disadvantages of EPCs as well as the regulation of inflammatory factors involved in the function and survival of EPCs after ischemic stroke. Identifying potential therapeutic effects of EPCs in ischemic stroke will be a challenging but an incredibly important breakthrough in neurology, which may bring promise for patients with ischemic stroke.
         datePublished:2015-04-11T00:00:00Z
         dateModified:2015-04-11T00:00:00Z
         pageStart:1
         pageEnd:17
         license:https://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13045-015-0130-8
         keywords:
            Ischemic stroke
            Endothelial progenitor cells
            Basic characteristics
            Influence factors
            Function
            Therapy
            Inflammatory factors
            Review
            Oncology
            Hematology
            Cancer Research
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            issn:
               1756-8722
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                        name:Department of Neurosurgery, The First Hospital, Shanxi Medical University, Taiyuan, China
                        type:PostalAddress
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               affiliation:
                     name:Temple University School of Medicine
                     address:
                        name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
                        type:PostalAddress
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                        type:PostalAddress
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               name:Su-Xuan Liu
               affiliation:
                     name:Temple University School of Medicine
                     address:
                        name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
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               affiliation:
                     name:Temple University School of Medicine
                     address:
                        name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiao-Feng Yang
               affiliation:
                     name:Temple University School of Medicine
                     address:
                        name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
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ScholarlyArticle:
      headline:Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy
      description:As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between endothelial progenitor cells (EPCs) and ischemic stroke have become a new hot spot and have reported that EPCs may protect the brain against ischemic injury, promote neurovascular repair, and improve long-term neurobehavioral outcomes. More importantly, they introduce a new perspective for prognosis assessment and therapy of ischemic stroke. However, EPCs’ origin, function, influence factors, injury repair mechanisms, and cell-based therapy strategies remain controversial. Particularly, research conducted to date has less clinical studies than pre-clinical experiments on animals. In this review, we summarized and analyzed the current understanding of basic characteristics, influence factors, functions, therapeutic strategies, and disadvantages of EPCs as well as the regulation of inflammatory factors involved in the function and survival of EPCs after ischemic stroke. Identifying potential therapeutic effects of EPCs in ischemic stroke will be a challenging but an incredibly important breakthrough in neurology, which may bring promise for patients with ischemic stroke.
      datePublished:2015-04-11T00:00:00Z
      dateModified:2015-04-11T00:00:00Z
      pageStart:1
      pageEnd:17
      license:https://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13045-015-0130-8
      keywords:
         Ischemic stroke
         Endothelial progenitor cells
         Basic characteristics
         Influence factors
         Function
         Therapy
         Inflammatory factors
         Review
         Oncology
         Hematology
         Cancer Research
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         name:Journal of Hematology & Oncology
         issn:
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         volumeNumber:8
         type:
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            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ya-Feng Li
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
                  name:Shanxi Medical University
                  address:
                     name:Department of Nephrology and Hemodialysis Center, The Second Hospital, Shanxi Medical University, Taiyuan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Li-Na Ren
            affiliation:
                  name:Shanxi Medical University
                  address:
                     name:The First Clinical Medical College, Shanxi Medical University, Taiyuan, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Geng Guo
            affiliation:
                  name:Shanxi Medical University
                  address:
                     name:Department of Neurosurgery, The First Hospital, Shanxi Medical University, Taiyuan, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Lee Anne Cannella
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Valeria Chernaya
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                  address:
                     name:Department of Biology, College of Science and Technology, Temple University, Philadelphia, USA
                     type:PostalAddress
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            type:Person
            name:Sonia Samuel
            affiliation:
                  name:Temple University
                  address:
                     name:Department of Biology, College of Science and Technology, Temple University, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Su-Xuan Liu
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hong Wang
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiao-Feng Yang
            affiliation:
                  name:Temple University School of Medicine
                  address:
                     name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
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      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Hematology & Oncology
      issn:
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      volumeNumber:8
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Temple University School of Medicine
      address:
         name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Shanxi Medical University
      address:
         name:Department of Nephrology and Hemodialysis Center, The Second Hospital, Shanxi Medical University, Taiyuan, China
         type:PostalAddress
      name:Shanxi Medical University
      address:
         name:The First Clinical Medical College, Shanxi Medical University, Taiyuan, China
         type:PostalAddress
      name:Shanxi Medical University
      address:
         name:Department of Neurosurgery, The First Hospital, Shanxi Medical University, Taiyuan, China
         type:PostalAddress
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         name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Temple University
      address:
         name:Department of Biology, College of Science and Technology, Temple University, Philadelphia, USA
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      address:
         name:Department of Biology, College of Science and Technology, Temple University, Philadelphia, USA
         type:PostalAddress
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      address:
         name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Temple University School of Medicine
      address:
         name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
      name:Temple University School of Medicine
      address:
         name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ya-Feng Li
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Shanxi Medical University
            address:
               name:Department of Nephrology and Hemodialysis Center, The Second Hospital, Shanxi Medical University, Taiyuan, China
               type:PostalAddress
            type:Organization
      name:Li-Na Ren
      affiliation:
            name:Shanxi Medical University
            address:
               name:The First Clinical Medical College, Shanxi Medical University, Taiyuan, China
               type:PostalAddress
            type:Organization
      name:Geng Guo
      affiliation:
            name:Shanxi Medical University
            address:
               name:Department of Neurosurgery, The First Hospital, Shanxi Medical University, Taiyuan, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Lee Anne Cannella
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Valeria Chernaya
      affiliation:
            name:Temple University
            address:
               name:Department of Biology, College of Science and Technology, Temple University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Sonia Samuel
      affiliation:
            name:Temple University
            address:
               name:Department of Biology, College of Science and Technology, Temple University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Su-Xuan Liu
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Hong Wang
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Xiao-Feng Yang
      affiliation:
            name:Temple University School of Medicine
            address:
               name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
      name:Department of Nephrology and Hemodialysis Center, The Second Hospital, Shanxi Medical University, Taiyuan, China
      name:The First Clinical Medical College, Shanxi Medical University, Taiyuan, China
      name:Department of Neurosurgery, The First Hospital, Shanxi Medical University, Taiyuan, China
      name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
      name:Department of Biology, College of Science and Technology, Temple University, Philadelphia, USA
      name:Department of Biology, College of Science and Technology, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research, and Thrombosis Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA

External Links {🔗}(283)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Clipboard.js
  • Prism.js

6.11s.